| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Avatar | $41,300,000 | $42,785,612 | +$1,485,612 | +3.6% | 3,285 | $491,767,000 | $493,252,617 | 5 | Twentieth Century Fox | - |
| 2 | 2 | - | The Book of Eli | $31,615,000 | $32,789,494 | +$1,174,494 | +3.7% | 3,111 | $31,615,000 | $32,789,494 | 1 | Warner Bros. | - |
| 3 | 3 | - | The Lovely Bones | $17,060,000 | $17,005,133 | -$54,867 | -0.3% | 2,563 | $17,527,000 | $17,471,796 | 6 | DreamWorks | - |
| 4 | 4 | - | Alvin and the Chipmunks: The Squeakquel | $11,500,000 | $11,619,949 | +$119,949 | +1% | 3,296 | $192,592,000 | $192,711,792 | 4 | Twentieth Century Fox | - |
| 5 | 5 | - | Sherlock Holmes | $9,825,000 | $9,889,154 | +$64,154 | +0.7% | 3,173 | $180,018,000 | $180,082,554 | 4 | Warner Bros. | - |
| 6 | 6 | - | The Spy Next Door | $9,700,000 | $9,726,056 | +$26,056 | +0.3% | 2,924 | $9,700,000 | $9,726,056 | 1 | Lionsgate Films | - |
| 7 | 7 | - | It's Complicated | $7,672,000 | $8,112,555 | +$440,555 | +5.7% | 2,670 | $88,224,000 | $88,664,380 | 4 | Universal Pictures | - |
| 8 | 8 | - | Leap Year | $5,828,000 | $5,928,510 | +$100,510 | +1.7% | 2,512 | $17,529,000 | $17,629,680 | 2 | Universal Pictures | - |
| 9 | 9 | - | The Blind Side | $5,565,000 | $5,557,274 | -$7,726 | -0.1% | 2,408 | $226,774,000 | $226,766,539 | 9 | Warner Bros. | - |
| 10 | 10 | - | Up in the Air | $5,460,000 | $5,445,379 | -$14,621 | -0.3% | 2,107 | $62,833,000 | $62,818,397 | 7 | Paramount Pictures | - |
| 11 | 11 | - | Daybreakers | $5,000,000 | $5,185,554 | +$185,554 | +3.7% | 2,523 | $24,188,000 | $24,373,955 | 2 | Lionsgate Films | - |
| 12 | 12 | - | Youth in Revolt | $2,822,000 | $3,004,123 | +$182,123 | +6.5% | 1,873 | $11,961,000 | $12,143,155 | 2 | - | - |
| 13 | 13 | - | The Princess and the Frog | $2,732,000 | $2,777,707 | +$45,707 | +1.7% | 1,777 | $96,261,000 | $96,307,038 | 8 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | The Imaginarium of Doctor Parnassus | $1,067,000 | $1,073,303 | +$6,303 | +0.6% | 599 | $4,819,000 | $4,825,194 | 4 | Sony Pictures Classics | - |
| 15 | 15 | - | The Young Victoria | $955,000 | $950,411 | -$4,589 | -0.5% | 418 | $5,507,000 | $6,105,172 | 5 | Apparition | - |
| 16 | 16 | - | The Twilight Saga: New Moon | $914,000 | $928,939 | +$14,939 | +1.6% | 724 | $292,214,000 | $292,229,350 | 9 | Summit Entertainment | - |
| 17 | 17 | - | A Single Man | $824,000 | $843,600 | +$19,600 | +2.4% | 219 | $3,270,000 | $3,290,100 | 6 | The Weinstein Company | - |
| 18 | 18 | - | Invictus | $790,000 | $801,341 | +$11,341 | +1.4% | 602 | $34,959,000 | $34,970,393 | 6 | Warner Bros. | - |
| 19 | 19 | - | Crazy Heart | $658,000 | $647,473 | -$10,527 | -1.6% | 47 | $2,086,000 | $2,075,069 | 5 | - | - |
| 20 | 20 | - | Nine | $572,000 | $581,564 | +$9,564 | +1.7% | 422 | $18,139,000 | $18,148,467 | 5 | The Weinstein Company | - |
| 21 | 22 | +1 | Broken Embraces | $428,000 | $414,897 | -$13,103 | -3.1% | 202 | $3,131,000 | $3,117,207 | 9 | Sony Pictures Classics | - |
| 22 | 23 | +1 | Did You Hear About the Morgans? | $400,000 | $394,619 | -$5,381 | -1.3% | 521 | $29,290,000 | $29,284,626 | 5 | Sony Pictures Releasing | - |
| 23 | 26 | +3 | Precious | $230,000 | $238,797 | +$8,797 | +3.8% | 228 | $44,750,000 | $44,758,541 | 11 | Lionsgate Films | - |
| 24 | 29 | +5 | An Education | $168,000 | $147,510 | -$20,490 | -12.2% | 73 | $8,407,000 | $8,387,048 | 15 | Sony Pictures Classics | - |
| 25 | 30 | +5 | Brothers | $130,000 | $127,485 | -$2,515 | -1.9% | 174 | $28,479,000 | $28,476,783 | 7 | Lionsgate Films | - |
| 26 | 31 | +5 | Couples Retreat | $121,000 | $126,750 | +$5,750 | +4.8% | 169 | $108,906,000 | $108,911,575 | 15 | Universal Pictures | - |
| 27 | 34 | +7 | The Road | $115,000 | $124,062 | +$9,062 | +7.9% | 145 | $7,609,000 | $7,617,312 | 8 | - | - |
| 28 | 40 | +12 | The Last Station | $81,700 | $73,723 | -$7,977 | -9.8% | 3 | $114,000 | $73,723 | 1 | Sony Pictures Classics | - |
| 29 | 39 | +10 | The White Ribbon | $81,600 | $77,945 | -$3,655 | -4.5% | 12 | $277,000 | $273,065 | 3 | Sony Pictures Classics | - |
| 30 | 44 | +14 | The Boondock Saints II: All Saints Day | $26,800 | $29,472 | +$2,672 | +10% | 50 | $10,142,000 | $10,143,744 | 12 | Apparition | - |
| 31 | 45 | +14 | Bad Lieutenant: Port of Call New Orleans | $26,100 | $26,457 | +$357 | +1.4% | 43 | $1,547,000 | $1,540,521 | 9 | First Look International | - |
| 32 | 47 | +15 | Me and Orson Welles | $24,900 | $24,221 | -$679 | -2.7% | 21 | $1,065,000 | $1,063,909 | 8 | Freestyle Releasing | - |
| 33 | 54 | +21 | Astro Boy | $18,000 | $14,013 | -$3,987 | -22.2% | 54 | $19,546,000 | $19,541,847 | 13 | Summit Entertainment | - |
| 34 | 49 | +15 | The Messenger | $17,200 | $18,240 | +$1,040 | +6% | 23 | $710,000 | $710,650 | 10 | Oscilloscope | - |
