| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Zookeeper | $1,879,199 | - | 252 | - | $7,457 | $2,020,334 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Horrible Bosses | $1,546,556 | -33.2% | 337 | -5 | $4,589 | $9,156,238 | 3 | Warner Bros. | false | false |
| 3 | 2 | Red Dog | $1,309,251 | -25.9% | 268 | +8 | $4,885 | $15,438,987 | 6 | Roadshow Films | false | false |
| 4 | 3 | The Help | $1,249,258 | +12.2% | 280 | - | $4,461 | $3,571,389 | 2 | Walt Disney Pictures | false | false |
| 5 | - | The Change-Up | $1,171,425 | - | 220 | - | $5,324 | $1,191,081 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 4 | Final Destination 5 | $616,430 | -40% | 159 | +1 | $3,876 | $2,015,795 | 2 | Warner Bros. | false | false |
| 7 | - | The Smurfs | $571,695 | - | 117 | - | $4,886 | $823,032 | - | Sony Pictures Releasing | - | false |
| 8 | 5 | Friends with Benefits | $460,039 | -42.2% | 211 | -36 | $2,180 | $7,187,293 | 4 | Sony Pictures Releasing | false | false |
| 9 | 8 | One Day | $401,109 | -33.8% | 163 | - | $2,460 | $1,252,184 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Rise of the Planet of the Apes | $329,009 | -47.2% | 138 | -50 | $2,384 | $14,965,846 | 6 | 20th Century Fox International | false | false |
| 11 | 6 | Cowboys & Aliens | $324,819 | -53.2% | 202 | -41 | $1,608 | $5,406,659 | 4 | Paramount Pictures International | false | false |
| 12 | 9 | The Guard | $281,111 | -10.6% | 65 | +17 | $4,324 | $1,200,820 | 3 | Paramount Pictures International | false | false |
| 13 | 10 | Harry Potter and the Deathly Hallows: Part 2 | $184,370 | -37.9% | 82 | -50 | $2,248 | $54,608,697 | 9 | Warner Bros. | false | false |
| 14 | 13 | Jane Eyre | $145,098 | -18.6% | 82 | -20 | $1,769 | $3,212,043 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 15 | Beginners | $95,709 | -21.6% | 26 | +1 | $3,681 | $545,696 | 3 | Hopscotch Films | false | false |
| 16 | - | Mere Brother Ki Dulhan | $95,121 | - | 14 | - | $6,794 | $95,121 | 1 | Mind Blowing Films | true | false |
| 17 | - | Submarine | $92,323 | - | 18 | - | $5,129 | $114,630 | 1 | Madman Entertainment | true | false |
| 18 | 11 | Green Lantern | $89,999 | -67.2% | 71 | -109 | $1,267 | $7,006,138 | 5 | Warner Bros. | false | false |
| 19 | 16 | Senna | $74,247 | -36.1% | 48 | +5 | $1,546 | $1,334,411 | 5 | Universal Pictures International (UPI) | false | false |
| 20 | - | 13 Assassins | $51,114 | - | 10 | - | $5,111 | $72,584 | 1 | Icon Film Distribution | true | false |
