| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Ted | $218,815,487 | 3,303 | $54,415,205 | 3,239 | Jun 29, 2012 | Universal Pictures |
| 2 | Big Daddy | $163,479,795 | 3,254 | $41,536,370 | 3,027 | Jun 25, 1999 | Sony Pictures Releasing |
| 3 | Grown Ups | $162,001,186 | 3,534 | $40,506,562 | 3,534 | Jun 25, 2010 | Sony Pictures Releasing |
| 4 | Neighbors | $150,157,400 | 3,311 | $49,033,915 | 3,279 | May 9, 2014 | Universal Pictures |
| 5 | Knocked Up | $148,768,917 | 2,975 | $30,690,990 | 2,871 | Jun 1, 2007 | Universal Pictures |
| 6 | 21 Jump Street | $138,447,667 | 3,148 | $36,302,612 | 3,121 | Mar 16, 2012 | Sony Pictures Releasing |
| 7 | The 40-Year-Old Virgin | $109,449,237 | 3,006 | $21,422,815 | 2,845 | Aug 19, 2005 | Universal Pictures |
| 8 | Step Brothers | $100,468,793 | 3,182 | $30,940,732 | 3,094 | Jul 25, 2008 | Sony Pictures Releasing |
| 9 | Failure to Launch | $88,715,192 | 3,202 | $24,411,322 | 3,057 | Mar 10, 2006 | Paramount Pictures |
| 10 | School of Rock | $81,261,177 | 2,951 | $19,622,714 | 2,614 | Oct 3, 2003 | Paramount Pictures |
| 11 | You, Me and Dupree | $75,628,110 | 3,137 | $21,525,560 | 3,131 | Jul 14, 2006 | Universal Pictures |
| 12 | Old School | $75,585,093 | 2,742 | $17,453,216 | 2,689 | Feb 21, 2003 | DreamWorks Distribution |
| 13 | I Love You, Man | $71,440,011 | 2,829 | $17,810,270 | 2,711 | Mar 20, 2009 | DreamWorks |
| 14 | Role Models | $67,294,270 | 2,798 | $19,167,085 | 2,792 | Nov 7, 2008 | Universal Pictures |
| 15 | Forgetting Sarah Marshall | $63,172,463 | 2,872 | $17,725,330 | 2,798 | Apr 18, 2008 | Universal Pictures |
| 16 | Hall Pass | $45,060,734 | 2,950 | $13,535,374 | 2,950 | Feb 25, 2011 | Warner Bros. |
| 17 | That's My Boy | $36,931,089 | 3,030 | $13,453,714 | 3,030 | Jun 15, 2012 | Sony Pictures Releasing |
| 18 | Drillbit Taylor | $32,862,104 | 3,061 | $10,309,986 | 3,056 | Mar 21, 2008 | Paramount Pictures |
| 19 | She's Out of My League | $32,010,860 | 2,958 | $9,775,278 | 2,956 | Mar 12, 2010 | Paramount Pictures |
| 20 | Young Adult | $16,311,571 | 987 | $310,263 | 8 | Dec 9, 2011 | Paramount Pictures |
| 21 | The Rocker | $6,409,528 | 2,784 | $2,636,048 | 2,784 | Aug 20, 2008 | Twentieth Century Fox |
| 22 | Grandma's Boy | $6,090,172 | 2,016 | $3,009,341 | 2,015 | Jan 6, 2006 | Twentieth Century Fox |
| 23 | Jeff, Who Lives at Home | $4,269,426 | 513 | $855,709 | 254 | Mar 16, 2012 | Paramount Vantage |
| 24 | The Brothers Solomon | $900,926 | 700 | $508,601 | 700 | Sep 7, 2007 | Screen Gems |
