| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $355,634 | -23.6% | 86 | +12 | $4,135 | $2,340,017 | 4 | 20th Century Fox International | false | false |
| 2 | - | Hoodwinked! | $225,148 | - | 43 | - | $5,236 | $225,148 | 1 | Alfa Films | true | false |
| 3 | - | Blood Diamond | $223,660 | - | 45 | - | $4,970 | $223,660 | 1 | Warner Bros. | true | false |
| 4 | - | Who Says It's Easy? | $213,082 | - | 42 | - | $5,073 | $213,082 | 1 | Primer Plano Film Group | true | false |
| 5 | 2 | Babel | $194,656 | -17.4% | 47 | +6 | $4,141 | $1,039,803 | 4 | United International Pictures | false | false |
| 6 | 3 | Apocalypto | $128,202 | -34.9% | 28 | -1 | $4,578 | $323,957 | 2 | 20th Century Fox International | false | false |
| 7 | 4 | Deja Vu | $117,046 | -24.2% | 53 | +1 | $2,208 | $1,573,054 | 6 | Buena Vista International | false | false |
| 8 | - | Borat | $87,488 | - | 19 | - | $4,604 | $87,488 | 1 | 20th Century Fox International | true | false |
| 9 | 5 | The Pursuit of Happyness | $69,150 | -39.5% | 32 | - | $2,160 | $182,679 | 2 | Sony Pictures Releasing | false | false |
| 10 | 6 | Flushed Away | $56,687 | -47% | 78 | -11 | $726 | $1,493,316 | 6 | United International Pictures | false | false |
| 11 | 7 | The Holiday | $54,396 | -35.1% | 41 | -1 | $1,326 | $588,570 | 5 | United International Pictures | false | false |
| 12 | 8 | A Prairie Home Companion | $40,293 | -41.7% | 12 | - | $3,357 | $108,906 | 2 | Distribution Company | false | false |
| 13 | 10 | Marie Antoinette | $39,820 | -35.2% | 14 | - | $2,844 | $204,604 | 3 | Sony Pictures Releasing | false | false |
| 14 | 9 | Charlotte's Web | $30,493 | -51.9% | 40 | - | $762 | $202,314 | 3 | United International Pictures | false | false |
| 15 | 11 | Eragon | $26,304 | -47.6% | 49 | -20 | $536 | $1,046,748 | 6 | 20th Century Fox International | false | false |
| 16 | - | Dreamgirls | $22,986 | - | 9 | - | $2,554 | $22,986 | 1 | United International Pictures | true | false |
| 17 | 12 | Flags of Our Fathers | $19,356 | -52.5% | 14 | - | $1,382 | $140,640 | 3 | Warner Bros. | false | false |
| 18 | 14 | The Departed | $19,055 | -39.3% | 20 | -14 | $952 | $1,816,923 | 13 | Warner Bros. | false | false |
| 19 | 17 | Pan's Labyrinth | $13,407 | -24.8% | 10 | - | $1,340 | $135,800 | 6 | Warner Bros. | false | false |
| 20 | 13 | Dragones: destino de fuego | $12,390 | -66.9% | 31 | -9 | $399 | $49,612 | 2 | Pachamama Cine | false | false |
