| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | District 9 | $37,000,000 | $37,354,308 | +$354,308 | +1% | 3,049 | $37,000,000 | $37,354,308 | 1 | TriStar Pictures | - |
| 2 | 2 | - | G.I. Joe: The Rise of Cobra | $22,500,000 | $22,324,341 | -$175,659 | -0.8% | 4,007 | $98,753,000 | $98,577,529 | 2 | Paramount Pictures | - |
| 3 | 3 | - | The Time Traveler's Wife | $19,205,000 | $18,623,171 | -$581,829 | -3% | 2,988 | $19,205,000 | $18,623,171 | 1 | Warner Bros. | - |
| 4 | 4 | - | Julie & Julia | $12,400,000 | $12,055,918 | -$344,082 | -2.8% | 2,354 | $43,684,000 | $43,340,386 | 2 | Sony Pictures Releasing | - |
| 5 | 5 | - | G-Force | $6,908,000 | $6,915,642 | +$7,642 | +0.1% | 3,065 | $99,049,000 | $99,056,616 | 4 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | The Goods: Live Hard, Sell Hard | $5,350,000 | $5,642,137 | +$292,137 | +5.5% | 1,838 | $5,350,000 | $5,642,137 | 1 | Paramount Vantage | - |
| 7 | 7 | - | Harry Potter and the Half-Blood Prince | $5,155,000 | $5,141,072 | -$13,928 | -0.3% | 2,771 | $283,893,000 | $283,879,025 | 5 | Warner Bros. | - |
| 8 | 8 | - | The Ugly Truth | $4,500,000 | $4,448,232 | -$51,768 | -1.2% | 2,733 | $77,502,000 | $77,450,118 | 4 | Sony Pictures Releasing | - |
| 9 | 9 | - | Ponyo | $3,506,000 | $3,585,852 | +$79,852 | +2.3% | 927 | $3,506,000 | $3,585,852 | 1 | Walt Disney Studios Motion Pictures | - |
| 10 | 11 | +1 | 500 Days of Summer | $3,025,000 | $2,967,462 | -$57,538 | -1.9% | 1,048 | $17,955,000 | $17,897,509 | 5 | - | - |
| 11 | 10 | -1 | Funny People | $3,023,000 | $3,010,755 | -$12,245 | -0.4% | 2,584 | $47,923,000 | $47,910,620 | 3 | Universal Pictures | - |
| 12 | 12 | - | A Perfect Getaway | $2,796,000 | $2,860,100 | +$64,100 | +2.3% | 2,159 | $11,496,000 | $11,560,335 | 2 | Universal Pictures | - |
| 13 | 13 | - | Bandslam | $2,250,000 | $2,231,273 | -$18,727 | -0.8% | 2,121 | $2,250,000 | $2,231,273 | 1 | Summit Entertainment | - |
| 14 | 14 | - | The Hangover | $2,080,000 | $1,988,986 | -$91,014 | -4.4% | 1,185 | $265,881,000 | $265,790,452 | 11 | Warner Bros. | - |
| 15 | 16 | +1 | Orphan | $1,655,000 | $1,577,433 | -$77,567 | -4.7% | 1,261 | $38,424,000 | $38,346,772 | 4 | Warner Bros. | - |
| 16 | 15 | -1 | Transformers: Revenge of the Fallen | $1,600,000 | $1,604,523 | +$4,523 | +0.3% | 1,007 | $396,754,000 | $396,758,605 | 8 | DreamWorks | - |
| 17 | 17 | - | Aliens in the Attic | $1,450,000 | $1,449,859 | -$141 | <0.1% | 1,535 | $20,569,000 | $20,568,729 | 3 | Twentieth Century Fox | - |
| 18 | 18 | - | The Proposal | $1,297,000 | $1,301,551 | +$4,551 | +0.4% | 1,084 | $157,688,000 | $157,693,055 | 9 | Walt Disney Studios Motion Pictures | - |
| 19 | 19 | - | Ice Age: Dawn of the Dinosaurs | $1,280,000 | $1,268,700 | -$11,300 | -0.9% | 858 | $190,867,000 | $190,855,447 | 7 | Twentieth Century Fox | - |
| 20 | 21 | +1 | The Hurt Locker | $675,000 | $644,194 | -$30,806 | -4.6% | 478 | $10,397,000 | $10,365,831 | 8 | Summit Entertainment | - |
| 21 | 24 | +3 | Public Enemies | $371,000 | $359,675 | -$11,325 | -3.1% | 367 | $96,356,000 | $96,344,690 | 7 | Universal Pictures | - |
| 22 | 23 | +1 | Night at the Museum: Battle of the Smithsonian | $355,000 | $366,271 | +$11,271 | +3.2% | 278 | $175,527,000 | $175,538,731 | 13 | Twentieth Century Fox | - |
| 23 | 25 | +2 | Star Trek | $311,000 | $323,830 | +$12,830 | +4.1% | 303 | $255,924,000 | $255,936,227 | 15 | Paramount Pictures | - |
| 24 | 27 | +3 | The Collector | $237,000 | $228,118 | -$8,882 | -3.7% | 262 | $7,289,000 | $7,280,075 | 3 | Freestyle Releasing | - |
| 25 | 29 | +4 | Adam | $214,000 | $202,172 | -$11,828 | -5.5% | 66 | $525,000 | $513,453 | 3 | - | - |
| 26 | 30 | +4 | Paper Heart | $166,000 | $171,528 | +$5,528 | +3.3% | 68 | $512,000 | $517,414 | 2 | Overture Films | - |
| 27 | 34 | +7 | Spread | $117,000 | $122,948 | +$5,948 | +5.1% | 103 | $117,000 | $122,948 | 1 | Anchor Bay Films | - |
| 28 | 38 | +10 | Moon | $101,000 | $92,126 | -$8,874 | -8.8% | 100 | $4,463,000 | $4,453,944 | 10 | Sony Pictures Classics | - |
| 29 | 37 | +8 | It Might Get Loud | $101,000 | $92,679 | -$8,321 | -8.2% | 7 | $101,000 | $92,679 | 1 | Sony Pictures Classics | - |
| 30 | 41 | +11 | Brüno | $89,000 | $83,780 | -$5,220 | -5.9% | 142 | $59,998,000 | $59,992,760 | 6 | Universal Pictures | - |
| 31 | 39 | +8 | The Cove | $86,300 | $87,633 | +$1,333 | +1.5% | 53 | $424,000 | $424,893 | 3 | Roadside Attractions | - |
| 32 | 43 | +11 | Cold Souls | $71,400 | $70,626 | -$774 | -1.1% | 21 | $168,000 | $167,173 | 2 | The Samuel Goldwyn Company | - |
| 33 | 44 | +11 | Imagine That | $58,000 | $60,457 | +$2,457 | +4.2% | 107 | $16,086,000 | $16,088,610 | 10 | Paramount Pictures | - |
| 34 | 46 | +12 | Whatever Works | $56,800 | $51,611 | -$5,189 | -9.1% | 56 | $5,123,000 | $5,117,349 | 9 | Sony Pictures Classics | - |
| 35 | 45 | +10 | Monsters vs. Aliens | $52,000 | $55,318 | +$3,318 | +6.4% | 116 | $198,252,000 | $198,255,437 | 21 | DreamWorks | - |
| 36 | 47 | +11 | Thirst | $50,400 | $50,725 | +$325 | +0.6% | 15 | $228,000 | $227,873 | 3 | Focus Features | - |
| 37 | 55 | +18 | Lorna's Silence | $32,100 | $28,027 | -$4,073 | -12.7% | 16 | $121,000 | $117,294 | 3 | Sony Pictures Classics | - |
| 38 | 56 | +18 | Away We Go | $26,000 | $27,357 | +$1,357 | +5.2% | 54 | $9,430,000 | $9,430,988 | 11 | Focus Features | - |
| 39 | 60 | +21 | Chéri | $17,000 | $16,789 | -$211 | -1.2% | 30 | $2,684,000 | $2,684,051 | 8 | Miramax | - |
| 40 | 62 | +22 | Tetro | $15,200 | $16,049 | +$849 | +5.6% | 10 | $416,000 | $416,591 | 10 | American Zoetrope | - |
| 41 | 64 | +23 | War Eagle, Arkansas | $10,100 | $10,088 | -$12 | -0.1% | 3 | $120,000 | $120,177 | 10 | Hannover House | - |
| 42 | 67 | +25 | Shrink | $8,400 | $7,851 | -$549 | -6.5% | 7 | $166,000 | $165,214 | 4 | Roadside Attractions | - |
