| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Paranormal Activity 2 | $5,905,354 | - | 389 | - | $15,180 | $5,905,354 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Despicable Me | $4,061,379 | -30.7% | 549 | +27 | $7,397 | $11,898,398 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | - | RED | $2,607,758 | - | 402 | - | $6,486 | $2,607,758 | 1 | Entertainment One | true | false |
| 4 | 2 | The Social Network | $2,413,407 | -39.3% | 399 | +5 | $6,048 | $8,406,314 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | Legend of the Guardians: The Owls of Ga'Hoole | $1,156,757 | - | 472 | - | $2,450 | $1,156,757 | 1 | Warner Bros. | true | false |
| 6 | - | Alpha and Omega | $1,009,278 | - | 391 | - | $2,581 | $1,009,278 | 1 | Lionsgate Films | true | false |
| 7 | 3 | Vampires Suck | $831,573 | -52.3% | 358 | -3 | $2,322 | $3,176,121 | 2 | 20th Century Fox International | false | false |
| 8 | - | Easy A | $436,032 | - | 203 | - | $2,147 | $436,032 | 1 | Sony Pictures Releasing | true | false |
| 9 | 5 | Life as We Know It | $412,753 | -58.7% | 309 | -84 | $1,335 | $4,579,138 | 3 | Warner Bros. | false | false |
| 10 | 4 | Wall Street: Money Never Sleeps | $406,218 | -62.4% | 225 | -217 | $1,805 | $5,800,814 | 3 | 20th Century Fox International | false | false |
| 11 | - | Africa United | $278,940 | - | 227 | - | $1,228 | $278,940 | 1 | Warner Bros. | true | false |
| 12 | 7 | Made in Dagenham | $245,819 | -55.2% | 185 | -131 | $1,328 | $4,739,720 | 4 | Paramount Pictures International | false | false |
| 13 | 6 | The Town | $198,863 | -63.8% | 127 | -126 | $1,565 | $7,484,217 | 5 | Warner Bros. | false | false |
| 14 | - | Ramona and Beezus | $132,508 | - | 256 | - | $517 | $132,508 | 1 | 20th Century Fox International | true | false |
| 15 | 8 | The Other Guys | $118,037 | -77.8% | 143 | -173 | $825 | $12,605,131 | 6 | Sony Pictures Releasing | false | false |
