| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Queen | $236,134 | - | 32 | - | $7,379 | $236,134 | 1 | Distribution Company | true | false |
| 2 | 1 | Night at the Museum | $197,719 | -34.1% | 92 | +3 | $2,149 | $2,839,771 | 6 | 20th Century Fox International | false | false |
| 3 | 2 | Who Says It's Easy? | $181,318 | -23.7% | 54 | +1 | $3,357 | $632,346 | 3 | Primer Plano Film Group | false | false |
| 4 | - | The Good Shepherd | $145,801 | - | 40 | - | $3,645 | $145,801 | 1 | United International Pictures | true | false |
| 5 | 3 | Hoodwinked! | $137,223 | -33.4% | 44 | +1 | $3,118 | $568,692 | 3 | Alfa Films | false | false |
| 6 | 5 | Babel | $131,840 | -21.5% | 47 | - | $2,805 | $1,354,006 | 6 | United International Pictures | false | false |
| 7 | 4 | Blood Diamond | $130,735 | -25.8% | 46 | +2 | $2,842 | $530,850 | 3 | Warner Bros. | false | false |
| 8 | 8 | Apocalypto | $87,265 | -7.4% | 29 | -1 | $3,009 | $505,758 | 4 | 20th Century Fox International | false | false |
| 9 | 9 | Deja Vu | $63,466 | -31.9% | 48 | -4 | $1,322 | $1,731,147 | 8 | Buena Vista International | false | false |
| 10 | 7 | Letters from Iwo Jima | $60,421 | -40.8% | 14 | - | $4,315 | $162,509 | 2 | Warner Bros. | false | false |
| 11 | 6 | Perfume: The Story of a Murderer | $60,183 | -43.5% | 24 | - | $2,507 | $166,642 | 2 | Distribution Company | false | false |
| 12 | 10 | Borat | $38,909 | -44.5% | 20 | - | $1,945 | $196,523 | 3 | 20th Century Fox International | false | false |
| 13 | - | See No Evil | $33,675 | - | 23 | - | $1,464 | $33,675 | 1 | Alfa Films | true | false |
| 14 | 12 | The Pursuit of Happyness | $25,792 | -38.3% | 31 | - | $832 | $250,419 | 4 | Sony Pictures Releasing | false | false |
| 15 | 13 | Flushed Away | $25,756 | -35.3% | 58 | -5 | $444 | $1,568,487 | 8 | United International Pictures | false | false |
| 16 | 15 | Charlotte's Web | $21,793 | -35% | 39 | -1 | $558 | $260,732 | 5 | United International Pictures | false | false |
| 17 | 11 | The Last King of Scotland | $21,393 | -49.1% | 14 | - | $1,528 | $63,456 | 2 | 20th Century Fox International | false | false |
| 18 | 16 | Marie Antoinette | $21,130 | -32.3% | 14 | - | $1,509 | $257,157 | 5 | Sony Pictures Releasing | false | false |
| 19 | 18 | Flags of Our Fathers | $16,729 | +4.1% | 14 | - | $1,194 | $173,572 | 5 | Warner Bros. | false | false |
| 20 | 14 | The Holiday | $16,626 | -55.8% | 30 | -11 | $554 | $645,356 | 7 | United International Pictures | false | false |
