| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Marley & Me | - | - | - | $14,380,980 | 3,505 | $143,153,751 | Dec 25 | Twentieth Century Fox | false |
| 2 | The Curious Case of Benjamin Button | - | - | - | $11,871,831 | 2,988 | $127,509,326 | Dec 25 | Paramount Pictures | false |
| 3 | Bedtime Stories | - | - | - | $10,578,817 | 3,684 | $110,101,975 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 4 | Valkyrie | - | - | - | $8,493,972 | 2,838 | $83,077,833 | Dec 25 | United Artists | false |
| 5 | Yes Man | - | - | - | $5,929,964 | 3,434 | $97,690,976 | Dec 19 | Warner Bros. | false |
| 6 | Seven Pounds | - | - | - | $4,747,447 | 2,758 | $69,951,824 | Dec 19 | Sony Pictures Releasing | false |
| 7 | The Spirit | - | - | - | $3,842,223 | 2,509 | $19,806,188 | Dec 25 | Lionsgate | false |
| 8 | The Day the Earth Stood Still | - | - | - | $2,768,754 | 3,560 | $79,366,978 | Dec 12 | Twentieth Century Fox | false |
| 9 | Four Christmases | - | - | - | $2,236,109 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 10 | The Tale of Despereaux | - | - | - | $1,971,040 | 3,107 | $50,877,145 | Dec 19 | Universal Pictures | false |
| 11 | Doubt | - | - | - | $1,420,480 | 1,287 | $33,446,470 | Dec 12 | Miramax | false |
| 12 | Slumdog Millionaire | - | - | - | $1,345,137 | 2,943 | $141,319,928 | Nov 12 | Fox Searchlight Pictures | false |
| 13 | Twilight | - | - | - | $991,486 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 14 | Gran Torino | - | - | - | $763,558 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 15 | Bolt | - | - | - | $676,609 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 16 | Milk | - | - | - | $496,665 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 17 | Frost/Nixon | - | - | - | $471,095 | 1,105 | $18,622,031 | Dec 5 | Universal Pictures | false |
| 18 | Ghajini | - | - | - | $456,734 | 83 | $2,430,627 | Dec 24 | Adlabs Films | false |
| 19 | Quantum of Solace | - | - | - | $363,158 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 20 | Australia | - | - | - | $225,631 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 21 | The Reader | - | - | - | $174,588 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 22 | Nothing Like the Holidays | - | - | - | $169,856 | 1,671 | $7,503,736 | Dec 12 | Overture Films | false |
| 23 | Madagascar: Escape 2 Africa | - | - | - | $150,918 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 24 | The Wrestler | - | - | - | $134,626 | 776 | $26,238,243 | Dec 17 | Fox Searchlight Pictures | false |
| 25 | Cadillac Records | - | - | - | $85,084 | 701 | $8,195,551 | Dec 5 | Sony Pictures Releasing | false |
| 26 | Role Models | - | - | - | $59,625 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 27 | Beverly Hills Chihuahua | - | - | - | $54,300 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 28 | Transporter 3 | - | - | - | $44,015 | 2,626 | $31,715,062 | Nov 26 | Lionsgate | false |
| 29 | Last Chance Harvey | - | - | - | $35,674 | 1,108 | $14,889,042 | Dec 25 | Overture Films | false |
| 30 | Eagle Eye | - | - | - | $29,424 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 31 | High School Musical 3: Senior Year | - | - | - | $27,183 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 32 | The Boy in the Striped Pajamas | - | - | - | $20,664 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 33 | Body of Lies | - | - | - | $15,292 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 34 | The Polar Express 2008 IMAX Release | - | - | - | $15,153 | 26 | $1,705,694 | Nov 21 | Warner Bros. | false |
| 35 | Happy-Go-Lucky | - | - | - | $13,313 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 36 | Changeling | - | - | - | $10,830 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 37 | Vicky Cristina Barcelona | - | - | - | $9,897 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 38 | Nights in Rodanthe | - | - | - | $7,277 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 39 | The Dark Knight | - | - | - | $6,974 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 40 | The Secret Life of Bees | - | - | - | $6,126 | 1,630 | $37,770,162 | Oct 17 | Fox Searchlight Pictures | false |
| 41 | Burn After Reading | - | - | - | $4,889 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 42 | The Haunting of Molly Hartley | - | - | - | $4,147 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 43 | Zack and Miri Make a Porno | - | - | - | $3,419 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 44 | Max Payne | - | - | - | $3,231 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 45 | Igor | - | - | - | $1,749 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 46 | City of Ember | - | - | - | $1,552 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 47 | Appaloosa | - | - | - | $1,363 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 48 | WALL·E | - | - | - | $1,318 | 3,992 | $223,808,164 | Jun 27 | Walt Disney Studios Motion Pictures | false |
| 49 | RocknRolla | - | - | - | $1,109 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 50 | Soul Men | - | - | - | $905 | 2,048 | $12,082,391 | Nov 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 51 | Deep Sea | - | - | - | $434 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 52 | Were the World Mine | - | - | - | $392 | 4 | $123,789 | Oct 31 | SPEAK Productions | false |
