| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 21 Jump Street | $4,312,361 | - | 300 | - | $14,374 | $4,382,703 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | John Carter | $1,668,924 | -49% | 410 | +164 | $4,070 | $6,076,444 | 2 | Walt Disney Pictures | false | false |
| 3 | - | Ghost Rider: Spirit of Vengeance | $877,077 | - | 239 | - | $3,669 | $877,077 | 1 | Warner Bros. | true | false |
| 4 | 2 | Project X | $557,110 | -52.1% | 207 | +16 | $2,691 | $4,054,273 | 3 | Warner Bros. | false | false |
| 5 | - | Margin Call | $473,441 | - | 57 | - | $8,305 | $510,252 | 1 | Becker Film Group | true | false |
| 6 | 3 | Contraband | $376,924 | -51% | 192 | -23 | $1,963 | $5,409,971 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 4 | This Means War | $346,330 | -51.4% | 165 | -42 | $2,098 | $8,290,369 | 5 | 20th Century Fox International | false | false |
| 8 | - | The Rum Diary | $334,384 | - | 67 | - | $4,990 | $393,300 | 1 | 20th Century Fox International | true | false |
| 9 | 5 | The Vow | $305,958 | -47.4% | 187 | -33 | $1,636 | $11,596,474 | 6 | Sony Pictures Releasing | false | false |
| 10 | 7 | The Artist | $303,445 | -29.4% | 154 | +26 | $1,970 | $4,074,162 | 7 | Roadshow Films | false | false |
| 11 | 9 | Hugo | $216,876 | -30.8% | 162 | +19 | $1,338 | $10,799,544 | 10 | Paramount Pictures International | false | false |
| 12 | 6 | Safe House | $215,868 | -52.5% | 117 | -54 | $1,845 | $9,000,274 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 10 | My Week with Marilyn | $188,262 | -22.2% | 83 | +22 | $2,268 | $2,594,023 | 5 | Roadshow Films | false | false |
| 14 | 12 | A Separation | $177,809 | -2.9% | 34 | +9 | $5,229 | $863,156 | 3 | Entertainment One | false | false |
| 15 | 8 | The Devil Inside | $136,392 | -66.2% | 133 | -36 | $1,025 | $1,692,231 | 3 | Paramount Pictures International | false | false |
| 16 | 11 | Headhunters | $100,726 | -49.9% | 39 | - | $2,582 | $420,230 | 2 | Rialto Distribution | false | false |
| 17 | 17 | Tinker Tailor Soldier Spy | $69,489 | -42% | 61 | -10 | $1,139 | $6,919,623 | 9 | Universal Pictures International (UPI) | false | false |
| 18 | - | Verdi: Ernani | $68,714 | - | 26 | - | $2,642 | $68,714 | 1 | Sharmill Films | true | false |
| 19 | 15 | The Descendants | $67,684 | -46.8% | 55 | -35 | $1,230 | $15,947,488 | 10 | 20th Century Fox International | false | false |
| 20 | 20 | Journey 2: The Mysterious Island | $63,167 | -9.1% | 62 | -14 | $1,018 | $7,547,137 | 9 | Warner Bros. | false | false |
