| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Fly | $7,126,158 | -35% | 1,201 | +6 | $5,933 | $18,081,361 | 2 | Twentieth Century Fox | false | false |
| 2 | 19 | Stand by Me | $6,022,475 | +1,205.8% | 745 | +729 | $8,083 | $6,894,884 | 3 | Columbia Pictures | false | false |
| 3 | 5 | Top Gun | $5,206,339 | -2.1% | 1,201 | -15 | $4,335 | $126,320,911 | 15 | Paramount Pictures | false | false |
| 4 | 2 | Aliens | $5,162,196 | -25.3% | 1,280 | -22 | $4,032 | $62,768,219 | 6 | Twentieth Century Fox | false | false |
| 5 | 4 | The Karate Kid Part II | $4,325,479 | -20.3% | 1,549 | -21 | $2,792 | $95,171,704 | 10 | Columbia Pictures | false | false |
| 6 | - | The Texas Chainsaw Massacre 2 | $3,973,024 | - | 1,474 | - | $2,695 | $3,973,024 | 1 | Cannon Film Distributors | true | false |
| 7 | 3 | Armed and Dangerous | $3,885,195 | -40.5% | 1,557 | +5 | $2,495 | $10,416,512 | 2 | Columbia Pictures | false | false |
| 8 | - | Extremities | $3,884,034 | - | 605 | - | $6,419 | $3,884,034 | 1 | Atlantic Releasing Corporation | true | false |
| 9 | 6 | Nothing in Common | $3,829,832 | -19.2% | 951 | +108 | $4,027 | $18,573,959 | 4 | TriStar Pictures | false | false |
| 10 | 7 | Ruthless People | $3,192,056 | -17.7% | 954 | -65 | $3,345 | $56,436,213 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 11 | 8 | Manhunter | $1,971,392 | -41.8% | 767 | -12 | $2,570 | $5,360,877 | 2 | De Laurentiis Entertainment Group (DEG) | false | false |
| 12 | 12 | Back to School | $1,936,285 | -22.1% | 779 | -131 | $2,485 | $78,638,987 | 11 | Orion Pictures | false | false |
| 13 | 10 | Flight of the Navigator | $1,834,679 | -29.8% | 916 | -45 | $2,002 | $14,503,110 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 14 | 9 | One Crazy Summer | $1,826,158 | -45.9% | 792 | -192 | $2,305 | $10,738,179 | 3 | Warner Bros. | false | false |
| 15 | 15 | Ferris Bueller's Day Off | $1,814,654 | -13.6% | 685 | -93 | $2,649 | $59,475,172 | 12 | Paramount Pictures | false | false |
| 16 | 14 | About Last Night | $1,799,558 | -24.3% | 787 | -93 | $2,286 | $31,013,282 | 8 | TriStar Pictures | false | false |
| 17 | 11 | Heartburn | $1,617,657 | -35.3% | 699 | -103 | $2,314 | $21,513,544 | 5 | Paramount Pictures | false | false |
| 18 | 17 | The Transformers: The Movie | $831,731 | -45.1% | 846 | -144 | $983 | $5,163,645 | 3 | De Laurentiis Entertainment Group (DEG) | false | false |
| 19 | 16 | Howard the Duck | $569,100 | -66.3% | 349 | -565 | $1,630 | $14,638,688 | 4 | Universal Pictures | false | false |
| 20 | - | Night of the Creeps | $303,982 | - | 70 | - | $4,342 | $303,982 | 1 | TriStar Pictures | true | false |
| 21 | - | Touch and Go | $186,691 | - | 51 | - | $3,660 | $186,691 | 1 | TriStar Pictures | true | false |
