| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Twilight | $70,553,000 | $69,637,740 | -$915,260 | -1.3% | 3,419 | $70,553,000 | $69,637,740 | 1 | Summit Entertainment | - |
| 2 | 2 | - | Quantum of Solace | $27,400,000 | $26,707,945 | -$692,055 | -2.5% | 3,458 | $109,483,000 | $108,790,786 | 2 | Sony Pictures Releasing | - |
| 3 | 3 | - | Bolt | $27,000,000 | $26,223,128 | -$776,872 | -2.9% | 3,651 | $27,000,000 | $26,223,128 | 1 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Madagascar: Escape 2 Africa | $16,000,000 | $15,661,936 | -$338,064 | -2.1% | 4,007 | $137,447,000 | $137,109,390 | 3 | DreamWorks | - |
| 5 | 5 | - | Role Models | $7,229,000 | $7,324,445 | +$95,445 | +1.3% | 2,733 | $48,037,000 | $48,133,020 | 3 | Universal Pictures | - |
| 6 | 6 | - | Changeling | $2,643,000 | $2,695,450 | +$52,450 | +2% | 1,739 | $31,613,000 | $31,665,332 | 5 | Universal Pictures | - |
| 7 | 7 | - | High School Musical 3: Senior Year | $2,006,000 | $2,049,144 | +$43,144 | +2.2% | 2,361 | $86,821,000 | $86,864,082 | 5 | Walt Disney Studios Motion Pictures | - |
| 8 | 9 | +1 | Zack and Miri Make a Porno | $1,700,000 | $1,605,579 | -$94,421 | -5.6% | 1,222 | $29,350,000 | $29,256,029 | 4 | The Weinstein Company | - |
| 9 | 8 | -1 | The Boy in the Striped Pajamas | $1,673,000 | $1,647,514 | -$25,486 | -1.5% | 406 | $2,653,000 | $2,628,053 | 3 | Miramax | - |
| 10 | 10 | - | The Secret Life of Bees | $1,275,000 | $1,264,991 | -$10,009 | -0.8% | 1,095 | $35,649,000 | $35,638,795 | 6 | - | - |
| 11 | 11 | - | Slumdog Millionaire | $994,000 | $947,795 | -$46,205 | -4.6% | 32 | $1,616,000 | $1,570,240 | 2 | - | - |
| 12 | 12 | - | Soul Men | $930,000 | $912,269 | -$17,731 | -1.9% | 814 | $10,918,000 | $10,900,509 | 3 | - | - |
| 13 | 13 | - | Fireproof | $900,000 | $909,404 | +$9,404 | +1% | 823 | $31,505,000 | $31,514,538 | 9 | The Samuel Goldwyn Company | - |
| 14 | 14 | - | Rachel Getting Married | $765,000 | $751,611 | -$13,389 | -1.8% | 300 | $8,016,000 | $8,003,380 | 8 | Sony Pictures Classics | - |
| 15 | 15 | - | Eagle Eye | $680,000 | $667,605 | -$12,395 | -1.8% | 757 | $99,753,000 | $99,740,445 | 9 | DreamWorks | - |
| 16 | 17 | +1 | Saw V | $480,000 | $459,081 | -$20,919 | -4.4% | 694 | $56,405,000 | $56,383,962 | 5 | Lionsgate Films | - |
| 17 | 18 | +1 | The Haunting of Molly Hartley | $470,000 | $385,013 | -$84,987 | -18.1% | 614 | $13,266,000 | $13,180,859 | 4 | Freestyle Releasing | - |
| 18 | 16 | -2 | Beverly Hills Chihuahua | $450,000 | $468,078 | +$18,078 | +4% | 788 | $91,600,000 | $91,614,153 | 8 | Walt Disney Studios Motion Pictures | - |
| 19 | 20 | +1 | Happy-Go-Lucky | $358,000 | $338,071 | -$19,929 | -5.6% | 202 | $2,233,000 | $2,213,147 | 7 | Miramax | - |
| 20 | 21 | +1 | Synecdoche, New York | $343,000 | $319,110 | -$23,890 | -7% | 111 | $1,578,000 | $1,554,060 | 5 | Sony Pictures Classics | - |
| 21 | 25 | +4 | I've Loved You So Long | $185,000 | $194,337 | +$9,337 | +5% | 37 | $1,237,000 | $1,245,904 | 5 | Sony Pictures Classics | - |
| 22 | 27 | +5 | A Christmas Tale | $160,000 | $162,689 | +$2,689 | +1.7% | 36 | $254,000 | $256,151 | 2 | IFC Films | - |
| 23 | 28 | +5 | Max Payne | $143,000 | $150,463 | +$7,463 | +5.2% | 264 | $40,293,000 | $40,300,771 | 6 | Twentieth Century Fox | - |
| 24 | 30 | +6 | W. | $140,000 | $131,523 | -$8,477 | -6.1% | 191 | $25,420,000 | $25,411,191 | 6 | Lionsgate Films | - |
| 25 | 33 | +8 | The Duchess | $120,000 | $117,896 | -$2,104 | -1.8% | 154 | $13,672,000 | $13,670,183 | 10 | Paramount Vantage | - |
| 26 | 31 | +5 | Religulous | $110,000 | $123,599 | +$13,599 | +12.4% | 140 | $12,759,000 | $12,772,716 | 8 | Lionsgate Films | - |
| 27 | 40 | +13 | JCVD | $63,500 | $61,242 | -$2,258 | -3.6% | 26 | $199,000 | $197,072 | 3 | - | - |
| 28 | 45 | +17 | Igor | $42,000 | $41,327 | -$673 | -1.6% | 52 | $19,099,000 | $19,098,493 | 10 | Metro-Goldwyn-Mayer (MGM) | - |
| 29 | 43 | +14 | Vicky Cristina Barcelona | $40,000 | $43,433 | +$3,433 | +8.6% | 35 | $22,414,000 | $22,417,130 | 15 | - | - |
| 30 | 51 | +21 | My Name Is Bruce | $24,700 | $22,598 | -$2,102 | -8.5% | 4 | $108,000 | $105,245 | 4 | Image Entertainment | - |
| 31 | 54 | +23 | Noah's Arc: Jumping the Broom | $17,800 | $18,729 | +$929 | +5.2% | 5 | $482,000 | $482,638 | 5 | - | - |
| 32 | 61 | +29 | The Longshots | $13,000 | $13,215 | +$215 | +1.7% | 32 | $11,508,000 | $11,508,423 | 14 | - | - |
| 33 | 69 | +36 | Repo! The Genetic Opera | $8,370 | $8,057 | -$313 | -3.7% | 6 | $108,000 | $108,045 | 3 | Lionsgate Films | - |
| 34 | 83 | +49 | Eden | $2,790 | $2,729 | -$61 | -2.2% | 2 | $7,530 | $7,473 | 2 | Liberation Entertainment | - |
| 35 | 85 | +50 | The First Basket | $2,220 | $2,471 | +$251 | +11.3% | 3 | $16,100 | $16,552 | 4 | - | - |
| 36 | 94 | +58 | Hounddog | $1,675 | $1,675 | $0 | - | 1 | $118,879 | $118,879 | 10 | Empire Pictures Inc. | - |
| 37 | 96 | +59 | The Other End of the Line | $1,600 | $1,515 | -$85 | -5.3% | 3 | $114,000 | $113,913 | 4 | Metro-Goldwyn-Mayer (MGM) | - |
| 38 | 106 | +68 | How to Lose Friends & Alienate People | $650 | $772 | +$122 | +18.8% | 4 | $2,760,000 | $2,760,453 | 8 | Metro-Goldwyn-Mayer (MGM) | - |
