| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Legend of the Guardians: The Owls of Ga'Hoole | $261,509 | - | 97 | - | $2,695 | $263,637 | 1 | Warner Bros. | true | false |
| 2 | 2 | Eat Pray Love | $157,670 | -18.5% | 55 | - | $2,866 | $786,982 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | No Return | $141,789 | - | 50 | - | $2,835 | $141,789 | 1 | Distribution Company | true | false |
| 4 | 1 | Gaturro | $138,826 | -31.1% | 59 | -10 | $2,352 | $1,461,149 | 4 | Distribution Company | false | false |
| 5 | - | The Kids Are All Right | $106,259 | - | 26 | - | $4,086 | $106,259 | 1 | Alfa Films | true | false |
| 6 | 3 | Wall Street: Money Never Sleeps | $102,944 | -40.1% | 54 | +5 | $1,906 | $329,634 | 2 | 20th Century Fox International | false | false |
| 7 | 4 | Avatar 2010 Special Edition | $102,889 | -31.5% | 50 | +5 | $2,057 | $252,750 | 2 | 20th Century Fox International | false | false |
| 8 | 5 | The Last Exorcism | $95,586 | -17% | 40 | +1 | $2,389 | $828,623 | 4 | N/A | false | false |
| 9 | 8 | I Love You Phillip Morris | $60,260 | -21.6% | 26 | - | $2,317 | $162,922 | 2 | N/A | false | false |
| 10 | 6 | Igualita a mí | $48,604 | -47.1% | 66 | -16 | $736 | $3,466,937 | 8 | Walt Disney Pictures | false | false |
| 11 | 7 | The Expendables | $46,671 | -41.3% | 61 | - | $765 | $1,227,999 | 5 | Distribution Company | false | false |
| 12 | 9 | Inception | $40,248 | -22.9% | 43 | +15 | $936 | $4,973,879 | 10 | Warner Bros. | false | false |
| 13 | 10 | Tinker Bell and the Great Fairy Rescue | $33,625 | -27.8% | 37 | -2 | $908 | $533,267 | 5 | Walt Disney Pictures | false | false |
| 14 | 11 | The Man Next Door | $30,226 | -32.2% | 23 | -8 | $1,314 | $415,056 | 5 | Primer Plano Film Group | false | false |
| 15 | 12 | Killers | $23,603 | -31.8% | 28 | -1 | $842 | $221,295 | 4 | N/A | false | false |
| 16 | 14 | The Descent: Part 2 | $17,703 | -45.6% | 26 | +2 | $680 | $62,165 | 2 | CDI Films | false | false |
| 17 | 15 | Cats & Dogs: The Revenge of Kitty Galore | $16,447 | -48.5% | 42 | +1 | $391 | $1,389,318 | 7 | Warner Bros. | false | false |
| 18 | 16 | Lula, the Son of Brazil | $14,944 | -45.3% | 19 | +1 | $786 | $52,426 | 2 | N/A | false | false |
| 19 | 17 | The Dancer and the Thief | $8,985 | -55.4% | 27 | -3 | $332 | $239,415 | 4 | Walt Disney Pictures | false | false |
| 20 | 18 | Mademoiselle Chambon | $8,494 | -50.8% | 10 | - | $849 | $126,984 | 4 | CDI Films | false | false |
| 21 | 20 | Solitary Man | $8,110 | -30.9% | 15 | +3 | $540 | $210,932 | 6 | Distribution Company | false | false |
| 22 | 13 | The Last Airbender | $8,008 | -76% | 34 | +3 | $235 | $2,738,997 | 8 | Paramount Pictures International | false | false |
| 23 | - | Tell No One 2010 Re-release | $6,708 | - | 4 | - | $1,677 | $6,708 | 1 | N/A | true | false |
| 24 | 19 | Going the Distance | $6,643 | -55.3% | 25 | +1 | $265 | $295,848 | 5 | Warner Bros. | false | false |
| 25 | 21 | El rati horror show | $4,449 | -60% | 12 | -13 | $370 | $72,733 | 3 | Distribution Company | false | false |
| 26 | 22 | Yuki and Nina | $4,313 | -57.4% | 6 | -1 | $718 | $18,541 | 2 | N/A | false | false |
| 27 | 24 | The Hedgehog | $2,550 | -47.9% | 6 | - | $425 | $76,407 | 5 | Impacto Cine | false | false |
| 28 | 23 | Salt | $1,839 | -69.1% | 5 | -14 | $367 | $560,068 | 6 | Sony Pictures Releasing | false | false |
| 29 | 25 | Despicable Me | $1,833 | -54.2% | 12 | +4 | $152 | $2,870,324 | 10 | Universal Pictures International (UPI) | false | false |
| 30 | 26 | The Boys Are Back | $1,497 | -58.3% | 4 | -2 | $374 | $40,985 | 6 | Alfa Films | false | false |
| 31 | 29 | Still Walking | $1,361 | -52.6% | 2 | - | $680 | $43,535 | 5 | IFA | false | false |
| 32 | 40 | Chloe | $791 | +89.7% | 9 | +5 | $87 | $159,138 | 8 | Alfa Films | false | false |
| 33 | 42 | Letters to Juliet | $713 | +129.3% | 4 | +3 | $178 | $398,034 | 17 | Alfa Films | false | false |
| 34 | 32 | Neither God, Nor Master or Husband | $633 | -60.3% | 5 | - | $126 | $2,829 | 2 | Primer Plano Film Group | false | false |
| 35 | 39 | Pájaros volando | $616 | +37.2% | 5 | +4 | $123 | $450,066 | 9 | Primer Plano Film Group | false | false |
| 36 | 27 | Predators | $613 | -81.7% | 15 | -1 | $40 | $527,525 | 8 | 20th Century Fox International | false | false |
| 37 | 34 | Vincere | $522 | -38.6% | 2 | -1 | $261 | $342,620 | 9 | CDI Films | false | false |
| 38 | 37 | The Sorcerer's Apprentice | $255 | -61.3% | 7 | +6 | $36 | $3,129,066 | 12 | Walt Disney Pictures | false | false |
| 39 | 35 | Toy Story 3 | $244 | -67% | 7 | +4 | $34 | $15,871,799 | 16 | Walt Disney Pictures | false | false |
| 40 | 30 | London River 2010 Re-release | $222 | -91.4% | 1 | -3 | $222 | $77,714 | 7 | Primer Plano Film Group | false | false |
| 41 | 28 | The Invisible Eye | $202 | -93.5% | 4 | -4 | $50 | $73,869 | 7 | Distribution Company | false | false |
| 42 | 31 | Shrek Forever After | $128 | -94.4% | 8 | +4 | $16 | $13,808,259 | 13 | Paramount Pictures International | false | false |
| 43 | 33 | My Days with Gloria | $117 | -87.8% | 1 | -2 | $117 | $8,224 | 3 | N/A | false | false |
