| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $194,448 | -31.1% | 54 | +13 | $3,600 | $1,317,144 | 4 | 20th Century Fox International | false | false |
| 2 | - | Rocky Balboa | $135,624 | - | 43 | - | $3,154 | $135,624 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Babel | $100,726 | -18.8% | 33 | - | $3,052 | $564,753 | 4 | United International Pictures | false | false |
| 4 | 3 | Blood Diamond | $85,594 | -19.3% | 27 | +4 | $3,170 | $190,735 | 2 | Warner Bros. | false | false |
| 5 | - | The Pursuit of Happyness | $56,547 | - | 11 | - | $5,140 | $56,547 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | The Illusionist | $40,934 | -19.8% | 15 | -5 | $2,728 | $348,606 | 5 | Transeuropa | false | false |
| 7 | 5 | Eragon | $25,238 | -50.4% | 17 | -7 | $1,484 | $803,972 | 6 | 20th Century Fox International | false | false |
| 8 | 8 | Deja Vu | $25,049 | -24% | 14 | -6 | $1,789 | $244,342 | 5 | Buena Vista International | false | false |
| 9 | 7 | Flushed Away | $23,778 | -30.8% | 21 | -4 | $1,132 | $996,779 | 9 | United International Pictures | false | false |
| 10 | 6 | Children of Men | $22,388 | -47.7% | 15 | -10 | $1,492 | $122,387 | 3 | United International Pictures | false | false |
| 11 | 11 | The Departed | $18,178 | -23.7% | 8 | -1 | $2,272 | $764,844 | 13 | Warner Bros. | false | false |
| 12 | 9 | Flags of Our Fathers | $15,811 | -43.8% | 10 | - | $1,581 | $76,234 | 3 | Warner Bros. | false | false |
| 13 | 12 | Cry Wolf | $15,281 | -28.3% | 11 | +1 | $1,389 | $36,407 | 2 | Bazuca Films | false | false |
| 14 | 13 | Charlotte's Web | $12,734 | -21.9% | 11 | -2 | $1,157 | $138,289 | 5 | United International Pictures | false | false |
| 15 | 14 | Marie Antoinette | $4,555 | -67.4% | 2 | -2 | $2,277 | $99,298 | 5 | Sony Pictures Releasing | false | false |
| 16 | - | By the Pricking of My Thumbs | $4,369 | - | 4 | - | $1,092 | $4,369 | 1 | Transeuropa | true | false |
| 17 | 15 | Happy Feet | $4,033 | -63% | 7 | - | $576 | $798,596 | 11 | Warner Bros. | false | false |
| 18 | 10 | Little Miss Sunshine | $3,853 | -85.5% | 4 | - | $963 | $118,573 | 8 | 20th Century Fox International | false | false |
| 19 | - | A Movie of Eggs | $3,773 | - | 4 | - | $943 | $49,685 | 5 | Warner Bros. | false | false |
| 20 | 17 | Casino Royale | $2,849 | -53.5% | 1 | -1 | $2,849 | $773,467 | 10 | Sony Pictures Releasing | false | false |
