| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Legend of the Guardians: The Owls of Ga'Hoole | $314,886 | - | 74 | - | $4,255 | $331,324 | 1 | Warner Bros. | true | false |
| 2 | - | Salt | $96,451 | - | 39 | - | $2,473 | $96,451 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Resident Evil: Afterlife | $78,017 | -58.3% | 41 | -22 | $1,902 | $1,172,820 | 4 | Sony Pictures Releasing | false | false |
| 4 | 2 | The Expendables | $65,812 | -32.6% | 32 | -1 | $2,056 | $239,782 | 2 | N/A | false | false |
| 5 | 3 | Inception | $61,140 | -25.1% | 28 | -19 | $2,183 | $2,441,111 | 9 | Warner Bros. | false | false |
| 6 | 4 | Wall Street: Money Never Sleeps | $54,959 | -32% | 24 | +1 | $2,289 | $179,053 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | Grown Ups | $49,997 | -30.9% | 28 | -2 | $1,785 | $509,963 | 5 | Sony Pictures Releasing | false | false |
| 8 | - | Hachi: A Dog's Tale | $44,240 | - | 14 | - | $3,160 | $218,025 | 4 | N/A | false | false |
| 9 | - | It's Alive | $25,892 | - | 11 | - | $2,353 | $25,892 | 1 | N/A | true | false |
| 10 | 6 | The Last Airbender | $24,902 | -51.4% | 22 | -10 | $1,131 | $1,692,590 | 8 | United International Pictures | false | false |
| 11 | 8 | Tinker Bell and the Great Fairy Rescue | $14,215 | -45.3% | 18 | -2 | $789 | $278,522 | 6 | Walt Disney Pictures | false | false |
| 12 | 7 | Nanny McPhee Returns | $13,885 | -67.5% | 19 | -10 | $730 | $208,650 | 4 | United International Pictures | false | false |
| 13 | 9 | Despicable Me | $11,966 | -51.1% | 13 | -6 | $920 | $1,378,304 | 11 | United International Pictures | false | false |
| 14 | 10 | Going the Distance | $6,479 | -56.2% | 11 | -7 | $589 | $192,824 | 6 | Warner Bros. | false | false |
| 15 | 11 | The Ghost Writer | $5,145 | -55.3% | 2 | -5 | $2,572 | $178,215 | 7 | N/A | false | false |
| 16 | 12 | The Fourth Kind | $4,425 | -51.1% | 4 | -5 | $1,106 | $169,801 | 7 | Transeuropa | false | false |
| 17 | 16 | Carriers | $1,929 | -54.4% | 6 | -1 | $321 | $81,862 | 6 | N/A | false | false |
