| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Deathly Hallows: Part 1 | $1,225,698 | - | 172 | - | $7,126 | $1,300,465 | 1 | Warner Bros. | true | false |
| 2 | 1 | Paranormal Activity 2 | $112,240 | -37% | 39 | -2 | $2,877 | $698,706 | 3 | United International Pictures | false | false |
| 3 | 3 | Due Date | $39,763 | -36.1% | 29 | -4 | $1,371 | $222,437 | 3 | Warner Bros. | false | false |
| 4 | 2 | Saw 3D | $29,798 | -67% | 20 | -33 | $1,489 | $665,597 | 4 | N/A | false | false |
| 5 | 4 | Legend of the Guardians: The Owls of Ga'Hoole | $27,880 | -49.8% | 29 | -15 | $961 | $1,242,819 | 7 | Warner Bros. | false | false |
| 6 | 6 | The Social Network | $21,251 | -37.4% | 17 | -7 | $1,250 | $242,729 | 4 | Sony Pictures Releasing | false | false |
| 7 | 5 | Qué pena tu vida | $21,017 | -43.5% | 23 | -7 | $913 | $436,222 | 5 | N/A | false | false |
| 8 | 8 | Eat Pray Love | $19,268 | -27.2% | 12 | -4 | $1,605 | $394,148 | 6 | Sony Pictures Releasing | false | false |
| 9 | 9 | Life as We Know It | $15,083 | -42% | 13 | -2 | $1,160 | $217,293 | 5 | Warner Bros. | false | false |
| 10 | 7 | RED | $14,770 | -53.6% | 14 | -11 | $1,055 | $121,355 | 3 | N/A | false | false |
| 11 | 10 | The Town | $7,826 | -60.1% | 9 | -12 | $869 | $146,551 | 4 | Warner Bros. | false | false |
| 12 | 12 | The Girl Who Played with Fire | $7,565 | -55.5% | 8 | -2 | $945 | $29,261 | 2 | Andes Films | false | false |
| 13 | 13 | Vampires Suck | $4,666 | -66.6% | 11 | -7 | $424 | $332,168 | 6 | 20th Century Fox International | false | false |
| 14 | 11 | Step Up 3D | $3,111 | -83.4% | 5 | -18 | $622 | $606,128 | 3 | Walt Disney Pictures | false | false |
| 15 | 14 | Hot Tub Time Machine | $2,581 | -79.5% | 6 | -6 | $430 | $19,464 | 2 | N/A | false | false |
| 16 | 19 | Resident Evil: Afterlife | $2,320 | -35% | 4 | +1 | $580 | $1,353,662 | 10 | Sony Pictures Releasing | false | false |
| 17 | 15 | Nanny McPhee Returns | $2,282 | -56% | 4 | -1 | $570 | $256,316 | 10 | United International Pictures | false | false |
| 18 | 18 | Oceans | $2,040 | -53.4% | 2 | -6 | $1,020 | $41,787 | 4 | N/A | false | false |
| 19 | 17 | Inception | $1,820 | -64.3% | 3 | - | $606 | $2,562,565 | 15 | Warner Bros. | false | false |
| 20 | 20 | Despicable Me | $1,088 | -46.5% | 3 | -1 | $362 | $1,426,890 | 17 | United International Pictures | false | false |
| 21 | 23 | Hachi: A Dog's Tale | $488 | -44.9% | 1 | -1 | $488 | $288,311 | 10 | N/A | false | false |
| 22 | 16 | It's Alive | $416 | -91.9% | 2 | -8 | $208 | $95,974 | 7 | N/A | false | false |
| 23 | 25 | Tinker Bell and the Great Fairy Rescue | $326 | -40.3% | 3 | - | $108 | $310,178 | 12 | Walt Disney Pictures | false | false |
| 24 | 26 | Grown Ups | $153 | -47.8% | 1 | -1 | $153 | $611,705 | 11 | Sony Pictures Releasing | false | false |
