| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $37,159 | - | 7 | - | $5,308 | $44,645 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Skinning | $18,616 | -45.2% | 6 | - | $3,102 | $149,393 | 3 | N/A | false | false |
| 3 | - | Magic Journey to Africa | $11,420 | - | 1 | - | $11,420 | $18,623 | 1 | N/A | true | false |
| 4 | 2 | The Other Guys | $6,332 | -48.9% | 7 | - | $904 | $22,493 | 2 | Sony Pictures Releasing | false | false |
| 5 | 3 | Legend of the Guardians: The Owls of Ga'Hoole | $4,556 | -42.6% | 8 | +1 | $569 | $15,961 | 2 | Warner Bros. | false | false |
| 6 | 4 | The Woman with a Broken Nose | $2,345 | -40.7% | 6 | - | $390 | $104,095 | 8 | N/A | false | false |
| 7 | 7 | Inception | $2,257 | -32.9% | 6 | - | $376 | $177,216 | 14 | Warner Bros. | false | false |
| 8 | 11 | Machete | $2,166 | +57.4% | 3 | - | $722 | $28,910 | 6 | N/A | false | false |
| 9 | 10 | Step Up 3D | $1,553 | -31.7% | 3 | - | $517 | $11,685 | 4 | N/A | false | false |
| 10 | 6 | Grown Ups | $1,440 | -57.9% | 6 | -1 | $240 | $63,072 | 7 | Sony Pictures Releasing | false | false |
| 11 | 5 | Going the Distance | $1,410 | -62% | 6 | - | $235 | $31,983 | 4 | Warner Bros. | false | false |
| 12 | 9 | Despicable Me | $1,076 | -53.7% | 6 | - | $179 | $38,350 | 7 | United International Pictures | false | false |
| 13 | 8 | Resident Evil: Afterlife | $925 | -63.1% | 3 | -3 | $308 | $55,477 | 5 | Sony Pictures Releasing | false | false |
| 14 | 12 | The Expendables | $819 | -25.1% | 5 | - | $163 | $124,911 | 9 | N/A | false | false |
| 15 | 15 | The Karate Kid | $708 | +16.1% | 7 | +1 | $101 | $33,290 | 8 | Sony Pictures Releasing | false | false |
| 16 | 13 | The Killer Inside Me | $350 | -61% | 1 | - | $350 | $9,468 | 6 | N/A | false | false |
| 17 | 14 | Letters to Juliet | $215 | -66.2% | 4 | - | $53 | $26,922 | 10 | N/A | false | false |
| 18 | 20 | Predators | $160 | +226.5% | 7 | - | $22 | $32,105 | 11 | 20th Century Fox International | false | false |
| 19 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $82 | -80.8% | 9 | - | $9 | $34,599 | 12 | Warner Bros. | false | false |
| 20 | 16 | The Last Airbender | $66 | -86.9% | 6 | - | $11 | $51,923 | 10 | United International Pictures | false | false |
| 21 | 19 | When You're Strange | $47 | -39.7% | 1 | - | $47 | $11,362 | 13 | N/A | false | false |
| 22 | 18 | Charlie St. Cloud | $37 | -64.1% | 5 | - | $7 | $12,132 | 6 | United International Pictures | false | false |
