| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $73,477 | -27.2% | 16 | - | $4,592 | $208,037 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | Eat Pray Love | $26,457 | -22.9% | 7 | - | $3,779 | $163,091 | 3 | ACME | false | false |
| 3 | - | The Social Network | $19,960 | - | 7 | - | $2,851 | $28,822 | 1 | ACME | true | false |
| 4 | 3 | RED | $13,191 | -16.2% | 4 | - | $3,297 | $36,629 | 2 | ACME | false | false |
| 5 | 4 | The Town | $9,658 | -30.2% | 4 | - | $2,414 | $30,530 | 2 | - | false | false |
| 6 | - | Devil | $7,580 | - | 2 | - | $3,790 | $7,580 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 5 | Legend of the Guardians: The Owls of Ga'Hoole | $5,954 | -24.7% | 7 | -1 | $850 | $118,273 | 4 | - | false | false |
| 8 | 6 | Buried | $4,694 | -19.2% | 5 | - | $938 | $78,092 | 4 | Incognito Films | false | false |
| 9 | 9 | A Turtle's Tale: Sammy's Adventures | $3,236 | -19.4% | 4 | - | $809 | $92,034 | 6 | ACME | false | false |
| 10 | 8 | Step Up 3D | $3,095 | -29.7% | 3 | -2 | $1,031 | $303,290 | 9 | ACME | false | false |
| 11 | 11 | Inception | $2,307 | +3.8% | 4 | -2 | $576 | $356,251 | 14 | - | false | false |
| 12 | 10 | Stone | $1,854 | -41% | 4 | - | $463 | $20,143 | 3 | Incognito Films | false | false |
| 13 | 7 | The Other Guys | $1,844 | -67.1% | 3 | -3 | $614 | $63,134 | 4 | ACME | false | false |
| 14 | 12 | Hong Kong Confidential | $1,302 | -25.6% | 2 | -1 | $651 | $121,558 | 6 | MEED Films | false | false |
| 15 | 23 | The Girl with the Dragon Tattoo | $1,071 | +950% | 2 | +1 | $535 | $26,650 | 10 | Incognito Films | false | false |
| 16 | - | Avatar | $822 | - | 3 | - | $274 | $1,493,257 | 45 | 20th Century Fox International | false | false |
| 17 | 17 | Cats & Dogs: The Revenge of Kitty Galore | $662 | +30.3% | 2 | - | $331 | $226,783 | 12 | Warner Bros. | false | false |
| 18 | 13 | Chatroom | $650 | -52.4% | 1 | -3 | $650 | $7,196 | 3 | MEED Films | false | false |
| 19 | 16 | Of Love and Other Demons | $648 | -7% | 2 | - | $324 | $17,241 | 5 | Incognito Films | false | false |
| 20 | 19 | Soul Kitchen | $584 | +123.8% | 1 | - | $584 | $9,564 | 9 | - | false | false |
| 21 | 15 | Going the Distance | $395 | -55.9% | 1 | -3 | $395 | $68,408 | 7 | - | false | false |
| 22 | 24 | All That I Love | $221 | +250.8% | 1 | - | $221 | $2,326 | 5 | - | false | false |
| 23 | 21 | The Sorcerer's Apprentice | $150 | -1.3% | 1 | - | $150 | $94,220 | 11 | Universal Pictures International (UPI) | false | false |
| 24 | 18 | Toy Story 3 | $85 | -79.1% | 1 | -2 | $85 | $224,106 | 16 | Universal Pictures International (UPI) | false | false |
| 25 | 22 | Vampires Suck | $79 | -42.3% | 1 | - | $79 | $70,537 | 10 | Universal Pictures International (UPI) | false | false |
| 26 | - | Prince of Persia: The Sands of Time | $65 | - | 1 | - | $65 | $183,590 | 22 | Universal Pictures International (UPI) | false | false |
| 27 | 20 | Marmaduke | $43 | -74.4% | 2 | -1 | $21 | $28,727 | 9 | Universal Pictures International (UPI) | false | false |
| 28 | 27 | Robin Hood | $15 | +87.5% | 1 | - | $15 | $209,489 | 24 | Universal Pictures International (UPI) | false | false |
