| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $13,886 | -28.6% | 8 | - | $1,735 | $40,226 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Going the Distance | $7,428 | - | 6 | - | $1,238 | $9,099 | 1 | Warner Bros. | true | false |
| 3 | 2 | Grown Ups | $4,767 | -31.6% | 7 | - | $681 | $50,341 | 4 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Woman with a Broken Nose | $4,314 | -36.4% | 6 | - | $719 | $85,370 | 5 | N/A | false | false |
| 5 | 4 | Inception | $3,817 | -13% | 6 | - | $636 | $160,019 | 11 | Warner Bros. | false | false |
| 6 | 5 | Despicable Me | $3,240 | -25.6% | 6 | - | $540 | $28,424 | 4 | United International Pictures | false | false |
| 7 | 7 | Machete | $3,037 | -14.3% | 3 | - | $1,012 | $19,009 | 3 | N/A | false | false |
| 8 | 6 | The Expendables | $2,532 | -30.4% | 5 | - | $506 | $118,111 | 6 | N/A | false | false |
| 9 | - | Step Up 3D | $2,489 | - | 2 | - | $1,244 | $2,489 | 1 | N/A | true | false |
| 10 | 10 | Killers | $1,692 | +9.6% | 3 | - | $564 | $81,817 | 13 | N/A | false | false |
| 11 | 9 | The Karate Kid | $1,625 | -14.2% | 7 | - | $232 | $29,648 | 5 | Sony Pictures Releasing | false | false |
| 12 | 8 | Charlie St. Cloud | $1,018 | -60.3% | 5 | - | $203 | $10,998 | 3 | United International Pictures | false | false |
| 13 | 11 | The Killer Inside Me | $726 | -39.4% | 1 | - | $726 | $5,810 | 3 | N/A | false | false |
| 14 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $580 | -20.4% | 9 | - | $64 | $32,789 | 9 | Warner Bros. | false | false |
| 15 | 12 | Letters to Juliet | $513 | -56.9% | 4 | - | $128 | $24,381 | 7 | N/A | false | false |
| 16 | 13 | Salt | $437 | -52% | 5 | -1 | $87 | $73,757 | 9 | Sony Pictures Releasing | false | false |
| 17 | 15 | The Last Airbender | $414 | -22.6% | 6 | - | $69 | $50,411 | 7 | United International Pictures | false | false |
| 18 | 17 | Predators | $304 | +60% | 7 | - | $43 | $31,123 | 8 | 20th Century Fox International | false | false |
| 19 | 20 | When You're Strange | $246 | +138.8% | 1 | - | $246 | $10,991 | 10 | N/A | false | false |
| 20 | 19 | The Twilight Saga: Eclipse | $72 | -45.5% | 5 | - | $14 | $101,431 | 14 | N/A | false | false |
