| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Night at the Museum | $30,800,000 | $30,433,781 | -$366,219 | -1.2% | 3,685 | $30,800,000 | $30,433,781 | 1 | Twentieth Century Fox | - |
| 2 | 2 | - | The Pursuit of Happyness | $15,000,000 | $14,817,371 | -$182,629 | -1.2% | 2,863 | $53,287,000 | $53,104,266 | 2 | Sony Pictures Releasing | - |
| 3 | 3 | - | Rocky Balboa | $12,540,000 | $12,158,168 | -$381,832 | -3% | 3,017 | $22,233,000 | $21,851,382 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 4 | 4 | - | The Good Shepherd | $9,979,000 | $9,912,110 | -$66,890 | -0.7% | 2,215 | $9,979,000 | $9,912,110 | 1 | Universal Pictures | - |
| 5 | 5 | - | Charlotte's Web | $8,000,000 | $7,566,306 | -$433,694 | -5.4% | 3,728 | $26,809,000 | $26,375,772 | 2 | Paramount Pictures | - |
| 6 | 6 | - | Eragon | $7,150,000 | $7,006,467 | -$143,533 | -2% | 3,030 | $37,645,000 | $37,502,169 | 2 | Twentieth Century Fox | - |
| 7 | 7 | - | We Are Marshall | $6,640,000 | $6,114,264 | -$525,736 | -7.9% | 2,606 | $7,745,000 | $7,214,264 | 1 | Warner Bros. | - |
| 8 | 8 | - | Happy Feet | $5,145,000 | $5,163,474 | +$18,474 | +0.4% | 2,565 | $159,101,000 | $159,119,637 | 6 | Warner Bros. | - |
| 9 | 9 | - | The Holiday | $5,000,000 | $4,839,108 | -$160,892 | -3.2% | 2,635 | $35,093,000 | $34,932,070 | 3 | Sony Pictures Releasing | - |
| 10 | 10 | - | The Nativity Story | $4,650,000 | - | - | - | 1,824 | $31,335,000 | - | 4 | New Line Cinema | - |
| 11 | 11 | - | Casino Royale | $3,100,000 | $3,143,720 | +$43,720 | +1.4% | 1,588 | $143,669,000 | $143,713,120 | 6 | Sony Pictures Releasing | - |
| 12 | 12 | - | Blood Diamond | $3,040,000 | $3,126,379 | +$86,379 | +2.8% | 1,920 | $25,043,000 | $25,129,129 | 3 | Warner Bros. | - |
| 13 | 13 | - | Apocalypto | $3,018,000 | $2,868,725 | -$149,275 | -4.9% | 2,144 | $34,742,000 | $34,592,881 | 3 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | The Santa Clause 3: The Escape Clause | $1,108,000 | $1,165,697 | +$57,697 | +5.2% | 801 | $82,221,000 | $82,278,441 | 8 | Walt Disney Studios Motion Pictures | - |
| 15 | 16 | +1 | Deja Vu | $716,000 | $743,704 | +$27,704 | +3.9% | 839 | $59,835,000 | $59,862,537 | 5 | Walt Disney Studios Motion Pictures | - |
| 16 | 17 | +1 | Borat | $560,000 | $619,066 | +$59,066 | +10.5% | 458 | $124,244,000 | $124,303,063 | 8 | Twentieth Century Fox | - |
| 17 | 18 | +1 | Deck the Halls | $550,000 | $536,425 | -$13,575 | -2.5% | 751 | $34,118,000 | $34,104,717 | 5 | Twentieth Century Fox | - |
| 18 | 19 | +1 | Volver | $519,000 | $453,880 | -$65,120 | -12.5% | 115 | $3,544,000 | $3,478,836 | 8 | Sony Pictures Classics | - |
| 19 | 27 | +8 | Curse of the Golden Flower | $489,000 | $184,000 | -$305,000 | -62.4% | 60 | $503,000 | $344,000 | 1 | Sony Pictures Classics | - |
| 20 | 26 | +6 | The Queen | $433,000 | $190,000 | -$243,000 | -56.1% | 302 | $26,471,000 | $26,350,000 | 13 | Miramax | - |
| 21 | 21 | - | Babel | $308,000 | $312,218 | +$4,218 | +1.4% | 208 | $18,871,000 | $18,874,554 | 9 | Paramount Vantage | - |
| 22 | 30 | +8 | Letters from Iwo Jima | $76,500 | $89,097 | +$12,597 | +16.5% | 5 | $116,000 | $128,842 | 1 | Warner Bros. | - |
| 23 | 35 | +12 | The Painted Veil | $47,000 | $51,086 | +$4,086 | +8.7% | 4 | $68,000 | $72,230 | 1 | Warner Independent Pictures (WIP) | - |
| 24 | 38 | +14 | Venus | $36,200 | $35,604 | -$596 | -1.6% | 3 | $42,000 | $41,367 | 1 | Miramax | - |
