| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Deathly Hallows: Part 1 | $770,423 | - | 112 | - | $6,878 | $770,423 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Liefling | $250,545 | -9.5% | 97 | +2 | $2,582 | $662,017 | 2 | Indigenous Film Distribution | false | false |
| 3 | 3 | Unstoppable | $112,771 | -7.4% | 61 | - | $1,848 | $526,473 | 3 | NuMetro Distribution | false | false |
| 4 | 2 | RED | $107,859 | -24.2% | 45 | - | $2,396 | $321,392 | 2 | NuMetro Distribution | false | false |
| 5 | 5 | Life as We Know It | $97,394 | +0.3% | 59 | -3 | $1,650 | $901,005 | 5 | NuMetro Distribution | false | false |
| 6 | 4 | Jackass 3D | $96,082 | -3.7% | 34 | - | $2,825 | $251,076 | 2 | United International Pictures | false | false |
| 7 | 6 | Despicable Me | $53,458 | -15% | 40 | -8 | $1,336 | $2,052,590 | 9 | United International Pictures | false | false |
| 8 | 9 | You Again | $35,602 | -9.5% | 25 | -3 | $1,424 | $245,495 | 4 | Ster-Kinekor Pictures | false | false |
| 9 | 10 | Takers 2010 Re-release | $24,354 | -16.7% | 24 | -10 | $1,014 | $362,527 | 5 | Ster-Kinekor Pictures | false | false |
| 10 | 8 | Eat Pray Love | $22,972 | -41.9% | 29 | -16 | $792 | $1,678,287 | 8 | Sony Pictures Releasing | false | false |
| 11 | 7 | The Social Network | $21,768 | -47.2% | 17 | -9 | $1,280 | $310,086 | 4 | Ster-Kinekor Pictures | false | false |
| 12 | 14 | The Switch | $15,391 | -20% | 20 | -7 | $769 | $541,358 | 7 | NuMetro Distribution | false | false |
| 13 | - | Break Ke Baad | $15,019 | - | 6 | - | $2,503 | $15,019 | 1 | NuMetro Distribution | true | false |
| 14 | 13 | The Girl Who Played with Fire | $12,979 | -33.4% | 10 | -1 | $1,297 | $123,417 | 4 | NuMetro Distribution | false | false |
| 15 | 15 | The Other Guys | $12,141 | -20.9% | 17 | -4 | $714 | $1,141,590 | 10 | Sony Pictures Releasing | false | false |
| 16 | 11 | The Girl with the Dragon Tattoo | $10,747 | -60.3% | 11 | -1 | $977 | $248,099 | 7 | NuMetro Distribution | false | false |
| 17 | 12 | Battle for Terra | $9,736 | -59.3% | 20 | -1 | $486 | $39,905 | 2 | Ster-Kinekor Pictures | false | false |
| 18 | 16 | The Crazies | $8,908 | -41.8% | 15 | -19 | $593 | $63,849 | 3 | United International Pictures | false | false |
| 19 | - | Coco Chanel & Igor Stravinsky | $8,419 | - | 6 | - | $1,403 | $8,419 | 1 | United International Pictures | true | false |
| 20 | 18 | Charlie St. Cloud | $6,177 | -35.2% | 16 | -6 | $386 | $273,411 | 6 | United International Pictures | false | false |
| 21 | 21 | The Kids Are All Right | $4,550 | -5.3% | 3 | - | $1,516 | $20,513 | 3 | United International Pictures | false | false |
| 22 | 20 | Why Did I Get Married Too? | $4,258 | -27.8% | 9 | -1 | $473 | $529,877 | 9 | Ster-Kinekor Pictures | false | false |
| 23 | 17 | Piranha 3D | $4,242 | -60.1% | 3 | -6 | $1,414 | $336,694 | 5 | Ster-Kinekor Pictures | false | false |
| 24 | 22 | Eyes Wide Open | $2,696 | -35.1% | 2 | - | $1,348 | $15,974 | 3 | United International Pictures | false | false |
| 25 | - | The Infidel | $81 | - | 1 | - | $81 | $24,392 | 4 | United International Pictures | false | false |
