| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $73,306 | - | 8 | - | $9,163 | $73,306 | 1 | Jaguar Film International Distribution | true | false |
| 2 | 1 | Despicable Me | $44,851 | -27.5% | 7 | -1 | $6,407 | $125,581 | 2 | United International Pictures | false | false |
| 3 | 2 | Step Up 3D | $38,239 | -36.9% | 7 | -1 | $5,462 | $450,736 | 4 | Jaguar Film International Distribution | false | false |
| 4 | - | Going the Distance | $16,906 | - | 6 | - | $2,817 | $16,906 | 1 | Warner Bros. | true | false |
| 5 | - | The American | $15,821 | - | 7 | - | $2,260 | $15,821 | 1 | Italian International Film | true | false |
| 6 | 3 | Wall Street: Money Never Sleeps | $15,029 | -47.4% | 7 | - | $2,147 | $53,949 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | Dinner for Schmucks | $13,993 | -29.7% | 5 | -2 | $2,798 | $91,100 | 3 | United International Pictures | false | false |
| 8 | 6 | The Other Guys | $13,194 | -10.9% | 6 | - | $2,199 | $81,458 | 3 | Sony Pictures Releasing | false | false |
| 9 | 7 | The Expendables | $8,995 | -38.7% | 5 | -1 | $1,799 | $168,600 | 4 | N/A | false | false |
| 10 | 4 | Piranha 3D | $7,080 | -69.1% | 4 | -3 | $1,770 | $194,002 | 4 | Italian International Film | false | false |
| 11 | 8 | You Again | $6,095 | -52.5% | 5 | - | $1,219 | $22,547 | 2 | Walt Disney Pictures | false | false |
| 12 | 10 | Grown Ups | $4,898 | -36.1% | 2 | -2 | $2,449 | $245,660 | 8 | Sony Pictures Releasing | false | false |
| 13 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $4,629 | -51.2% | 2 | -3 | $2,314 | $106,350 | 4 | Warner Bros. | false | false |
| 14 | - | Everyday Is a Holiday | $2,970 | - | 3 | - | $990 | $2,970 | 1 | N/A | true | false |
| 15 | 12 | Inception | $2,572 | -62.3% | 2 | -2 | $1,286 | $553,628 | 10 | Warner Bros. | false | false |
| 16 | 14 | Knight and Day 2010 Re-release | $1,591 | +12% | 2 | - | $795 | $264,593 | 14 | 20th Century Fox International | false | false |
| 17 | 15 | 12 Angry Lebanese: The Documentary | $1,106 | -22.2% | 1 | - | $1,106 | $21,378 | 5 | N/A | false | false |
| 18 | 13 | 4.3.2.1. | $814 | -52.8% | 1 | - | $814 | $17,147 | 4 | Prime Pictures | false | false |
| 19 | 16 | The Sorcerer's Apprentice | $738 | -35.7% | 2 | - | $369 | $189,198 | 12 | Walt Disney Pictures | false | false |
| 20 | 18 | Partir | $656 | -38.5% | 3 | - | $218 | $13,751 | 5 | Italian International Film | false | false |
| 21 | 22 | Lembi 8 Giga | $587 | +17.4% | 1 | - | $587 | $212,311 | 11 | N/A | false | false |
| 22 | 11 | Charlie St. Cloud | $574 | -91.7% | 1 | -6 | $574 | $69,246 | 4 | United International Pictures | false | false |
| 23 | 20 | Triage | $431 | -47.7% | 2 | -1 | $215 | $3,408 | 3 | N/A | false | false |
| 24 | 21 | The Fourth Kind | $263 | -59.5% | 1 | -1 | $263 | $29,857 | 7 | N/A | false | false |
| 25 | 17 | Salt | $148 | -86.2% | 1 | -1 | $148 | $493,141 | 11 | Sony Pictures Releasing | false | false |
| 26 | 24 | Leap Year | $67 | -75.5% | 1 | - | $67 | $36,375 | 8 | N/A | false | false |
