| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Unstoppable | $162,689 | - | 60 | - | $2,711 | $162,689 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Life as We Know It | $123,069 | -22% | 68 | -2 | $1,809 | $620,050 | 3 | NuMetro Distribution | false | false |
| 3 | 2 | Despicable Me | $77,668 | -27% | 63 | +24 | $1,232 | $1,959,474 | 7 | United International Pictures | false | false |
| 4 | 3 | The Social Network | $60,902 | -33.6% | 40 | - | $1,522 | $199,134 | 2 | Ster-Kinekor Pictures | false | false |
| 5 | 6 | Piranha 3D | $52,567 | -25.1% | 41 | +8 | $1,282 | $303,046 | 3 | Ster-Kinekor Pictures | false | false |
| 6 | 4 | Eat Pray Love | $52,256 | -42.1% | 64 | -10 | $816 | $1,600,511 | 6 | Sony Pictures Releasing | false | false |
| 7 | 8 | You Again | $46,962 | -24.4% | 30 | - | $1,565 | $133,685 | 2 | Ster-Kinekor Pictures | false | false |
| 8 | 7 | Alpha and Omega | $44,632 | -28.2% | 50 | -1 | $892 | $352,663 | 4 | NuMetro Distribution | false | false |
| 9 | 5 | Takers 2010 Re-release | $37,912 | -48.1% | 38 | -2 | $997 | $278,547 | 3 | Ster-Kinekor Pictures | false | false |
| 10 | 10 | The Other Guys | $24,311 | -47.1% | 34 | -4 | $715 | $1,123,475 | 8 | Sony Pictures Releasing | false | false |
| 11 | 9 | The Switch | $23,456 | -49% | 33 | -4 | $710 | $496,180 | 5 | NuMetro Distribution | false | false |
| 12 | 12 | The Girl Who Played with Fire | $23,355 | -24.9% | 14 | - | $1,668 | $70,225 | 2 | NuMetro Distribution | false | false |
| 13 | - | The Crazies | $21,807 | - | 34 | - | $641 | $21,807 | 1 | United International Pictures | true | false |
| 14 | 13 | The Girl with the Dragon Tattoo | $19,852 | -12.2% | 12 | - | $1,654 | $206,621 | 5 | NuMetro Distribution | false | false |
| 15 | 11 | Charlie St. Cloud | $19,001 | -46.2% | 31 | +6 | $612 | $253,215 | 4 | United International Pictures | false | false |
| 16 | 14 | Action Replayy | $10,701 | -51.3% | 10 | - | $1,070 | $38,504 | 2 | NuMetro Distribution | false | false |
| 17 | 17 | Why Did I Get Married Too? | $9,696 | -48.8% | 15 | -7 | $646 | $526,450 | 7 | Ster-Kinekor Pictures | false | false |
| 18 | - | It's a Wonderful Afterlife | $9,023 | - | 19 | - | $474 | $9,023 | 1 | Ster-Kinekor Pictures | true | false |
| 19 | - | The Kids Are All Right | $5,729 | - | 3 | - | $1,909 | $5,729 | 1 | United International Pictures | true | false |
| 20 | - | Eyes Wide Open | $5,015 | - | 2 | - | $2,507 | $5,015 | 1 | United International Pictures | true | false |
| 21 | 18 | The Infidel | $4,728 | -50.5% | 10 | +1 | $472 | $19,288 | 2 | United International Pictures | false | false |
| 22 | 19 | The Last Airbender | $3,079 | -25.8% | 9 | +5 | $342 | $1,333,012 | 10 | United International Pictures | false | false |
