| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $341,037 | -27.7% | 97 | -1 | $3,515 | $953,852 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | The Town | $199,042 | - | 45 | - | $4,423 | $199,733 | 1 | Warner Bros. | true | false |
| 3 | - | The Social Network | $179,638 | - | 51 | - | $3,522 | $179,638 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | Buried | $86,629 | -10.2% | 41 | +2 | $2,112 | $502,158 | 3 | N/A | false | false |
| 5 | 4 | Life as We Know It | $81,255 | -12.7% | 43 | +2 | $1,889 | $418,363 | 3 | Warner Bros. | false | false |
| 6 | 5 | Eat Pray Love | $76,374 | -11.6% | 53 | - | $1,441 | $1,184,766 | 6 | Sony Pictures Releasing | false | false |
| 7 | 7 | Gaturro | $74,262 | +20.5% | 56 | +1 | $1,326 | $1,870,305 | 7 | Distribution Company | false | false |
| 8 | 2 | The American | $61,933 | -38.9% | 34 | -1 | $1,821 | $191,922 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Legend of the Guardians: The Owls of Ga'Hoole | $60,756 | -8.9% | 54 | -6 | $1,125 | $880,469 | 4 | Warner Bros. | false | false |
| 10 | - | The Spy Next Door 2010 Re-release | $40,870 | - | 22 | - | $1,857 | $40,870 | 1 | N/A | true | false |
| 11 | 8 | No Return | $38,268 | -35.2% | 53 | +6 | $722 | $479,095 | 4 | Distribution Company | false | false |
| 12 | 11 | The Kids Are All Right | $32,133 | -18% | 29 | +3 | $1,108 | $338,965 | 4 | Alfa Films | false | false |
| 13 | 9 | The Last Exorcism | $31,503 | -30% | 36 | -3 | $875 | $1,071,664 | 7 | N/A | false | false |
| 14 | 10 | Charlie St. Cloud | $30,528 | -30% | 34 | -1 | $897 | $191,493 | 3 | Universal Pictures International (UPI) | false | false |
| 15 | 13 | I Love You Phillip Morris | $22,259 | -25.4% | 25 | +1 | $890 | $311,663 | 5 | N/A | false | false |
| 16 | - | The First Day of the Rest of Your Life | $18,993 | - | 10 | - | $1,899 | $18,993 | 1 | Impacto Cine | true | false |
| 17 | 12 | Wall Street: Money Never Sleeps | $17,398 | -50.1% | 47 | +2 | $370 | $514,318 | 5 | 20th Century Fox International | false | false |
| 18 | 15 | Avatar 2010 Special Edition | $16,561 | -8.9% | 15 | -9 | $1,104 | $412,137 | 5 | 20th Century Fox International | false | false |
| 19 | 18 | Tinker Bell and the Great Fairy Rescue | $14,726 | +11% | 39 | -1 | $377 | $625,523 | 8 | Walt Disney Pictures | false | false |
| 20 | 14 | Che: A New Man | $13,093 | -34.4% | 13 | -4 | $1,007 | $81,110 | 3 | Distribution Company | false | false |
| 21 | - | Lengua materna | $13,058 | - | 17 | - | $768 | $13,058 | 1 | Distribution Company | true | false |
| 22 | 17 | Inception | $11,174 | -18.2% | 11 | -4 | $1,015 | $5,048,591 | 13 | Warner Bros. | false | false |
| 23 | 16 | The Man Next Door | $9,380 | -39.6% | 13 | -9 | $721 | $490,495 | 8 | Primer Plano Film Group | false | false |
| 24 | 23 | Everlasting Moments 2010 Re-release | $3,840 | -19.6% | 4 | - | $960 | $23,066 | 3 | Alfa Films | false | false |
| 25 | 25 | Cats & Dogs: The Revenge of Kitty Galore | $3,636 | +25.5% | 7 | -7 | $519 | $1,413,713 | 10 | Warner Bros. | false | false |
| 26 | 21 | Killers | $2,265 | -69.2% | 8 | -15 | $283 | $257,923 | 7 | N/A | false | false |
| 27 | 19 | Giant | $2,050 | -77.4% | 6 | -3 | $341 | $14,939 | 2 | Primer Plano Film Group | false | false |
| 28 | 31 | Going the Distance | $1,616 | +21% | 11 | -8 | $146 | $313,426 | 8 | Warner Bros. | false | false |
| 29 | 29 | The Last Airbender | $1,471 | -10.3% | 5 | -5 | $294 | $2,756,967 | 11 | Paramount Pictures International | false | false |
| 30 | 26 | Tell No One 2010 Re-release | $1,112 | -51.5% | 2 | -2 | $556 | $21,807 | 4 | N/A | false | false |
| 31 | 30 | The Hedgehog | $1,035 | -27.8% | 2 | -3 | $517 | $87,231 | 8 | Impacto Cine | false | false |
| 32 | 37 | Despicable Me | $995 | +204.3% | 3 | -1 | $331 | $2,873,262 | 13 | Universal Pictures International (UPI) | false | false |
| 33 | 27 | Solitary Man | $863 | -62.1% | 6 | -14 | $143 | $227,502 | 9 | Distribution Company | false | false |
| 34 | 24 | The Dancer and the Thief | $793 | -75.1% | 8 | -21 | $99 | $260,612 | 7 | Walt Disney Pictures | false | false |
| 35 | 20 | Igualita a mí | $581 | -93% | 7 | -25 | $83 | $3,539,000 | 11 | Walt Disney Pictures | false | false |
| 36 | 28 | The Descent: Part 2 | $575 | -72.9% | 12 | -9 | $47 | $82,031 | 5 | CDI Films | false | false |
| 37 | 22 | The Expendables | $517 | -91.8% | 10 | -24 | $51 | $1,290,333 | 8 | Distribution Company | false | false |
| 38 | 36 | The Invisible Eye | $146 | -73.9% | 1 | -3 | $146 | $76,158 | 10 | Distribution Company | false | false |
| 39 | 32 | Yuki and Nina | $143 | -89.3% | 1 | -4 | $143 | $24,321 | 5 | N/A | false | false |
| 40 | 39 | Padres de la plaza: 10 recorridos posibles | $97 | -50.3% | 1 | -1 | $97 | $325 | 2 | Primer Plano Film Group | false | false |
