| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Step Up 3D | $65,785 | -16.4% | 8 | - | $8,223 | $158,078 | 2 | N/A | false | false |
| 2 | - | Wall Street: Money Never Sleeps | $31,608 | - | 4 | - | $7,902 | $31,608 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Inception | $27,200 | -19.1% | 5 | - | $5,440 | $788,374 | 12 | Warner Bros. | false | false |
| 4 | 3 | Despicable Me | $23,359 | -16.7% | 8 | - | $2,919 | $96,505 | 3 | United International Pictures | false | false |
| 5 | 4 | The Sorcerer's Apprentice | $14,107 | -24.6% | 6 | -2 | $2,351 | $184,570 | 5 | Walt Disney Pictures | false | false |
| 6 | - | Letters to Juliet | $11,475 | - | 6 | - | $1,912 | $11,475 | 1 | N/A | true | false |
| 7 | 5 | The Other Guys | $8,782 | -51.3% | 4 | -1 | $2,195 | $66,218 | 3 | Sony Pictures Releasing | false | false |
| 8 | 6 | Going the Distance | $7,813 | -48.9% | 4 | - | $1,953 | $26,150 | 2 | Warner Bros. | false | false |
| 9 | 7 | Splice 2010 Re-release | $6,193 | -20.8% | 8 | - | $774 | $15,915 | 2 | N/A | false | false |
| 10 | 9 | Knight and Day 2010 Re-release | $4,937 | -5.7% | 1 | - | $4,937 | $443,283 | 14 | 20th Century Fox International | false | false |
| 11 | 8 | Cats & Dogs: The Revenge of Kitty Galore | $3,218 | -44.8% | 3 | - | $1,072 | $59,633 | 4 | Warner Bros. | false | false |
| 12 | 10 | Grown Ups | $2,732 | -32.9% | 1 | - | $2,732 | $158,395 | 9 | Sony Pictures Releasing | false | false |
| 13 | 12 | Predators | $2,580 | -31.3% | 3 | -1 | $860 | $56,982 | 6 | 20th Century Fox International | false | false |
| 14 | 15 | The Losers | $331 | -65.2% | 2 | -2 | $165 | $28,824 | 5 | Warner Bros. | false | false |
| 15 | 16 | Shrek Forever After | $130 | -40.1% | 1 | - | $130 | $254,188 | 14 | United International Pictures | false | false |
| 16 | 14 | The Last Airbender | $66 | -94.8% | 1 | -1 | $66 | $194,288 | 11 | United International Pictures | false | false |
