| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Grudge 2 | $22,000,000 | $20,825,300 | -$1,174,700 | -5.3% | 3,211 | $22,000,000 | $20,825,300 | 1 | Sony Pictures Releasing | - |
| 2 | 2 | - | The Departed | $18,675,000 | $19,034,294 | +$359,294 | +1.9% | 3,017 | $56,626,000 | $56,985,185 | 2 | Warner Bros. | - |
| 3 | 3 | - | Man of the Year | $12,550,000 | $12,299,380 | -$250,620 | -2% | 2,515 | $12,550,000 | $12,299,380 | 1 | Universal Pictures | - |
| 4 | 4 | - | Open Season | $11,000,000 | $11,112,795 | +$112,795 | +1% | 3,687 | $59,154,000 | $59,267,065 | 3 | Sony Pictures Releasing | - |
| 5 | 5 | - | The Texas Chainsaw Massacre: The Beginning | $7,750,000 | - | - | - | 2,820 | $30,457,000 | - | 2 | New Line Cinema | - |
| 6 | 6 | - | The Marine | $7,000,000 | $7,138,774 | +$138,774 | +2% | 2,545 | $7,000,000 | $7,138,774 | 1 | Twentieth Century Fox | - |
| 7 | 7 | - | The Guardian | $5,853,000 | $5,866,998 | +$13,998 | +0.2% | 3,044 | $41,119,000 | $41,132,922 | 3 | Walt Disney Studios Motion Pictures | - |
| 8 | 8 | - | Employee of the Month | $5,600,000 | $5,271,088 | -$328,912 | -5.9% | 2,579 | $19,910,000 | $19,581,504 | 2 | Lionsgate Films | - |
| 9 | 9 | - | One Night with the King | $4,326,000 | - | - | - | 909 | $4,326,000 | - | 1 | 8x Entertainment | - |
| 10 | 10 | - | Jackass Number Two | $3,334,000 | $3,329,091 | -$4,909 | -0.1% | 2,330 | $68,383,000 | $68,377,686 | 4 | Paramount Pictures | - |
| 11 | 11 | - | The Illusionist | $1,426,000 | $1,374,959 | -$51,041 | -3.6% | 825 | $36,260,000 | $36,242,974 | 9 | Yari Film Group Releasing | - |
| 12 | 12 | - | School for Scoundrels | $1,257,000 | $1,301,346 | +$44,346 | +3.5% | 1,406 | $16,323,000 | $16,367,023 | 3 | - | - |
| 13 | 13 | - | The Queen | $1,020,000 | - | - | - | 46 | $1,859,000 | - | 3 | Miramax | - |
| 14 | 14 | - | Fearless | $969,000 | - | - | - | 886 | $23,526,000 | - | 4 | Rogue Pictures | - |
| 15 | 15 | - | Little Miss Sunshine | $875,000 | $872,422 | -$2,578 | -0.3% | 505 | $56,365,000 | $56,362,905 | 12 | - | - |
| 16 | 16 | - | Facing the Giants | $859,000 | - | - | - | 347 | $4,073,000 | - | 3 | IDP Distribution | - |
| 17 | 17 | - | Gridiron Gang | $800,000 | $772,551 | -$27,449 | -3.4% | 1,174 | $38,001,000 | $37,973,797 | 5 | Sony Pictures Releasing | - |
| 18 | 19 | +1 | The Last King of Scotland | $605,000 | $611,129 | +$6,129 | +1% | 104 | $1,264,000 | $1,270,711 | 3 | - | - |
| 19 | 20 | +1 | The Science of Sleep | $525,000 | $497,940 | -$27,060 | -5.2% | 243 | $3,509,000 | $3,481,693 | 4 | Warner Independent Pictures (WIP) | - |
| 20 | 21 | +1 | Infamous | $435,000 | $452,966 | +$17,966 | +4.1% | 179 | $435,000 | $452,966 | 1 | Warner Independent Pictures (WIP) | - |
| 21 | 23 | +2 | Barnyard | $245,000 | $258,892 | +$13,892 | +5.7% | 392 | $72,093,000 | $72,106,304 | 11 | Paramount Pictures | - |
| 22 | 28 | +6 | Shortbus | $204,000 | - | - | - | 25 | $402,000 | - | 2 | THINKFilm | - |
| 23 | 30 | +7 | Keeping Mum | $195,000 | $176,821 | -$18,179 | -9.3% | 74 | $839,000 | $820,301 | 5 | THINKFilm | - |
| 24 | 34 | +10 | The Black Dahlia | $144,000 | $137,765 | -$6,235 | -4.3% | 224 | $22,419,000 | $22,412,530 | 5 | Universal Pictures | - |
| 25 | 35 | +10 | The Last Kiss | $142,000 | $137,527 | -$4,473 | -3.2% | 149 | $11,507,000 | $11,502,628 | 5 | DreamWorks | - |
| 26 | 43 | +17 | The U.S. vs. John Lennon | $85,000 | $91,604 | +$6,604 | +7.8% | 58 | $697,000 | $703,206 | 5 | Lionsgate Films | - |
| 27 | 45 | +18 | Little Children | $84,000 | $84,551 | +$551 | +0.7% | 5 | $230,000 | $230,497 | 2 | New Line Cinema | - |
| 28 | 48 | +20 | Half Nelson | $76,900 | $75,295 | -$1,605 | -2.1% | 80 | $2,508,000 | $2,506,509 | 10 | THINKFilm | - |
| 29 | 53 | +24 | Sweet Land | $44,000 | $41,860 | -$2,140 | -4.9% | 2 | $44,000 | $41,860 | 1 | Libero | - |
| 30 | 63 | +33 | Driving Lessons | $25,800 | $22,603 | -$3,197 | -12.4% | 8 | $25,800 | $22,603 | 1 | Sony Pictures Classics | - |
| 31 | 64 | +33 | Crank | $22,000 | $20,948 | -$1,052 | -4.8% | 36 | $27,831,000 | $27,829,874 | 7 | Lionsgate Films | - |
| 32 | 69 | +37 | Deliver Us from Evil | $16,000 | $15,656 | -$344 | -2.2% | 4 | $16,000 | $15,656 | 1 | Lionsgate Films | - |
| 33 | 84 | +51 | Tideland | $8,350 | $7,276 | -$1,074 | -12.9% | 1 | $8,350 | $7,276 | 1 | THINKFilm | - |
