| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Escort in Love | $951,584 | -55.5% | 373 | -112 | $2,551 | $9,232,581 | 3 | 01 Distribution | false | false |
| 2 | - | Just Go with It | $681,213 | - | 231 | - | $2,948 | $681,213 | 1 | Sony Pictures Releasing | true | false |
| 3 | - | Hop | $651,647 | - | 333 | - | $1,956 | $651,647 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | Boris - Il film | $602,611 | - | 331 | - | $1,820 | $602,611 | 1 | 01 Distribution | true | false |
| 5 | 2 | No Strings Attached | $401,826 | -58.8% | 224 | -34 | $1,793 | $1,792,436 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | - | Kick-Ass | $288,478 | - | 191 | - | $1,510 | $288,478 | 1 | Eagle Pictures | true | false |
| 7 | - | The End Is My Beginning | $268,294 | - | 75 | - | $3,577 | $270,013 | 1 | Fandango | true | false |
| 8 | 4 | Sucker Punch | $201,812 | -71.4% | 194 | -85 | $1,040 | $1,168,446 | 2 | Warner Bros. | false | false |
| 9 | - | The Ward | $201,437 | - | 117 | - | $1,721 | $201,437 | 1 | BIM Distribuzione | true | false |
| 10 | 3 | Amici miei - Come tutto ebbe inizio | $165,494 | -79% | 139 | -234 | $1,190 | $4,653,493 | 3 | Filmauro | false | false |
| 11 | 6 | Dylan Dog: Dead of Night | $158,337 | -70.8% | 132 | -106 | $1,199 | $3,281,533 | 3 | Moviemax | false | false |
| 12 | 9 | Frozen | $149,478 | -59.2% | 91 | -11 | $1,642 | $644,621 | 2 | N/A | false | false |
| 13 | 11 | The King's Speech | $142,479 | -53.8% | 100 | -14 | $1,424 | $11,833,276 | 10 | Eagle Pictures | false | false |
| 14 | 5 | Rango | $131,591 | -79.3% | 198 | -118 | $664 | $6,928,666 | 4 | Universal Pictures International (UPI) | false | false |
| 15 | 8 | The Rite | $99,117 | -75% | 66 | -94 | $1,501 | $4,975,704 | 4 | Warner Bros. | false | false |
| 16 | 14 | Never Let Me Go | $86,327 | -64% | 78 | -21 | $1,106 | $428,694 | 2 | 20th Century Fox International | false | false |
| 17 | 13 | Silvio Forever | $83,013 | -67.7% | 89 | -15 | $932 | $450,518 | 2 | Lucky Red | false | false |
| 18 | 7 | Gnomeo & Juliet | $78,366 | -81% | 179 | -96 | $437 | $2,106,046 | 3 | Walt Disney Pictures | false | false |
| 19 | 15 | The Kids Are All Right | $78,212 | -58.1% | 46 | -35 | $1,700 | $1,718,388 | 4 | Lucky Red | false | false |
| 20 | 16 | Black Swan | $67,641 | -58.4% | 57 | -29 | $1,186 | $8,355,517 | 7 | 20th Century Fox International | false | false |
| 21 | 10 | The Last Fashion Show | $47,451 | -87% | 131 | -194 | $362 | $533,871 | 2 | Medusa Distribuzione | false | false |
| 22 | - | Poetry | $46,840 | - | 22 | - | $2,129 | $47,255 | 1 | N/A | true | false |
| 23 | 17 | La vita facile | $38,054 | -56.2% | 33 | -23 | $1,153 | $3,735,320 | 5 | Medusa Distribuzione | false | false |
| 24 | 12 | StreetDance 2 | $35,697 | -87.5% | 28 | -132 | $1,274 | $1,779,656 | 3 | Eagle Pictures | false | false |
| 25 | 18 | Sorelle mai | $33,186 | -58.1% | 28 | -9 | $1,185 | $339,137 | 3 | Teodora Film | false | false |
| 26 | 20 | The Jewel | $26,462 | -62.5% | 18 | -8 | $1,470 | $1,271,312 | 5 | BIM Distribuzione | false | false |
| 27 | - | Questo mondo è per te | $25,539 | - | 5 | - | $5,107 | $27,019 | 1 | N/A | true | false |
| 28 | 19 | The Fighter | $21,214 | -72.8% | 21 | -18 | $1,010 | $3,132,092 | 5 | Eagle Pictures | false | false |
| 29 | 21 | True Grit | $15,158 | -31.3% | 19 | +7 | $797 | $4,148,917 | 7 | Universal Pictures International (UPI) | false | false |
| 30 | - | L'affare Bonnard | $11,610 | - | 7 | - | $1,658 | $11,610 | 1 | N/A | true | false |
| 31 | 26 | Another Year | $11,449 | -21.4% | 6 | +2 | $1,908 | $1,146,630 | 9 | BIM Distribuzione | false | false |
| 32 | 24 | Winter's Bone | $9,349 | -47.4% | 9 | - | $1,038 | $502,833 | 7 | Bolero Film | false | false |
| 33 | - | Of Gods and Men | $5,438 | - | 3 | - | $1,812 | $1,811,290 | 24 | Lucky Red | false | false |
| 34 | 32 | 6 Souls | $5,384 | -17.9% | 2 | -1 | $2,692 | $689,365 | 6 | Moviemax | false | false |
| 35 | 23 | On Tour | $5,097 | -71.4% | 5 | -6 | $1,019 | $62,545 | 3 | N/A | false | false |
| 36 | 27 | Beyond | $3,870 | -68.9% | 3 | -8 | $1,290 | $69,480 | 3 | Sacher Distribuzione | false | false |
| 37 | - | Hereafter | $3,780 | - | 6 | - | $630 | $11,031,906 | 13 | Warner Bros. | false | false |
| 38 | 35 | Women Vs Men | $3,294 | -47% | 4 | -2 | $823 | $16,478,994 | 9 | Medusa Distribuzione | false | false |
| 39 | 42 | 127 Hours | $3,168 | -35% | 4 | - | $792 | $908,310 | 6 | 20th Century Fox International | false | false |
| 40 | 28 | Barney's Version | $3,098 | -70.9% | 4 | - | $774 | $3,643,341 | 12 | Medusa Distribuzione | false | false |
| 41 | 44 | In a Better World | $2,836 | -37% | 4 | +2 | $709 | $738,711 | 17 | Teodora Film | false | false |
| 42 | 25 | The Ages of Love | $2,797 | -83.8% | 4 | -11 | $699 | $9,416,400 | 6 | Filmauro | false | false |
| 43 | 45 | Biutiful | $2,745 | -34.6% | 3 | -1 | $915 | $458,791 | 9 | Universal Pictures International (UPI) | false | false |
| 44 | 31 | Piranha 3D | $2,216 | -71.7% | 2 | -5 | $1,108 | $2,025,594 | 5 | BIM Distribuzione | false | false |
| 45 | 36 | The Salt of Life | $2,168 | -63.5% | 3 | - | $722 | $1,197,320 | 8 | 01 Distribution | false | false |
| 46 | 49 | Unknown | $1,849 | -42.3% | 3 | - | $616 | $2,294,900 | 6 | Warner Bros. | false | false |
| 47 | 34 | The Immature | $1,849 | -71.3% | 2 | -2 | $924 | $21,486,350 | 11 | Medusa Distribuzione | false | false |
| 48 | - | Love & Other Drugs | $1,639 | - | 5 | - | $327 | $5,050,555 | 7 | Medusa Distribuzione | false | false |
| 49 | - | Kill Bill: Vol. 1 | $1,621 | - | 1 | - | $1,621 | $7,610,643 | 389 | N/A | false | false |
| 50 | - | Up | $1,607 | - | 1 | - | $1,607 | $22,494,067 | 77 | Walt Disney Pictures | false | false |
