| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $465,219 | -28.8% | 74 | - | $6,286 | $1,997,329 | 3 | 20th Century Fox International | false | false |
| 2 | 2 | Babel | $235,684 | -22.5% | 41 | +1 | $5,748 | $850,660 | 3 | United International Pictures | false | false |
| 3 | - | Apocalypto | $197,032 | - | 29 | - | $6,794 | $197,032 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | Deja Vu | $154,339 | -22.7% | 52 | -1 | $2,968 | $1,465,506 | 5 | Buena Vista International | false | false |
| 5 | - | The Pursuit of Happyness | $114,270 | - | 32 | - | $3,570 | $114,270 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | Flushed Away | $107,008 | -38.5% | 89 | -1 | $1,202 | $1,446,001 | 5 | United International Pictures | false | false |
| 7 | 5 | The Holiday | $83,779 | -26% | 42 | - | $1,994 | $537,659 | 4 | United International Pictures | false | false |
| 8 | - | A Prairie Home Companion | $69,061 | - | 12 | - | $5,755 | $69,061 | 1 | Distribution Company | true | false |
| 9 | 6 | Charlotte's Web | $63,340 | -41.4% | 40 | - | $1,583 | $172,941 | 2 | United International Pictures | false | false |
| 10 | 7 | Marie Antoinette | $61,474 | -40.7% | 14 | - | $4,391 | $165,859 | 2 | Sony Pictures Releasing | false | false |
| 11 | 8 | Eragon | $50,171 | -46% | 69 | -1 | $727 | $1,027,101 | 5 | 20th Century Fox International | false | false |
| 12 | 9 | Flags of Our Fathers | $40,786 | -49.5% | 14 | -1 | $2,913 | $122,075 | 2 | Warner Bros. | false | false |
| 13 | - | Dragones: destino de fuego | $37,465 | - | 40 | - | $936 | $37,465 | 1 | Pachamama Cine | true | false |
| 14 | 10 | The Departed | $31,370 | -37.3% | 34 | -13 | $922 | $1,809,597 | 12 | Warner Bros. | false | false |
| 15 | - | Hollywoodland | $26,641 | - | 14 | - | $1,902 | $26,641 | 1 | Buena Vista International | true | false |
| 16 | 13 | The Grudge 2 | $20,497 | -43.3% | 34 | -5 | $602 | $195,898 | 4 | Alfa Films | false | false |
| 17 | 19 | Pan's Labyrinth | $17,830 | -10% | 10 | - | $1,783 | $123,191 | 5 | Warner Bros. | false | false |
| 18 | 12 | Tsotsi | $17,064 | -56.7% | 14 | - | $1,218 | $56,752 | 2 | Alfa Films | false | false |
| 19 | 11 | Tenacious D in the Pick of Destiny | $16,967 | -64.4% | 19 | -2 | $893 | $64,992 | 2 | Distribution Company | false | false |
| 20 | 15 | Little Children | $16,837 | -23.2% | 20 | - | $841 | $231,596 | 5 | Distribution Company | false | false |
