| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Cloverfield | $41,000,000 | $40,058,229 | -$941,771 | -2.3% | 3,411 | $41,000,000 | $40,058,229 | 1 | Paramount Pictures | - |
| 2 | 2 | - | 27 Dresses | $22,427,000 | $23,007,725 | +$580,725 | +2.6% | 3,057 | $22,427,000 | $23,007,725 | 1 | Twentieth Century Fox | - |
| 3 | 3 | - | The Bucket List | $15,150,000 | $14,078,871 | -$1,071,129 | -7.1% | 2,915 | $42,709,000 | $41,638,304 | 4 | Warner Bros. | - |
| 4 | 4 | - | Juno | $10,250,000 | $9,954,874 | -$295,126 | -2.9% | 2,534 | $85,377,000 | $85,081,407 | 7 | - | - |
| 5 | 7 | +2 | National Treasure: Book of Secrets | $8,148,000 | $7,550,254 | -$597,746 | -7.3% | 2,963 | $198,030,000 | $197,433,099 | 5 | Walt Disney Studios Motion Pictures | - |
| 6 | 5 | -1 | First Sunday | $7,800,000 | $7,801,017 | +$1,017 | <0.1% | 2,213 | $28,466,000 | $28,466,619 | 2 | Screen Gems | - |
| 7 | 6 | -1 | Mad Money | $7,700,000 | $7,736,452 | +$36,452 | +0.5% | 2,470 | $7,700,000 | $7,736,453 | 1 | Overture Films | - |
| 8 | 8 | - | Alvin and the Chipmunks | $7,000,000 | $6,949,111 | -$50,889 | -0.7% | 2,962 | $196,380,000 | $196,329,292 | 6 | Twentieth Century Fox | - |
| 9 | 9 | - | I Am Legend | $5,105,000 | $4,891,373 | -$213,627 | -4.2% | 2,525 | $247,682,000 | $247,468,797 | 6 | Warner Bros. | - |
| 10 | 10 | - | Atonement | $4,759,000 | $4,596,844 | -$162,156 | -3.4% | 1,291 | $31,884,000 | $31,721,650 | 7 | Focus Features | - |
| 11 | 11 | - | There Will Be Blood | $3,121,000 | $2,941,582 | -$179,418 | -5.7% | 389 | $8,155,000 | $7,976,212 | 4 | Paramount Vantage | - |
| 12 | 12 | - | One Missed Call | $2,830,000 | $2,856,444 | +$26,444 | +0.9% | 1,925 | $24,431,000 | $24,457,206 | 3 | Warner Bros. | - |
| 13 | 14 | +1 | The Pirates Who Don't Do Anything | $2,814,000 | $2,606,175 | -$207,825 | -7.4% | 1,340 | $7,701,000 | $7,493,085 | 2 | Universal Pictures | - |
| 14 | 13 | -1 | Sweeney Todd: The Demon Barber of Fleet Street | $2,622,000 | $2,680,098 | +$58,098 | +2.2% | 1,507 | $48,047,000 | $48,104,898 | 5 | DreamWorks | - |
| 15 | 15 | - | Charlie Wilson's War | $2,204,000 | $1,967,160 | -$236,840 | -10.7% | 1,352 | $63,052,000 | $62,814,670 | 5 | Universal Pictures | - |
| 16 | 16 | - | P.S. I Love You | $1,905,000 | $1,963,423 | +$58,423 | +3.1% | 1,626 | $50,396,000 | $50,454,084 | 5 | Warner Bros. | - |
| 17 | 17 | - | The Water Horse | $1,800,000 | $1,784,413 | -$15,587 | -0.9% | 1,661 | $37,651,000 | $37,635,891 | 4 | Revolution Studios | - |
| 18 | 19 | +1 | The Great Debaters | $1,416,000 | $1,348,191 | -$67,809 | -4.8% | 1,021 | $27,855,000 | $27,787,656 | 4 | - | - |
| 19 | 18 | -1 | No Country for Old Men | $1,351,000 | - | - | - | 818 | $48,730,000 | - | 11 | Miramax | - |
| 20 | 21 | +1 | The Kite Runner | $1,127,000 | $1,102,367 | -$24,633 | -2.2% | 606 | $12,737,000 | $12,712,767 | 6 | Paramount Vantage | - |
| 21 | 20 | -1 | The Orphanage | $1,116,000 | $1,192,650 | +$76,650 | +6.9% | 702 | $4,947,000 | $5,023,368 | 4 | Picturehouse | - |
| 22 | 22 | - | Enchanted | $1,000,000 | $988,665 | -$11,335 | -1.1% | 767 | $123,789,000 | $123,783,407 | 9 | Walt Disney Studios Motion Pictures | - |
| 23 | 23 | - | In the Name of the King: A Dungeon Siege Tale | $735,000 | - | - | - | 1,338 | $4,314,000 | - | 2 | Freestyle Releasing | - |
| 24 | 27 | +3 | Cassandra's Dream | $501,000 | $361,901 | -$139,099 | -27.8% | 107 | $501,000 | $361,901 | 1 | The Weinstein Company | - |
| 25 | 24 | -1 | The Savages | $450,000 | $434,597 | -$15,403 | -3.4% | 175 | $3,567,000 | $3,551,650 | 8 | - | - |
| 26 | 25 | -1 | The Golden Compass | $425,000 | - | - | - | 340 | $68,243,000 | - | 7 | New Line Cinema | - |
| 27 | 26 | -1 | The Diving Bell and the Butterfly | $396,000 | - | - | - | 107 | $2,537,000 | - | 8 | Miramax | - |
| 28 | 30 | +2 | Persepolis | $281,000 | $242,840 | -$38,160 | -13.6% | 30 | $910,000 | $871,078 | 4 | Sony Pictures Classics | - |
| 29 | 36 | +7 | American Gangster | $132,000 | $123,450 | -$8,550 | -6.5% | 213 | $129,976,000 | $129,967,250 | 12 | Universal Pictures | - |
| 30 | 39 | +9 | I'm Not There | $73,000 | $57,852 | -$15,148 | -20.8% | 61 | $3,548,000 | $3,532,921 | 9 | The Weinstein Company | - |
| 31 | 40 | +9 | Before the Devil Knows You're Dead | $50,100 | $48,084 | -$2,016 | -4% | 58 | $6,901,000 | $6,898,847 | 13 | THINKFilm | - |
| 32 | 50 | +18 | Blonde and Blonder | $26,500 | $26,470 | -$30 | -0.1% | 14 | $26,500 | $26,470 | 1 | Hannover House | - |
| 33 | 53 | +20 | Lars and the Real Girl | $25,500 | $21,402 | -$4,098 | -16.1% | 35 | $5,841,000 | $5,837,126 | 15 | Metro-Goldwyn-Mayer (MGM) | - |
| 34 | 49 | +15 | Lions for Lambs | $25,000 | $26,883 | +$1,883 | +7.5% | 95 | $14,965,000 | $14,966,978 | 11 | United Artists | - |
| 35 | 56 | +21 | Nanking | $19,600 | $18,249 | -$1,351 | -6.9% | 4 | $76,200 | $74,808 | 6 | THINKFilm | - |
| 36 | 60 | +24 | The Mist | $14,300 | $16,360 | +$2,060 | +14.4% | 33 | $25,388,000 | $25,389,641 | 9 | - | - |
| 37 | 66 | +29 | Day Zero | $12,700 | $12,070 | -$630 | -5% | 2 | $12,700 | $12,070 | 1 | First Look International | - |
| 38 | 69 | +31 | Taxi to the Dark Side | $12,450 | $10,930 | -$1,520 | -12.2% | 2 | $12,450 | $10,930 | 1 | THINKFilm | - |
| 39 | 65 | +26 | Awake | $11,600 | $12,717 | +$1,117 | +9.6% | 23 | $14,206,000 | $14,207,296 | 8 | - | - |
| 40 | 72 | +32 | Lust, Caution | $10,800 | $7,926 | -$2,874 | -26.6% | 8 | $4,603,000 | $4,600,579 | 17 | Focus Features | - |
