| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum | $299,854 | -15.7% | 89 | +3 | $3,369 | $2,642,052 | 5 | 20th Century Fox International | false | false |
| 2 | 4 | Who Says It's Easy? | $237,748 | +11.6% | 53 | +11 | $4,485 | $451,028 | 2 | Primer Plano Film Group | false | false |
| 3 | 2 | Hoodwinked! | $206,111 | -8.5% | 43 | - | $4,793 | $431,469 | 2 | Alfa Films | false | false |
| 4 | 3 | Blood Diamond | $176,246 | -21.2% | 44 | -1 | $4,005 | $400,115 | 2 | Warner Bros. | false | false |
| 5 | 5 | Babel | $167,929 | -13.7% | 47 | - | $3,572 | $1,208,701 | 5 | United International Pictures | false | false |
| 6 | - | Perfume: The Story of a Murderer | $106,459 | - | 24 | - | $4,435 | $106,459 | 1 | Distribution Company | true | false |
| 7 | - | Letters from Iwo Jima | $102,088 | - | 14 | - | $7,292 | $102,088 | 1 | Warner Bros. | true | false |
| 8 | 6 | Apocalypto | $94,234 | -26.5% | 30 | +2 | $3,141 | $418,492 | 3 | 20th Century Fox International | false | false |
| 9 | 7 | Deja Vu | $93,162 | -20.4% | 52 | -1 | $1,791 | $1,667,681 | 7 | Buena Vista International | false | false |
| 10 | 8 | Borat | $70,045 | -19.9% | 20 | +1 | $3,502 | $157,614 | 2 | 20th Century Fox International | false | false |
| 11 | - | The Last King of Scotland | $42,063 | - | 14 | - | $3,004 | $42,063 | 1 | 20th Century Fox International | true | false |
| 12 | 9 | The Pursuit of Happyness | $41,778 | -39.6% | 31 | -1 | $1,347 | $224,627 | 3 | Sony Pictures Releasing | false | false |
| 13 | 10 | Flushed Away | $39,825 | -29.7% | 63 | -15 | $632 | $1,534,532 | 7 | United International Pictures | false | false |
| 14 | 11 | The Holiday | $37,579 | -30.9% | 41 | - | $916 | $626,698 | 6 | United International Pictures | false | false |
| 15 | 14 | Charlotte's Web | $33,520 | +9.9% | 40 | - | $838 | $236,022 | 4 | United International Pictures | false | false |
| 16 | 13 | Marie Antoinette | $31,233 | -21.6% | 14 | - | $2,230 | $236,028 | 4 | Sony Pictures Releasing | false | false |
| 17 | 12 | A Prairie Home Companion | $25,823 | -35.9% | 12 | - | $2,151 | $134,830 | 3 | Distribution Company | false | false |
| 18 | 17 | Flags of Our Fathers | $16,072 | -17% | 14 | - | $1,148 | $156,843 | 4 | Warner Bros. | false | false |
| 19 | 18 | The Departed | $14,433 | -24.3% | 15 | -5 | $962 | $1,833,050 | 14 | Warner Bros. | false | false |
| 20 | 19 | Pan's Labyrinth | $13,986 | +4.3% | 10 | - | $1,398 | $149,913 | 7 | Warner Bros. | false | false |
