| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | National Treasure: Book of Secrets | $20,225,000 | $20,062,684 | -$162,316 | -0.8% | 3,762 | $171,033,000 | $170,870,795 | 3 | Walt Disney Studios Motion Pictures | - |
| 2 | 3 | +1 | I Am Legend | $16,300,000 | $15,717,458 | -$582,542 | -3.6% | 3,648 | $228,638,000 | $228,055,662 | 4 | Warner Bros. | - |
| 3 | 2 | -1 | Juno | $16,225,000 | $15,860,744 | -$364,256 | -2.2% | 1,925 | $52,032,000 | $51,667,586 | 5 | - | - |
| 4 | 4 | - | Alvin and the Chipmunks | $16,000,000 | $15,546,125 | -$453,875 | -2.8% | 3,462 | $176,738,000 | $176,283,861 | 4 | Twentieth Century Fox | - |
| 5 | 5 | - | One Missed Call | $13,525,000 | $12,511,473 | -$1,013,527 | -7.5% | 2,240 | $13,525,000 | $12,511,473 | 1 | Warner Bros. | - |
| 6 | 6 | - | Charlie Wilson's War | $8,184,000 | $8,106,250 | -$77,750 | -1% | 2,594 | $52,630,000 | $52,552,540 | 3 | Universal Pictures | - |
| 7 | 7 | - | P.S. I Love You | $8,010,000 | $7,834,467 | -$175,533 | -2.2% | 2,471 | $39,378,000 | $39,202,724 | 3 | Warner Bros. | - |
| 8 | 8 | - | The Water Horse | $6,300,000 | $6,230,489 | -$69,511 | -1.1% | 2,777 | $30,893,000 | $30,823,470 | 2 | Revolution Studios | - |
| 9 | 9 | - | Sweeney Todd: The Demon Barber of Fleet Street | $5,400,000 | $5,536,538 | +$136,538 | +2.5% | 1,249 | $38,472,000 | $38,608,100 | 3 | DreamWorks | - |
| 10 | 10 | - | Atonement | $5,124,000 | $5,064,577 | -$59,423 | -1.2% | 583 | $19,216,000 | $19,155,607 | 5 | Focus Features | - |
| 11 | 11 | - | Aliens vs. Predator: Requiem | $4,250,000 | $4,484,155 | +$234,155 | +5.5% | 2,617 | $36,821,000 | $37,054,994 | 2 | Twentieth Century Fox | - |
| 12 | 12 | - | The Great Debaters | $4,245,000 | $4,250,948 | +$5,948 | +0.1% | 1,290 | $22,008,000 | $22,013,765 | 2 | - | - |
| 13 | 13 | - | Enchanted | $3,676,000 | $3,807,523 | +$131,523 | +3.6% | 1,932 | $119,689,000 | $119,820,940 | 7 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | The Golden Compass | $2,730,000 | - | - | - | 1,611 | $65,521,000 | - | 5 | New Line Cinema | - |
| 15 | 15 | - | No Country for Old Men | $1,843,000 | - | - | - | 819 | $44,785,000 | - | 9 | Miramax | - |
| 16 | 17 | +1 | The Kite Runner | $1,706,000 | $1,647,029 | -$58,971 | -3.5% | 380 | $8,728,000 | $8,669,803 | 4 | Paramount Vantage | - |
| 17 | 16 | -1 | Walk Hard: The Dewey Cox Story | $1,700,000 | $1,800,986 | +$100,986 | +5.9% | 2,041 | $17,183,000 | $17,284,363 | 3 | Sony Pictures Releasing | - |
| 18 | 18 | - | There Will Be Blood | $1,337,000 | $1,321,144 | -$15,856 | -1.2% | 51 | $1,845,000 | $1,829,285 | 2 | Paramount Vantage | - |
| 19 | 19 | - | The Orphanage | $501,000 | $500,671 | -$329 | <0.1% | 69 | $918,000 | $917,756 | 2 | Picturehouse | - |
| 20 | 20 | - | The Savages | $455,000 | $457,343 | +$2,343 | +0.5% | 110 | $2,553,000 | $2,545,266 | 6 | - | - |
| 21 | 22 | +1 | The Diving Bell and the Butterfly | $342,000 | $345,685 | +$3,685 | +1.1% | 57 | $1,455,000 | $1,458,913 | 6 | Miramax | - |
| 22 | 23 | +1 | The Bucket List | $315,000 | $326,786 | +$11,786 | +3.7% | 16 | $1,297,000 | $1,308,990 | 2 | Warner Bros. | - |
| 23 | 24 | +1 | American Gangster | $257,000 | $260,120 | +$3,120 | +1.2% | 327 | $129,496,000 | $129,499,865 | 10 | Universal Pictures | - |
| 24 | 33 | +9 | Before the Devil Knows You're Dead | $137,000 | $135,188 | -$1,812 | -1.3% | 92 | $6,655,000 | $6,652,931 | 11 | THINKFilm | - |
| 25 | 37 | +12 | I'm Not There | $103,000 | $108,525 | +$5,525 | +5.4% | 79 | $3,287,000 | $3,292,335 | 7 | The Weinstein Company | - |
| 26 | 40 | +14 | Persepolis | $80,000 | $76,867 | -$3,133 | -3.9% | 7 | $317,000 | $313,640 | 2 | Sony Pictures Classics | - |
| 27 | 45 | +18 | Awake | $43,000 | $38,916 | -$4,084 | -9.5% | 68 | $14,143,000 | $14,139,086 | 6 | - | - |
| 28 | 49 | +21 | Lars and the Real Girl | $41,000 | $36,886 | -$4,114 | -10% | 38 | $5,765,000 | $5,760,558 | 13 | Metro-Goldwyn-Mayer (MGM) | - |
| 29 | 52 | +23 | The Mist | $31,000 | $24,776 | -$6,224 | -20.1% | 61 | $25,342,000 | $25,335,717 | 7 | - | - |
| 30 | 55 | +25 | Lust, Caution | $20,200 | $19,873 | -$327 | -1.6% | 12 | $4,563,000 | $4,563,185 | 15 | Focus Features | - |
| 31 | 61 | +30 | Control | $4,760 | $6,657 | +$1,897 | +39.9% | 6 | $845,000 | $846,276 | 13 | The Weinstein Company | - |
| 32 | 68 | +36 | Lions for Lambs | $2,000 | $2,173 | +$173 | +8.6% | 7 | $14,938,000 | $14,938,321 | 9 | United Artists | - |
