| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Resident Evil: Afterlife | $471,580 | - | 98 | - | $4,812 | $471,580 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | The American | $101,337 | - | 35 | - | $2,895 | $101,337 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | Buried | $96,502 | -50.2% | 39 | -1 | $2,474 | $382,332 | 2 | N/A | false | false |
| 4 | 3 | Life as We Know It | $93,031 | -38.1% | 41 | -2 | $2,269 | $307,867 | 2 | Warner Bros. | false | false |
| 5 | 4 | Eat Pray Love | $86,373 | -32.1% | 53 | -2 | $1,629 | $1,083,745 | 5 | Sony Pictures Releasing | false | false |
| 6 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $66,677 | -71.3% | 60 | -11 | $1,111 | $794,683 | 3 | Warner Bros. | false | false |
| 7 | 5 | Gaturro | $61,627 | -50.4% | 55 | -4 | $1,120 | $1,773,235 | 6 | Distribution Company | false | false |
| 8 | 6 | No Return | $59,042 | -49.2% | 47 | -2 | $1,256 | $420,935 | 3 | Distribution Company | false | false |
| 9 | 9 | The Last Exorcism | $45,011 | -43.8% | 39 | -2 | $1,154 | $1,023,567 | 6 | N/A | false | false |
| 10 | 10 | Charlie St. Cloud | $43,621 | -41.2% | 35 | - | $1,246 | $149,072 | 2 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | The Kids Are All Right | $39,173 | -55.6% | 26 | -3 | $1,506 | $292,838 | 3 | Alfa Films | false | false |
| 12 | 11 | Wall Street: Money Never Sleeps | $34,862 | -49.2% | 45 | -12 | $774 | $485,848 | 4 | 20th Century Fox International | false | false |
| 13 | 12 | I Love You Phillip Morris | $29,838 | -37.5% | 24 | -3 | $1,243 | $279,356 | 4 | N/A | false | false |
| 14 | 16 | Che: A New Man | $19,949 | -20.6% | 17 | +1 | $1,173 | $59,139 | 2 | Distribution Company | false | false |
| 15 | 7 | Avatar 2010 Special Edition | $18,183 | -81% | 24 | -26 | $757 | $390,527 | 4 | 20th Century Fox International | false | false |
| 16 | 17 | The Man Next Door | $15,529 | -36.4% | 22 | -2 | $705 | $476,502 | 7 | Primer Plano Film Group | false | false |
| 17 | 13 | Inception | $13,655 | -52.3% | 15 | -10 | $910 | $5,033,630 | 12 | Warner Bros. | false | false |
| 18 | 15 | Tinker Bell and the Great Fairy Rescue | $13,261 | -48.7% | 40 | -1 | $331 | $605,955 | 7 | Walt Disney Pictures | false | false |
| 19 | - | Giant | $9,071 | - | 9 | - | $1,007 | $9,071 | 1 | Primer Plano Film Group | true | false |
| 20 | 14 | Igualita a mí | $8,274 | -69.8% | 32 | -25 | $258 | $3,534,698 | 10 | Walt Disney Pictures | false | false |
| 21 | 19 | Killers | $7,348 | -49.8% | 23 | -2 | $319 | $253,872 | 6 | N/A | false | false |
| 22 | 18 | The Expendables | $6,327 | -71.7% | 34 | -21 | $186 | $1,287,687 | 7 | Distribution Company | false | false |
| 23 | 20 | Everlasting Moments 2010 Re-release | $4,774 | -45.7% | 4 | - | $1,193 | $17,084 | 2 | Alfa Films | false | false |
| 24 | 23 | The Dancer and the Thief | $3,190 | -50.3% | 29 | -3 | $110 | $257,250 | 6 | Walt Disney Pictures | false | false |
| 25 | 21 | Cats & Dogs: The Revenge of Kitty Galore | $2,898 | -56.9% | 14 | -14 | $207 | $1,409,051 | 9 | Warner Bros. | false | false |
| 26 | 27 | Tell No One 2010 Re-release | $2,293 | -55% | 4 | - | $573 | $19,551 | 3 | N/A | false | false |
| 27 | 26 | Solitary Man | $2,276 | -62.4% | 20 | +5 | $113 | $225,351 | 8 | Distribution Company | false | false |
| 28 | 22 | The Descent: Part 2 | $2,125 | -67.5% | 21 | -18 | $101 | $80,456 | 4 | CDI Films | false | false |
| 29 | 25 | The Last Airbender | $1,640 | -73.2% | 10 | -8 | $164 | $2,754,543 | 10 | Paramount Pictures International | false | false |
| 30 | 30 | The Hedgehog | $1,433 | -37.2% | 5 | -2 | $286 | $85,341 | 7 | Impacto Cine | false | false |
| 31 | 24 | Going the Distance | $1,335 | -78.7% | 19 | +2 | $70 | $310,610 | 7 | Warner Bros. | false | false |
| 32 | 35 | Yuki and Nina | $1,332 | +50.2% | 5 | +1 | $266 | $23,861 | 4 | N/A | false | false |
| 33 | 28 | Mademoiselle Chambon | $1,324 | -64.7% | 5 | -3 | $264 | $137,726 | 6 | CDI Films | false | false |
| 34 | 29 | Lula, the Son of Brazil | $887 | -67% | 5 | -2 | $177 | $62,536 | 4 | N/A | false | false |
| 35 | 34 | Salt | $843 | -17.8% | 7 | +1 | $120 | $562,778 | 8 | Sony Pictures Releasing | false | false |
| 36 | 32 | The Invisible Eye | $559 | -58.3% | 4 | -1 | $139 | $75,834 | 9 | Distribution Company | false | false |
| 37 | 33 | Despicable Me | $327 | -75.1% | 4 | -6 | $81 | $2,871,964 | 12 | Universal Pictures International (UPI) | false | false |
| 38 | 38 | Still Walking | $318 | -28.4% | 1 | - | $318 | $44,726 | 7 | IFA | false | false |
| 39 | - | Padres de la plaza: 10 recorridos posibles | $195 | - | 2 | - | $97 | $195 | 1 | Primer Plano Film Group | true | false |
| 40 | 41 | Vincere | $172 | +19.4% | 1 | -1 | $172 | $343,189 | 11 | CDI Films | false | false |
| 41 | 36 | Predators | $45 | -94.8% | 6 | -2 | $7 | $553,936 | 10 | 20th Century Fox International | false | false |
