| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Rocky Balboa | $199,946 | - | 37 | - | $5,403 | $199,946 | 1 | 20th Century Fox International | true | false |
| 2 | 3 | Who Says It's Easy? | $180,093 | -0.7% | 54 | - | $3,335 | $813,421 | 4 | Primer Plano Film Group | false | false |
| 3 | 1 | The Queen | $176,522 | -25.2% | 32 | - | $5,516 | $413,023 | 2 | Distribution Company | false | false |
| 4 | 2 | Night at the Museum | $158,724 | -19.7% | 91 | -1 | $1,744 | $3,002,901 | 7 | 20th Century Fox International | false | false |
| 5 | 6 | Babel | $124,089 | -5.9% | 47 | - | $2,640 | $1,489,131 | 7 | United International Pictures | false | false |
| 6 | 7 | Blood Diamond | $122,111 | -6.6% | 44 | -2 | $2,775 | $653,785 | 4 | Warner Bros. | false | false |
| 7 | 4 | The Good Shepherd | $107,014 | -26.6% | 41 | +1 | $2,610 | $262,671 | 2 | United International Pictures | false | false |
| 8 | - | The Departed | $102,414 | - | 52 | - | $1,969 | $1,954,297 | 16 | Warner Bros. | false | false |
| 9 | 5 | Hoodwinked! | $95,509 | -30.4% | 44 | - | $2,170 | $665,083 | 4 | Alfa Films | false | false |
| 10 | 8 | Apocalypto | $81,487 | -6.6% | 29 | - | $2,809 | $588,029 | 5 | 20th Century Fox International | false | false |
| 11 | 9 | Deja Vu | $51,731 | -18.5% | 51 | +3 | $1,014 | $1,785,565 | 9 | Buena Vista International | false | false |
| 12 | 10 | Letters from Iwo Jima | $45,967 | -23.9% | 14 | - | $3,283 | $208,728 | 3 | Warner Bros. | false | false |
| 13 | 11 | Perfume: The Story of a Murderer | $42,569 | -29.3% | 24 | - | $1,773 | $209,459 | 3 | Distribution Company | false | false |
| 14 | - | Time to Leave | $37,986 | - | 12 | - | $3,165 | $37,986 | 1 | Alfa Films | true | false |
| 15 | 12 | Borat | $29,967 | -23% | 18 | -2 | $1,664 | $226,795 | 4 | 20th Century Fox International | false | false |
| 16 | 14 | The Pursuit of Happyness | $25,026 | -3% | 29 | -2 | $862 | $275,833 | 5 | Sony Pictures Releasing | false | false |
| 17 | 17 | The Last King of Scotland | $22,085 | +3.2% | 14 | - | $1,577 | $85,639 | 3 | 20th Century Fox International | false | false |
| 18 | 13 | See No Evil | $21,824 | -35.2% | 24 | +1 | $909 | $55,552 | 2 | Alfa Films | false | false |
| 19 | 16 | Charlotte's Web | $18,801 | -13.7% | 38 | -1 | $494 | $280,844 | 6 | United International Pictures | false | false |
| 20 | 18 | Marie Antoinette | $16,195 | -23.4% | 14 | - | $1,156 | $273,752 | 6 | Sony Pictures Releasing | false | false |
