| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Brüno | $30,426,000 | $30,619,130 | +$193,130 | +0.6% | 2,756 | $30,426,000 | $30,619,130 | 1 | Universal Pictures | - |
| 2 | 2 | - | Ice Age: Dawn of the Dinosaurs | $28,500,000 | $27,607,497 | -$892,503 | -3.1% | 4,102 | $120,573,000 | $119,680,193 | 2 | Twentieth Century Fox | - |
| 3 | 3 | - | Transformers: Revenge of the Fallen | $24,200,000 | $24,213,875 | +$13,875 | <0.1% | 4,293 | $339,208,000 | $339,221,800 | 3 | DreamWorks | - |
| 4 | 4 | - | Public Enemies | $14,111,000 | $13,794,240 | -$316,760 | -2.2% | 3,336 | $66,538,000 | $66,221,110 | 2 | Universal Pictures | - |
| 5 | 5 | - | The Proposal | $10,507,000 | $10,603,884 | +$96,884 | +0.9% | 3,158 | $113,764,000 | $113,861,076 | 4 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | The Hangover | $9,930,000 | $9,933,238 | +$3,238 | <0.1% | 3,002 | $222,442,000 | $222,444,906 | 6 | Warner Bros. | - |
| 7 | 7 | - | I Love You, Beth Cooper | $5,000,000 | $4,919,433 | -$80,567 | -1.6% | 1,858 | $5,000,000 | $4,919,433 | 1 | Twentieth Century Fox | - |
| 8 | 8 | - | Up | $4,656,000 | $4,715,746 | +$59,746 | +1.3% | 2,201 | $273,775,000 | $273,834,761 | 7 | Walt Disney Studios Motion Pictures | - |
| 9 | 9 | - | My Sister's Keeper | $4,180,000 | $4,294,382 | +$114,382 | +2.7% | 2,444 | $35,801,000 | $35,915,782 | 3 | Warner Bros. | - |
| 10 | 10 | - | The Taking of Pelham 123 | $1,600,000 | $1,543,516 | -$56,484 | -3.5% | 1,116 | $61,494,000 | $61,437,955 | 5 | Sony Pictures Releasing | - |
| 11 | 11 | - | Night at the Museum: Battle of the Smithsonian | $1,525,000 | $1,452,662 | -$72,338 | -4.7% | 854 | $170,558,000 | $170,485,184 | 8 | Twentieth Century Fox | - |
| 12 | 12 | - | Star Trek | $1,130,000 | $1,164,416 | +$34,416 | +3% | 763 | $251,936,000 | $251,970,795 | 10 | Paramount Pictures | - |
| 13 | 13 | - | Year One | $1,000,000 | $1,000,581 | +$581 | <0.1% | 990 | $41,192,000 | $41,192,481 | 4 | Sony Pictures Releasing | - |
| 14 | 14 | - | Away We Go | $749,000 | $728,773 | -$20,227 | -2.7% | 406 | $7,440,000 | $7,420,575 | 6 | Focus Features | - |
| 15 | 15 | - | Whatever Works | $740,000 | $678,055 | -$61,945 | -8.4% | 320 | $3,161,000 | $3,099,917 | 4 | Sony Pictures Classics | - |
| 16 | 16 | - | Moon | $721,000 | $674,900 | -$46,100 | -6.4% | 247 | $1,832,000 | $1,785,478 | 5 | Sony Pictures Classics | - |
| 17 | 17 | - | The Hurt Locker | $623,000 | $641,168 | +$18,168 | +2.9% | 60 | $1,084,000 | $1,101,834 | 3 | Summit Entertainment | - |
| 18 | 18 | - | Land of the Lost | $365,000 | $352,125 | -$12,875 | -3.5% | 313 | $48,197,000 | $48,184,350 | 6 | Universal Pictures | - |
| 19 | 19 | - | Chéri | $361,000 | $344,027 | -$16,973 | -4.7% | 173 | $1,586,000 | $1,568,767 | 3 | Miramax | - |
| 20 | 25 | +5 | Monsters vs. Aliens | $250,000 | $250,308 | +$308 | +0.1% | 261 | $197,116,000 | $197,116,821 | 16 | DreamWorks | - |
| 21 | 24 | +3 | Food, Inc. | $250,000 | $251,114 | +$1,114 | +0.4% | 81 | $1,707,000 | $1,708,941 | 5 | Magnolia Pictures | - |
| 22 | 27 | +5 | Drag Me to Hell | $198,000 | $220,515 | +$22,515 | +11.4% | 241 | $41,426,000 | $41,449,165 | 7 | Universal Pictures | - |
| 23 | 29 | +6 | Imagine That | $181,000 | $171,809 | -$9,191 | -5.1% | 209 | $15,129,000 | $15,120,353 | 5 | Paramount Pictures | - |
| 24 | 30 | +6 | Dance Flick | $135,000 | $140,310 | +$5,310 | +3.9% | 165 | $25,450,000 | $25,454,737 | 8 | Paramount Pictures | - |
| 25 | 32 | +7 | Blood: The Last Vampire | $103,000 | $110,029 | +$7,029 | +6.8% | 20 | $103,000 | $110,029 | 1 | The Samuel Goldwyn Company | - |
| 26 | 38 | +12 | Easy Virtue | $67,300 | $58,630 | -$8,670 | -12.9% | 48 | $2,402,000 | $2,393,438 | 8 | Sony Pictures Classics | - |
| 27 | 41 | +14 | The Stoning of Soraya M. | $52,500 | $52,166 | -$334 | -0.6% | 25 | $339,000 | $338,692 | 3 | Roadside Attractions | - |
| 28 | 43 | +15 | The Brothers Bloom | $47,000 | $45,268 | -$1,732 | -3.7% | 90 | $3,368,000 | $3,366,558 | 9 | Summit Entertainment | - |
| 29 | 46 | +17 | Every Little Step | $29,800 | $26,973 | -$2,827 | -9.5% | 33 | $1,531,000 | $1,528,106 | 13 | Sony Pictures Classics | - |
| 30 | 45 | +15 | Humpday | $29,000 | $28,737 | -$263 | -0.9% | 2 | $29,000 | $28,737 | 1 | Magnolia Pictures | - |
| 31 | 48 | +17 | Soul Power | $25,100 | $23,893 | -$1,207 | -4.8% | 6 | $25,100 | $23,893 | 1 | Sony Pictures Classics | - |
| 32 | 51 | +19 | Tetro | $20,300 | $21,502 | +$1,202 | +5.9% | 10 | $272,000 | $273,192 | 5 | American Zoetrope | - |
| 33 | 56 | +23 | Unmistaken Child | $12,300 | $12,634 | +$334 | +2.7% | 5 | $109,000 | $109,160 | 6 | Oscilloscope | - |
