| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Paranormal Activity 2 | $197,020 | - | 45 | - | $4,378 | $197,020 | 1 | United International Pictures | true | false |
| 2 | - | Due Date | $191,177 | - | 69 | - | $2,770 | $191,177 | 1 | Warner Bros. | true | false |
| 3 | 1 | Saw 3D | $154,802 | -38.2% | 42 | +6 | $3,685 | $609,861 | 2 | Walt Disney Pictures | false | false |
| 4 | 2 | The Zero Hour | $142,246 | -8.7% | 45 | - | $3,161 | $1,473,277 | 5 | N/A | false | false |
| 5 | 4 | Eat Pray Love | $108,698 | -14.2% | 37 | -3 | $2,937 | $306,450 | 2 | Sony Pictures Releasing | false | false |
| 6 | 3 | Vampires Suck | $80,149 | -38.5% | 43 | +1 | $1,863 | $285,167 | 2 | 20th Century Fox International | false | false |
| 7 | 5 | Legend of the Guardians: The Owls of Ga'Hoole | $47,640 | -49% | 53 | +1 | $898 | $1,702,005 | 6 | Warner Bros. | false | false |
| 8 | - | Love Happens | $41,869 | - | 32 | - | $1,308 | $41,869 | 1 | N/A | true | false |
| 9 | 6 | The Town | $32,854 | -63.3% | 32 | -20 | $1,026 | $674,953 | 4 | Warner Bros. | false | false |
| 10 | 7 | Furry Vengeance | $28,100 | -28.2% | 23 | -2 | $1,221 | $844,800 | 10 | N/A | false | false |
| 11 | 10 | Tinker Bell and the Great Fairy Rescue | $22,377 | -1.7% | 15 | - | $1,491 | $263,910 | 7 | Walt Disney Pictures | false | false |
| 12 | 8 | The Other Guys | $14,889 | -56.4% | 15 | -14 | $992 | $780,030 | 8 | Sony Pictures Releasing | false | false |
| 13 | 12 | Las Caras del Diablo | $13,461 | -0.3% | 15 | +3 | $897 | $295,361 | 8 | N/A | false | false |
| 14 | 9 | The Sorcerer's Apprentice | $10,466 | -62.5% | 28 | -7 | $373 | $2,585,328 | 10 | Walt Disney Pictures | false | false |
| 15 | 16 | Extremos | $6,688 | -27.1% | 10 | +1 | $668 | $19,982 | 2 | N/A | false | false |
| 16 | - | Cell 211 | $5,626 | - | 3 | - | $1,875 | $15,066 | 1 | N/A | true | false |
| 17 | 20 | Despicable Me | $5,066 | +15.9% | 9 | -4 | $562 | $2,301,511 | 13 | United International Pictures | false | false |
| 18 | 11 | Piranha 3D | $4,324 | -77.8% | 9 | -11 | $480 | $377,834 | 4 | N/A | false | false |
| 19 | 18 | Cats & Dogs: The Revenge of Kitty Galore | $3,566 | -52.3% | 15 | -7 | $237 | $1,680,476 | 11 | Warner Bros. | false | false |
| 20 | 14 | The Last Airbender | $2,744 | -73.9% | 10 | -10 | $274 | $2,260,102 | 11 | United International Pictures | false | false |
| 21 | 24 | Taita Boves | $1,686 | +165.1% | 5 | +3 | $337 | $148,287 | 11 | N/A | false | false |
| 22 | 13 | Predators | $431 | -96% | 3 | -16 | $143 | $597,533 | 6 | 20th Century Fox International | false | false |
| 23 | 17 | My One and Only | $371 | -95.9% | 2 | -5 | $185 | $37,247 | 3 | N/A | false | false |
| 24 | 15 | The Box | $289 | -97.1% | 1 | -9 | $289 | $310,817 | 6 | N/A | false | false |
| 25 | 25 | Chéri | $117 | -80.9% | 1 | - | $117 | $63,958 | 6 | N/A | false | false |
