| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $187,276 | -18.8% | 63 | -10 | $2,972 | $934,546 | 3 | Sony Pictures Releasing | false | false |
| 2 | - | The Expendables | $97,629 | - | 33 | - | $2,958 | $97,629 | 1 | N/A | true | false |
| 3 | 2 | Inception | $81,628 | -21.8% | 47 | -1 | $1,736 | $2,321,140 | 8 | Warner Bros. | false | false |
| 4 | - | Wall Street: Money Never Sleeps | $80,829 | - | 23 | - | $3,514 | $83,056 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Grown Ups | $72,319 | -12.7% | 30 | - | $2,410 | $412,049 | 4 | Sony Pictures Releasing | false | false |
| 6 | 4 | The Last Airbender | $51,189 | -20.9% | 32 | -4 | $1,599 | $1,667,688 | 7 | United International Pictures | false | false |
| 7 | 5 | Nanny McPhee Returns | $42,715 | -20.3% | 29 | +2 | $1,472 | $177,894 | 3 | United International Pictures | false | false |
| 8 | 6 | Tinker Bell and the Great Fairy Rescue | $25,972 | -24.7% | 20 | -2 | $1,298 | $254,965 | 5 | Walt Disney Pictures | false | false |
| 9 | 7 | Despicable Me | $24,466 | -13.7% | 19 | - | $1,287 | $1,366,338 | 10 | United International Pictures | false | false |
| 10 | 8 | Going the Distance | $14,789 | -31.4% | 18 | -2 | $821 | $174,523 | 5 | Warner Bros. | false | false |
| 11 | 9 | The Ghost Writer | $11,507 | -30% | 7 | - | $1,643 | $168,348 | 6 | N/A | false | false |
| 12 | 12 | The Fourth Kind | $9,045 | -15.5% | 9 | -1 | $1,005 | $156,036 | 6 | Transeuropa | false | false |
| 13 | 10 | Cats & Dogs: The Revenge of Kitty Galore | $8,175 | -40.3% | 8 | -6 | $1,021 | $882,509 | 9 | Warner Bros. | false | false |
| 14 | 16 | Toy Story 3 | $7,202 | +124.8% | 9 | +2 | $800 | $8,755,357 | 16 | Walt Disney Pictures | false | false |
| 15 | 13 | Avatar 2010 Special Edition | $4,550 | -49.5% | 5 | - | $910 | $199,925 | 5 | 20th Century Fox International | false | false |
| 16 | 14 | Carriers | $4,234 | -37.9% | 7 | -1 | $604 | $73,602 | 5 | N/A | false | false |
