| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | I Now Pronounce You Chuck & Larry | $34,775,000 | $34,233,750 | -$541,250 | -1.6% | 3,495 | $34,775,000 | $34,233,750 | 1 | Universal Pictures | - |
| 2 | 2 | - | Harry Potter and the Order of the Phoenix | $32,185,000 | $32,511,350 | +$326,350 | +1% | 4,285 | $207,541,000 | $207,866,865 | 2 | Warner Bros. | - |
| 3 | 3 | - | Hairspray | $27,800,000 | - | - | - | 3,121 | $27,800,000 | - | 1 | New Line Cinema | - |
| 4 | 4 | - | Transformers | $20,506,000 | $20,514,497 | +$8,497 | <0.1% | 3,762 | $262,969,000 | $262,978,000 | 3 | DreamWorks | - |
| 5 | 5 | - | Ratatouille | $11,000,000 | $10,899,179 | -$100,821 | -0.9% | 3,402 | $165,628,000 | $165,519,955 | 4 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | Live Free or Die Hard | $7,300,000 | $7,101,638 | -$198,362 | -2.7% | 2,727 | $116,466,000 | $116,267,866 | 4 | Twentieth Century Fox | - |
| 7 | 7 | - | License to Wed | $3,760,000 | $3,577,230 | -$182,770 | -4.9% | 2,525 | $38,678,000 | $38,495,133 | 3 | Warner Bros. | - |
| 8 | 8 | - | 1408 | $2,600,000 | $2,621,194 | +$21,194 | +0.8% | 1,451 | $67,500,000 | $67,453,524 | 5 | - | - |
| 9 | 9 | - | Evan Almighty | $2,455,000 | $2,552,890 | +$97,890 | +4% | 1,779 | $93,469,000 | $93,567,015 | 5 | Universal Pictures | - |
| 10 | 10 | - | Knocked Up | $2,318,000 | $2,292,640 | -$25,360 | -1.1% | 1,288 | $142,725,000 | $142,698,885 | 8 | Universal Pictures | - |
| 11 | 11 | - | Sicko | $1,900,000 | $1,945,723 | +$45,723 | +2.4% | 1,117 | $19,140,000 | $19,185,853 | 5 | Lionsgate Films | - |
| 12 | 12 | - | Ocean's Thirteen | $1,050,000 | $1,012,427 | -$37,573 | -3.6% | 750 | $114,570,000 | $114,533,366 | 7 | Warner Bros. | - |
| 13 | 13 | - | Fantastic Four: Rise of the Silver Surfer | $740,000 | $751,826 | +$11,826 | +1.6% | 601 | $128,868,000 | $128,879,368 | 6 | Twentieth Century Fox | - |
| 14 | 14 | - | Pirates of the Caribbean: At World's End | $730,000 | $730,059 | +$59 | <0.1% | 517 | $306,035,000 | $306,034,458 | 9 | Walt Disney Studios Motion Pictures | - |
| 15 | 16 | +1 | La Vie En Rose | $408,000 | $410,954 | +$2,954 | +0.7% | 178 | $7,596,000 | $7,598,240 | 7 | Picturehouse | - |
| 16 | 17 | +1 | Evening | $400,000 | - | - | - | 396 | $12,007,000 | - | 4 | Focus Features | - |
| 17 | 19 | +2 | Rescue Dawn | $354,000 | $349,842 | -$4,158 | -1.2% | 57 | $1,121,000 | $1,117,279 | 3 | Metro-Goldwyn-Mayer (MGM) | - |
| 18 | 20 | +2 | Talk to Me | $342,000 | - | - | - | 36 | $895,000 | - | 2 | Focus Features | - |
| 19 | 21 | +2 | Captivity | $340,000 | - | - | - | 754 | $2,465,000 | - | 2 | After Dark Films | - |
| 20 | 22 | +2 | You Kill Me | $321,000 | - | - | - | 252 | $2,079,000 | - | 5 | IFC Films | - |
| 21 | 24 | +3 | Once | $282,000 | $288,087 | +$6,087 | +2.2% | 112 | $5,535,000 | $5,541,181 | 10 | - | - |
| 22 | 25 | +3 | Sunshine | $235,000 | $242,964 | +$7,964 | +3.4% | 10 | $235,000 | $242,964 | 1 | - | - |
| 23 | 32 | +9 | Goya's Ghosts | $167,000 | $159,671 | -$7,329 | -4.4% | 49 | $167,000 | $159,671 | 1 | The Samuel Goldwyn Company | - |
| 24 | 31 | +7 | Waitress | $166,000 | $167,923 | +$1,923 | +1.2% | 165 | $18,222,000 | $18,223,592 | 12 | - | - |
| 25 | 34 | +9 | The Lives of Others | $154,000 | $153,721 | -$279 | -0.2% | 253 | $11,032,000 | $11,032,457 | 24 | Sony Pictures Classics | - |
| 26 | 39 | +13 | My Best Friend | $98,800 | $84,728 | -$14,072 | -14.2% | 13 | $167,000 | $152,858 | 2 | IFC Films | - |
| 27 | 38 | +11 | Paris, I Love You | $98,600 | $89,163 | -$9,437 | -9.6% | 64 | $4,618,000 | $4,608,310 | 12 | First Look International | - |
| 28 | 41 | +13 | Introducing the Dwights | $67,000 | $72,458 | +$5,458 | +8.1% | 70 | $258,000 | $263,040 | 3 | Warner Independent Pictures (WIP) | - |
| 29 | 44 | +15 | Interview | $49,000 | $55,612 | +$6,612 | +13.5% | 19 | $113,000 | $119,282 | 2 | Sony Pictures Classics | - |
| 30 | 47 | +17 | Joshua | $40,000 | $41,456 | +$1,456 | +3.6% | 47 | $441,000 | $442,201 | 3 | - | - |
| 31 | 52 | +21 | Hot Fuzz | $20,500 | $21,682 | +$1,182 | +5.8% | 51 | $23,618,000 | $23,618,786 | 14 | Rogue Pictures | - |
