| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Fly II | $8,395,197 | - | 1,524 | - | $5,508 | $8,395,197 | 1 | Twentieth Century Fox | true | false |
| 2 | 2 | Three Fugitives | $6,504,585 | -4.6% | 1,374 | +183 | $4,734 | $21,464,084 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 3 | 1 | Rain Man | $6,213,455 | -9.4% | 1,573 | - | $3,950 | $103,896,697 | 9 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 4 | 4 | Beaches | $4,904,366 | -10.1% | 1,122 | +13 | $4,371 | $32,084,483 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 5 | 3 | Her Alibi | $4,498,499 | -28% | 1,429 | - | $3,148 | $10,745,777 | 2 | Warner Bros. | false | false |
| 6 | - | Cousins | $4,127,669 | - | 535 | - | $7,715 | $4,127,669 | 1 | Paramount Pictures | true | false |
| 7 | 6 | Twins | $3,661,120 | -10.1% | 1,512 | -97 | $2,421 | $95,180,515 | 10 | Universal Pictures | false | false |
| 8 | 5 | Who's Harry Crumb? | $2,931,506 | -37.2% | 1,198 | +1 | $2,447 | $7,602,587 | 2 | TriStar Pictures | false | false |
| 9 | - | Tap | $2,922,075 | - | 585 | - | $4,995 | $2,922,075 | 1 | TriStar Pictures | true | false |
| 10 | 7 | Working Girl | $2,841,392 | -11.5% | 1,100 | -33 | $2,583 | $45,232,311 | 8 | Twentieth Century Fox | false | false |
| 11 | 8 | Mississippi Burning | $2,415,960 | -24.2% | 1,056 | -18 | $2,287 | $21,383,332 | 10 | Orion Pictures | false | false |
| 12 | 11 | Dangerous Liaisons | $2,132,484 | +43.3% | 347 | +228 | $6,145 | $8,994,127 | 8 | Warner Bros. | false | false |
| 13 | 9 | The Naked Gun: From the Files of Police Squad! | $1,769,889 | -24.4% | 1,026 | -232 | $1,725 | $73,168,302 | 11 | Paramount Pictures | false | false |
| 14 | 10 | The Accidental Tourist | $1,186,282 | -37.4% | 565 | -191 | $2,099 | $25,560,701 | 8 | Warner Bros. | false | false |
