| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $26,766 | -24.6% | 16 | - | $1,672 | $198,024 | 4 | Warner Bros. | false | false |
| 2 | - | Life as We Know It | $16,420 | - | 5 | - | $3,284 | $16,420 | 1 | Warner Bros. | true | false |
| 3 | 4 | Piranha 3D | $9,094 | -11.3% | 6 | +3 | $1,515 | $87,445 | 6 | - | false | false |
| 4 | - | The Other Guys | $8,954 | - | 4 | - | $2,238 | $8,954 | 1 | Sony Pictures Releasing | true | false |
| 5 | 2 | Vampires Suck | $8,679 | -36% | 5 | - | $1,735 | $49,188 | 3 | 20th Century Fox International | false | false |
| 6 | 3 | Resident Evil: Afterlife | $8,121 | -38.9% | 9 | - | $902 | $382,906 | 7 | Sony Pictures Releasing | false | false |
| 7 | 5 | Solomon Kane | $7,543 | -26.2% | 4 | -1 | $1,885 | $37,710 | 3 | - | false | false |
| 8 | 6 | The Town | $6,401 | -35.5% | 4 | - | $1,600 | $20,528 | 2 | Warner Bros. | false | false |
| 9 | 7 | The Twilight Saga: Eclipse | $4,673 | -48% | 7 | -3 | $667 | $154,024 | 5 | - | false | false |
| 10 | - | Paintball | $4,034 | - | 2 | - | $2,017 | $4,034 | 1 | N/A | true | false |
| 11 | 8 | Wall Street: Money Never Sleeps | $3,117 | -38.2% | 5 | +1 | $623 | $46,597 | 5 | 20th Century Fox International | false | false |
| 12 | 11 | Smother | $1,091 | -31.6% | 2 | +1 | $545 | $6,276 | 3 | - | false | false |
| 13 | - | Carancho | $1,054 | - | 2 | - | $527 | $1,054 | 1 | N/A | true | false |
| 14 | 10 | Cats & Dogs: The Revenge of Kitty Galore | $558 | -67.3% | 3 | -2 | $186 | $273,148 | 10 | Warner Bros. | false | false |
| 15 | 9 | Grown Ups | $347 | -84.8% | 1 | -2 | $347 | $151,699 | 11 | Sony Pictures Releasing | false | false |
