| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Eat Pray Love | $2,149,071 | -37.2% | 330 | +2 | $6,512 | $7,108,303 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | The Town | $2,020,510 | - | 260 | - | $7,771 | $2,022,082 | 1 | Warner Bros. | true | false |
| 3 | - | Resident Evil: Afterlife | $1,863,034 | - | 186 | - | $10,016 | $1,946,753 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | Despicable Me | $532,433 | -66.1% | 317 | -64 | $1,679 | $21,012,175 | 7 | Universal Pictures International (UPI) | false | false |
| 5 | - | Let Me In | $407,531 | - | 150 | - | $2,716 | $407,531 | 1 | Icon Film Distribution | true | false |
| 6 | 4 | Dinner for Schmucks | $397,438 | -44.5% | 196 | -14 | $2,027 | $2,895,647 | 3 | Paramount Pictures International | false | false |
| 7 | 3 | Legend of the Guardians: The Owls of Ga'Hoole | $371,948 | -60.5% | 280 | -70 | $1,328 | $4,051,835 | 3 | Roadshow Films | false | false |
| 8 | 5 | Wall Street: Money Never Sleeps | $363,016 | -47% | 162 | -92 | $2,240 | $5,619,948 | 4 | 20th Century Fox International | false | false |
| 9 | 12 | Tomorrow, When the War Began | $280,174 | -40.1% | 168 | -20 | $1,667 | $12,934,314 | 7 | Paramount Pictures International | false | false |
| 10 | 10 | Easy A | $263,967 | -47.2% | 118 | -29 | $2,237 | $5,414,186 | 5 | Sony Pictures Releasing | false | false |
| 11 | 11 | The Other Guys | $262,168 | -46.9% | 138 | -38 | $1,899 | $10,010,429 | 6 | Sony Pictures Releasing | false | false |
| 12 | 7 | Buried | $252,842 | -61.4% | 138 | -10 | $1,832 | $1,116,624 | 2 | Icon Film Distribution | false | false |
| 13 | 13 | The Girl Who Played with Fire | $242,799 | -26.7% | 99 | +7 | $2,452 | $2,213,735 | 4 | Rialto Distribution | false | false |
| 14 | 6 | The Last Airbender | $204,249 | -70.2% | 152 | -126 | $1,343 | $9,517,364 | 5 | Paramount Pictures International | false | false |
| 15 | 8 | Diary of a Wimpy Kid | $187,290 | -71.4% | 169 | -40 | $1,108 | $4,959,675 | 4 | 20th Century Fox International | false | false |
| 16 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $135,730 | -78.8% | 201 | -132 | $675 | $6,291,300 | 5 | Roadshow Films | false | false |
| 17 | 14 | The Sorcerer's Apprentice | $74,895 | -66% | 66 | -67 | $1,134 | $4,898,922 | 6 | Walt Disney Pictures | false | false |
| 18 | - | Chloe | $61,159 | - | 11 | - | $5,559 | $77,388 | 1 | Roadshow Films | true | false |
| 19 | 16 | Inception | $57,904 | -38% | 24 | -19 | $2,412 | $35,025,970 | 13 | Warner Bros. | false | false |
| 20 | 15 | Charlie St. Cloud | $49,114 | -74.7% | 58 | -99 | $846 | $2,135,908 | 4 | Universal Pictures International (UPI) | false | false |
| 21 | - | The City of Your Final Destination | $29,630 | - | 18 | - | $1,646 | $29,630 | 1 | Potential Films | true | false |
| 22 | - | Summer Coda | $7,797 | - | 17 | - | $458 | $7,797 | - | Jump Street Films | - | false |
