| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Welcome to the South | $3,889,528 | -29.6% | 514 | -42 | $7,567 | $29,206,669 | 4 | Medusa Distribuzione | false | false |
| 2 | 2 | Despicable Me | $3,606,443 | -26.4% | 540 | -4 | $6,678 | $9,803,420 | 2 | United International Pictures | false | false |
| 3 | - | Wall Street: Money Never Sleeps | $1,544,534 | - | 324 | - | $4,767 | $1,544,534 | 1 | 20th Century Fox International | true | false |
| 4 | - | Paranormal Activity 2 | $1,538,955 | - | 250 | - | $6,155 | $1,538,955 | 1 | United International Pictures | true | false |
| 5 | 3 | Step Up 3D | $1,027,077 | -53.2% | 209 | -63 | $4,914 | $8,571,186 | 3 | Eagle Pictures | false | false |
| 6 | - | Unlikely Revolutionaries | $787,361 | - | 265 | - | $2,971 | $787,361 | 1 | Warner Bros. | true | false |
| 7 | - | Fair Game | $603,172 | - | 199 | - | $3,031 | $603,172 | 1 | Eagle Pictures | true | false |
| 8 | 5 | The Extraordinary Adventures of Adèle Blanc-Sec | $543,907 | -50.6% | 220 | -40 | $2,472 | $1,917,894 | 2 | Medusa Distribuzione | false | false |
| 9 | 4 | Inception | $507,817 | -54.9% | 136 | -114 | $3,733 | $14,039,728 | 5 | Warner Bros. | false | false |
| 10 | 6 | Buried | $395,445 | -62% | 136 | -30 | $2,907 | $1,804,451 | 2 | N/A | false | false |
| 11 | 7 | The Town | $314,416 | -64.7% | 131 | -121 | $2,400 | $3,057,016 | 3 | Warner Bros. | false | false |
| 12 | - | Of Gods and Men | $188,682 | - | 53 | - | $3,560 | $191,481 | 1 | Lucky Red | true | false |
| 13 | 8 | Knight and Day 2010 Re-release | $131,758 | -82.9% | 85 | -218 | $1,550 | $2,816,693 | 3 | 20th Century Fox International | false | false |
| 14 | 9 | Gorbaciof | $129,988 | -64.7% | 105 | -28 | $1,237 | $626,098 | 2 | Lucky Red | false | false |
| 15 | 12 | The City of Your Final Destination | $105,682 | -44.9% | 42 | -16 | $2,516 | $623,532 | 3 | Teodora Film | false | false |
| 16 | 10 | A Second Childhood | $84,367 | -73.9% | 43 | -146 | $1,962 | $1,250,287 | 3 | 01 Distribution | false | false |
| 17 | - | Passione | $73,569 | - | 39 | - | $1,886 | $73,569 | 1 | 01 Distribution | true | false |
| 18 | 13 | La passione di Laura | $60,052 | -59.5% | - | - | - | $3,241,272 | 5 | 01 Distribution | false | false |
| 19 | 11 | The Last Airbender | $40,644 | -80% | 18 | -62 | $2,258 | $7,908,085 | 5 | United International Pictures | false | false |
| 20 | 14 | The Black Sheep | $32,068 | -66.1% | 17 | -26 | $1,886 | $698,415 | 4 | BIM Distribuzione | false | false |
| 21 | 15 | Uncle Boonmee Who Can Recall His Past Lives | $24,893 | -61.7% | 17 | - | $1,464 | $118,743 | 2 | BIM Distribuzione | false | false |
| 22 | - | Seraphine | $14,741 | - | 12 | - | $1,228 | $14,741 | 1 | One Movie | true | false |
| 23 | 17 | Eat Pray Love | $11,282 | -69.5% | 23 | -28 | $490 | $4,980,680 | 6 | Sony Pictures Releasing | false | false |
| 24 | 20 | The Solitude of Prime Numbers | $10,972 | -45.2% | 8 | -6 | $1,371 | $4,641,801 | 7 | Medusa Distribuzione | false | false |
| 25 | 25 | Toy Story 3 | $5,485 | -35.7% | 9 | -2 | $609 | $18,855,881 | 16 | Walt Disney Pictures | false | false |
| 26 | 21 | Somewhere | $5,087 | -68.4% | 3 | -4 | $1,695 | $2,783,084 | 8 | Medusa Distribuzione | false | false |
| 27 | - | Step Up 2: The Streets | $3,779 | - | 4 | - | $944 | $5,313,261 | 132 | Moviemax | false | false |
| 28 | - | Basilicata Coast to Coast | $2,754 | - | 1 | - | $2,754 | $4,627,730 | 29 | Eagle Pictures | false | false |
| 29 | 19 | Shrek Forever After | $2,440 | -89.6% | 8 | - | $305 | $23,451,561 | 9 | United International Pictures | false | false |
| 30 | 16 | Grown Ups | $2,110 | -95% | 5 | -8 | $422 | $1,034,575 | 4 | Sony Pictures Releasing | false | false |
| 31 | 23 | Vampires Suck | $2,067 | -77.8% | 2 | -10 | $1,033 | $6,000,711 | 6 | 20th Century Fox International | false | false |
| 32 | 22 | Cats & Dogs: The Revenge of Kitty Galore | $1,942 | -81.1% | 6 | -5 | $323 | $1,833,580 | 6 | Warner Bros. | false | false |
| 33 | - | Tutti giù per terra | $1,291 | - | 1 | - | $1,291 | $771,254 | 1 | N/A | true | false |
