| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Yes Man | $18,160,000 | $18,262,471 | +$102,471 | +0.6% | 3,434 | $18,160,000 | $18,262,471 | 1 | Warner Bros. | - |
| 2 | 2 | - | Seven Pounds | $16,000,000 | $14,851,136 | -$1,148,864 | -7.2% | 2,758 | $16,000,000 | $14,851,136 | 1 | Sony Pictures Releasing | - |
| 3 | 3 | - | The Tale of Despereaux | $10,507,000 | $10,103,675 | -$403,325 | -3.8% | 3,104 | $10,507,000 | $10,103,675 | 1 | Universal Pictures | - |
| 4 | 4 | - | The Day the Earth Stood Still | $10,150,000 | $9,890,105 | -$259,895 | -2.6% | 3,560 | $48,627,000 | $48,366,989 | 2 | Twentieth Century Fox | - |
| 5 | 5 | - | Four Christmases | $7,745,000 | $7,701,375 | -$43,625 | -0.6% | 3,515 | $100,154,000 | $100,110,827 | 4 | Warner Bros. | - |
| 6 | 6 | - | Twilight | $5,227,000 | $5,189,319 | -$37,681 | -0.7% | 2,991 | $158,461,000 | $158,423,218 | 5 | Summit Entertainment | - |
| 7 | 7 | - | Bolt | $4,256,000 | $4,146,856 | -$109,144 | -2.6% | 2,968 | $95,009,000 | $94,900,059 | 5 | Walt Disney Studios Motion Pictures | - |
| 8 | 8 | - | Slumdog Millionaire | $3,150,000 | $3,053,760 | -$96,240 | -3.1% | 589 | $12,134,000 | $12,037,510 | 6 | - | - |
| 9 | 9 | - | Australia | $2,325,000 | $2,174,188 | -$150,812 | -6.5% | 2,212 | $41,947,000 | $41,796,525 | 4 | Twentieth Century Fox | - |
| 10 | 10 | - | Quantum of Solace | $2,150,000 | $2,051,882 | -$98,118 | -4.6% | 1,874 | $161,300,000 | $161,200,412 | 6 | Sony Pictures Releasing | - |
| 11 | 11 | - | Milk | $1,641,000 | $1,729,156 | +$88,156 | +5.4% | 356 | $10,322,000 | $10,410,039 | 4 | Focus Features | - |
| 12 | 12 | - | Madagascar: Escape 2 Africa | $1,510,000 | $1,569,610 | +$59,610 | +3.9% | 2,007 | $172,332,000 | $172,392,069 | 7 | DreamWorks | - |
| 13 | 13 | - | Nothing Like the Holidays | $1,319,000 | $1,305,439 | -$13,561 | -1% | 1,671 | $5,940,000 | $5,924,513 | 2 | Overture Films | - |
| 14 | 15 | +1 | Doubt | $729,000 | $680,948 | -$48,052 | -6.6% | 39 | $1,448,000 | $1,399,548 | 2 | Miramax | - |
| 15 | 14 | -1 | Transporter 3 | $650,000 | $682,033 | +$32,033 | +4.9% | 1,007 | $31,037,000 | $31,069,389 | 4 | Lionsgate Films | - |
| 16 | 17 | +1 | Cadillac Records | $650,000 | $606,748 | -$43,252 | -6.7% | 701 | $7,090,000 | $7,046,250 | 3 | Sony Pictures Releasing | - |
| 17 | 16 | -1 | Role Models | $584,000 | $645,395 | +$61,395 | +10.5% | 792 | $65,532,000 | $65,593,985 | 7 | Universal Pictures | - |
| 18 | 18 | - | Gran Torino | $468,000 | $468,221 | +$221 | <0.1% | 19 | $859,000 | $859,860 | 2 | Warner Bros. | - |
| 19 | 19 | - | Frost/Nixon | $365,000 | $378,052 | +$13,052 | +3.6% | 39 | $1,478,000 | $1,491,262 | 3 | Universal Pictures | - |
| 20 | 21 | +1 | The Boy in the Striped Pajamas | $285,000 | $274,481 | -$10,519 | -3.7% | 403 | $8,390,000 | $8,379,440 | 7 | Miramax | - |
| 21 | 24 | +3 | The Wrestler | $209,000 | $202,714 | -$6,286 | -3% | 4 | $295,000 | $288,220 | 1 | - | - |
| 22 | 25 | +3 | Punisher: War Zone | $170,000 | $193,995 | +$23,995 | +14.1% | 385 | $7,924,000 | $7,948,159 | 3 | Lionsgate Films | - |
| 23 | 26 | +3 | Rachel Getting Married | $135,000 | $130,230 | -$4,770 | -3.5% | 115 | $9,790,000 | $9,785,033 | 12 | Sony Pictures Classics | - |
| 24 | 27 | +3 | Eagle Eye | $122,000 | $129,410 | +$7,410 | +6.1% | 254 | $100,849,000 | $100,856,790 | 13 | DreamWorks | - |
| 25 | 28 | +3 | Changeling | $102,000 | $101,905 | -$95 | <0.1% | 229 | $35,397,000 | $35,397,257 | 9 | Universal Pictures | - |
| 26 | 29 | +3 | The Reader | $100,000 | $92,790 | -$7,210 | -7.2% | 8 | $357,000 | $349,240 | 2 | The Weinstein Company | - |
| 27 | 30 | +3 | I've Loved You So Long | $78,500 | $83,284 | +$4,784 | +6.1% | 52 | $2,048,000 | $2,052,667 | 9 | Sony Pictures Classics | - |
| 28 | 31 | +3 | Vicky Cristina Barcelona | $71,000 | $72,723 | +$1,723 | +2.4% | 162 | $22,657,000 | $22,658,945 | 19 | - | - |
| 29 | 36 | +7 | Synecdoche, New York | $59,500 | $53,622 | -$5,878 | -9.9% | 56 | $2,545,000 | $2,547,673 | 9 | Sony Pictures Classics | - |
| 30 | 40 | +10 | Happy-Go-Lucky | $48,000 | $44,621 | -$3,379 | -7% | 84 | $3,105,000 | $3,101,671 | 11 | Miramax | - |
| 31 | 42 | +11 | Zack and Miri Make a Porno | $32,000 | $36,307 | +$4,307 | +13.5% | 87 | $31,149,000 | $31,153,007 | 8 | The Weinstein Company | - |
| 32 | 48 | +16 | Igor | $19,000 | $18,382 | -$618 | -3.3% | 82 | $19,421,000 | $19,420,496 | 14 | Metro-Goldwyn-Mayer (MGM) | - |
| 33 | 51 | +18 | Wendy and Lucy | $16,300 | $16,004 | -$296 | -1.8% | 6 | $50,900 | $50,650 | 2 | Oscilloscope | - |
| 34 | 52 | +18 | Soul Men | $15,000 | $14,756 | -$244 | -1.6% | 95 | $11,998,000 | $11,998,223 | 7 | - | - |
