| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Horrible Bosses | $624,768 | - | 262 | - | $2,384 | $981,364 | 1 | Warner Bros. | true | false |
| 2 | 1 | Mr. Popper's Penguins | $602,477 | -36.1% | 276 | +30 | $2,182 | $2,400,481 | 2 | 20th Century Fox International | false | false |
| 3 | - | Bridesmaids | $419,745 | - | 249 | - | $1,685 | $516,673 | 1 | United International Pictures | true | false |
| 4 | - | Conan the Barbarian | $413,965 | - | 320 | - | $1,293 | $535,435 | 1 | 01 Distribution | true | false |
| 5 | - | Stan Helsing | $345,952 | - | 184 | - | $1,880 | $659,071 | 1 | Eagle Pictures | true | false |
| 6 | - | Green Lantern | $187,380 | - | 241 | - | $777 | $187,715 | - | Warner Bros. | - | false |
| 7 | 2 | Captain America: The First Avenger | $150,969 | -44.6% | 168 | -131 | $898 | $8,763,741 | 5 | United International Pictures | false | false |
| 8 | 3 | Harry Potter and the Deathly Hallows: Part 2 | $127,342 | -45.5% | 164 | -167 | $776 | $31,733,698 | 6 | Warner Bros. | false | false |
| 9 | 4 | Hanna | $107,771 | -38.2% | 190 | -41 | $567 | $486,053 | 2 | Sony Pictures Releasing | false | false |
| 10 | 5 | Tekken | $47,670 | -53.7% | 106 | -43 | $449 | $722,304 | 3 | N/A | false | false |
| 11 | 9 | Cars 2 | $23,312 | -44.8% | 41 | -80 | $568 | $14,986,897 | 9 | Walt Disney Pictures | false | false |
| 12 | 8 | Grease 2010 Sing-a-long | $20,278 | -63% | 78 | -51 | $259 | $122,251 | 2 | Nexo | false | false |
| 13 | - | Prom | $18,980 | - | 14 | - | $1,355 | $18,980 | 1 | Walt Disney Pictures | true | false |
| 14 | 10 | Almeno tu nell'universo | $16,178 | -44.9% | 90 | -10 | $179 | $76,708 | 2 | Lucky Red | false | false |
| 15 | 16 | Zack and Miri Make a Porno | $15,559 | +17.3% | 7 | - | $2,222 | $630,524 | 12 | N/A | false | false |
| 16 | 15 | The Women on the 6th Floor | $14,582 | -30.6% | 17 | -7 | $857 | $1,472,549 | 11 | N/A | false | false |
| 17 | 11 | Diary of a Wimpy Kid: Rodrick Rules | $9,469 | -65.1% | 33 | -52 | $286 | $180,425 | 3 | 20th Century Fox International | false | false |
| 18 | 12 | Transformers: Dark of the Moon | $8,599 | -67.8% | 12 | -29 | $716 | $12,398,269 | 8 | United International Pictures | false | false |
| 19 | - | The Tree of Life | $7,679 | - | 5 | - | $1,535 | $4,007,062 | 14 | 01 Distribution | false | false |
| 20 | - | Snow Flower and the Secret Fan | $7,558 | - | 7 | - | $1,079 | $550,573 | 7 | Eagle Pictures | false | false |
| 21 | 17 | Diary of a Wimpy Kid | $6,397 | -45.9% | 21 | -15 | $304 | $555,688 | 4 | 20th Century Fox International | false | false |
| 22 | - | The Kid with a Bike | $6,185 | - | 7 | - | $883 | $1,105,511 | 14 | Lucky Red | false | false |
| 23 | - | RED | $6,064 | - | 3 | - | $2,021 | $4,037,945 | 15 | Medusa Distribuzione | false | false |
| 24 | - | We Have a Pope | $5,802 | - | 9 | - | $644 | $8,390,652 | 19 | 01 Distribution | false | false |
| 25 | 19 | War Games | $4,951 | -17.6% | 6 | -6 | $825 | $322,562 | 5 | Bolero Film | false | false |
| 26 | 13 | Second Chance | $4,447 | -79.8% | 12 | -36 | $370 | $1,449,548 | 6 | Moviemax | false | false |
| 27 | - | Season of the Witch | $4,083 | - | 4 | - | $1,020 | $4,383,131 | 10 | Medusa Distribuzione | false | false |
| 28 | - | Escort in Love | $4,003 | - | 8 | - | $500 | $11,471,250 | 23 | 01 Distribution | false | false |
| 29 | - | The Conspirator | $3,443 | - | 4 | - | $860 | $567,558 | 9 | 01 Distribution | false | false |
| 30 | - | The Adjustment Bureau | $2,399 | - | 4 | - | $599 | $2,810,727 | 10 | Universal Pictures International (UPI) | false | false |
| 31 | - | The King's Speech | $1,499 | - | 5 | - | $299 | $12,493,249 | 30 | Eagle Pictures | false | false |
| 32 | - | Hereafter | $1,476 | - | 2 | - | $738 | $11,240,698 | 33 | Warner Bros. | false | false |
| 33 | - | Barney's Version | $1,452 | - | 2 | - | $726 | $3,764,747 | 32 | Medusa Distribuzione | false | false |
| 34 | - | Seraphine | $1,439 | - | 1 | - | $1,439 | $169,425 | 44 | One Movie | false | false |
| 35 | 20 | Welcome to the South | $1,437 | -74.8% | 2 | -4 | $718 | $43,015,634 | 47 | Medusa Distribuzione | false | false |
| 36 | - | Women Vs Men | $1,401 | - | 2 | - | $700 | $16,719,346 | 29 | Medusa Distribuzione | false | false |
| 37 | - | Il diario di Matilde Manzoni | $1,398 | - | 1 | - | $1,398 | $21,416 | 465 | N/A | false | false |
| 38 | - | Corpo Celeste 2011 Re-release | $1,341 | - | 3 | - | $447 | $306,413 | 13 | N/A | false | false |
| 39 | - | Dancing Dreams | $1,299 | - | 2 | - | $649 | $1,299 | 1 | N/A | true | false |
| 40 | - | Black Swan | $1,079 | - | 3 | - | $359 | $8,658,046 | 27 | 20th Century Fox International | false | false |
| 41 | - | The Hunter | $1,074 | - | 2 | - | $537 | $21,652 | 10 | Fandango | false | false |
| 42 | 18 | In the Market | $1,051 | -87.6% | 4 | - | $262 | $69,358 | 2 | N/A | false | false |
| 43 | - | The Immature | $978 | - | 2 | - | $489 | $21,858,834 | 31 | Medusa Distribuzione | false | false |
| 44 | - | In a Better World | $975 | - | 3 | - | $325 | $807,897 | 37 | Teodora Film | false | false |
| 45 | - | X-Men: First Class | $942 | - | 2 | - | $471 | $3,982,424 | 11 | 20th Century Fox International | false | false |
| 46 | - | The First Assignment | $927 | - | 1 | - | $927 | $252,959 | 16 | Teodora Film | false | false |
| 47 | - | Vanishing on 7th Street | $901 | - | 1 | - | $901 | $46,957 | 4 | One Movie | false | false |
| 48 | - | A Quiet Life | $890 | - | 1 | - | $890 | $2,021,470 | 42 | 01 Distribution | false | false |
| 49 | - | Il pezzo mancante | $824 | - | 1 | - | $824 | $33,181 | 10 | N/A | false | false |
