| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 300 | $612,191 | - | 76 | - | $8,055 | $612,191 | 1 | Warner Bros. | true | false |
| 2 | 3 | Arthur and the Invisibles | $52,115 | +11% | 23 | -2 | $2,265 | $146,070 | 3 | Bazuca Films | false | false |
| 3 | 1 | Apocalypto | $34,062 | -42.8% | 19 | -1 | $1,792 | $264,153 | 4 | 20th Century Fox International | false | false |
| 4 | 4 | Music and Lyrics | $32,597 | -27.8% | 24 | -3 | $1,358 | $137,509 | 3 | Warner Bros. | false | false |
| 5 | 5 | Night at the Museum | $31,750 | -14.3% | 32 | -2 | $992 | $1,876,256 | 11 | 20th Century Fox International | false | false |
| 6 | - | Captain Alatriste: The Spanish Musketeer | $27,101 | - | 10 | - | $2,710 | $27,101 | 1 | 20th Century Fox International | true | false |
| 7 | 2 | Curse of the Golden Flower | $25,198 | -46.8% | 11 | -2 | $2,290 | $72,393 | 2 | Sony Pictures Releasing | false | false |
| 8 | 6 | Borat | $19,725 | -36.7% | 8 | - | $2,465 | $96,646 | 3 | 20th Century Fox International | false | false |
| 9 | 7 | The Holiday | $19,166 | -32.2% | 14 | -9 | $1,369 | $275,961 | 6 | United International Pictures | false | false |
| 10 | 9 | Pan's Labyrinth | $15,267 | -35.7% | 9 | +3 | $1,696 | $204,067 | 6 | Warner Bros. | false | false |
| 11 | 10 | Blood Diamond | $10,332 | -53.2% | 13 | -11 | $794 | $464,040 | 9 | Warner Bros. | false | false |
| 12 | 14 | The Pursuit of Happyness | $9,774 | -26% | 10 | -1 | $977 | $228,145 | 8 | Sony Pictures Releasing | false | false |
| 13 | - | Breaking and Entering | $9,172 | - | 2 | - | $4,586 | $9,172 | 1 | Buena Vista International | true | false |
| 14 | 12 | Notes on a Scandal | $8,009 | -43.4% | 3 | -2 | $2,669 | $94,403 | 5 | 20th Century Fox International | false | false |
| 15 | 15 | The Illusionist | $6,628 | -48.3% | 6 | -6 | $1,104 | $507,489 | 12 | Transeuropa | false | false |
| 16 | 16 | The Last King of Scotland | $4,875 | -50.8% | 4 | - | $1,218 | $100,685 | 7 | 20th Century Fox International | false | false |
| 17 | 17 | Letters from Iwo Jima | $3,706 | -53.8% | 7 | - | $529 | $143,637 | 7 | Warner Bros. | false | false |
| 18 | - | Deja Vu | $2,232 | - | 1 | - | $2,232 | $323,773 | 12 | Buena Vista International | false | false |
| 19 | - | Happy Feet | $1,572 | - | 3 | - | $524 | $819,530 | 18 | Warner Bros. | false | false |
| 20 | - | A Movie of Eggs | $495 | - | 3 | - | $165 | $59,996 | 12 | Warner Bros. | false | false |
| 21 | - | Ice Age: The Meltdown | $104 | - | 1 | - | $104 | $3,580,424 | 53 | N/A | false | false |
| 22 | - | Garfield: A Tail of Two Kitties | $28 | - | 1 | - | $28 | $761,213 | 37 | 20th Century Fox International | false | false |
