| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Deathly Hallows: Part 2 | $79,290 | - | 9 | - | $8,810 | $138,549 | 1 | ACME | true | false |
| 2 | 1 | Transformers: Dark of the Moon | $20,489 | -36.6% | 13 | - | $1,576 | $322,207 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Horrible Bosses | $14,930 | +9.2% | 8 | - | $1,866 | $46,467 | 2 | ACME | false | false |
| 4 | 3 | Kung Fu Panda 2 | $7,979 | -4.5% | 15 | - | $531 | $439,516 | 7 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Mr. Popper's Penguins | $5,460 | +17.6% | 8 | - | $682 | $84,285 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | The Hangover Part II | $5,446 | +55% | 8 | - | $680 | $350,110 | 8 | ACME | false | false |
| 7 | 5 | Pirates of the Caribbean: On Stranger Tides | $3,163 | -16.6% | 6 | -2 | $527 | $462,320 | 9 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Something Borrowed | $2,231 | -16.3% | 6 | - | $371 | $29,564 | 3 | ACME | false | false |
| 9 | 8 | Rio | $1,616 | -17.4% | 6 | -3 | $269 | $404,247 | 13 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Super 8 | $1,392 | -11.2% | 6 | - | $232 | $57,713 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | - | I Love You Too | $1,307 | - | 2 | - | $653 | $1,307 | 1 | N/A | true | false |
| 12 | 10 | Limitless | $1,016 | +13.1% | 4 | - | $254 | $73,610 | 6 | Garsu Pasaulio Irasai | false | false |
| 13 | - | Biutiful | $802 | - | 1 | - | $802 | $42,350 | 23 | ACME | false | false |
| 14 | 26 | Water for Elephants | $282 | +754.5% | 1 | - | $282 | $99,183 | 14 | Universal Pictures International (UPI) | false | false |
| 15 | - | The King's Speech | $216 | - | 1 | - | $216 | $106,241 | 26 | ACME | false | false |
| 16 | - | Despicable Me | $195 | - | 1 | - | $195 | $519,950 | 40 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | Tangled | $179 | +1.7% | 2 | -2 | $89 | $429,842 | 25 | Universal Pictures International (UPI) | false | false |
| 18 | 23 | Up | $127 | +182.2% | 2 | +1 | $63 | $429,129 | 100 | Universal Pictures International (UPI) | false | false |
| 19 | 19 | Shrek Forever After | $109 | +109.6% | 1 | - | $109 | $681,305 | 59 | Universal Pictures International (UPI) | false | false |
| 20 | - | Megamind | $104 | - | 1 | - | $104 | $259,185 | 31 | Universal Pictures International (UPI) | false | false |
