| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Scary Movie 4 | - | - | - | $7,762,176 | 3,674 | $90,710,620 | Apr 14 | Dimension Films | false |
| 2 | Ice Age 2: The Meltdown | - | - | - | $4,666,546 | 3,969 | $195,330,621 | Mar 31 | Twentieth Century Fox | false |
| 3 | The Benchwarmers | - | - | - | $2,209,102 | 3,282 | $59,843,754 | Apr 7 | Revolution Studios | false |
| 4 | The Wild | - | - | - | $2,123,688 | 2,854 | $37,384,046 | Apr 14 | Walt Disney Studios Motion Pictures | false |
| 5 | Take the Lead | - | - | - | $1,776,000 | 3,009 | $34,742,066 | Apr 7 | New Line Cinema | true |
| 6 | Inside Man | - | - | - | $1,659,590 | 2,867 | $88,513,495 | Mar 24 | Universal Pictures | false |
| 7 | Lucky Number Slevin | - | - | - | $1,289,320 | 1,989 | $22,495,466 | Apr 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 8 | Thank You for Smoking | - | - | - | $1,044,832 | 1,020 | $24,793,509 | Mar 17 | Fox Searchlight Pictures | false |
| 9 | Failure to Launch | - | - | - | $619,052 | 3,202 | $88,715,192 | Mar 10 | Paramount Pictures | false |
| 10 | V for Vendetta | - | - | - | $596,416 | 3,365 | $70,511,035 | Mar 17 | Warner Bros. | false |
| 11 | Phat Girlz | - | - | - | $394,581 | 1,060 | $7,061,128 | Apr 7 | Fox Searchlight Pictures | false |
| 12 | ATL | - | - | - | $373,766 | 1,602 | $21,170,563 | Mar 31 | Warner Bros. | false |
| 13 | My Brother's Wife | - | - | - | $329,153 | 217 | $2,808,241 | Apr 14 | Lionsgate | false |
| 14 | She's the Man | - | - | - | $212,286 | 2,631 | $33,741,133 | Mar 17 | DreamWorks | false |
| 15 | Friends with Money | - | - | - | $198,000 | 1,010 | $13,368,437 | Apr 7 | Sony Pictures Classics | true |
| 16 | Stay Alive | - | - | - | $185,733 | 2,009 | $23,086,480 | Mar 24 | Walt Disney Studios Motion Pictures | false |
| 17 | Larry the Cable Guy: Health Inspector | - | - | - | $151,779 | 1,747 | $15,680,099 | Mar 24 | Lionsgate | false |
| 18 | Deep Sea | - | - | - | $94,224 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 19 | Slither | - | - | - | $91,980 | 1,946 | $7,802,450 | Mar 31 | Universal Pictures | false |
| 20 | The Shaggy Dog | - | - | - | $79,063 | 3,501 | $61,123,569 | Mar 10 | Walt Disney Studios Motion Pictures | false |
| 21 | The Hills Have Eyes | - | - | - | $76,788 | 2,621 | $41,778,863 | Mar 10 | Fox Searchlight Pictures | false |
| 22 | Brick | - | - | - | $66,000 | 45 | $2,075,743 | Mar 31 | Focus Features | true |
| 23 | Preaching to the Choir | - | - | - | $56,000 | 143 | $405,191 | Apr 14 | Freestyle Releasing | true |
| 24 | The Pink Panther | - | - | - | $51,513 | 3,477 | $82,226,474 | Feb 10 | Sony Pictures Releasing | false |
| 25 | Basic Instinct 2 | - | - | - | $50,419 | 1,453 | $5,971,336 | Mar 31 | Sony Pictures Releasing | false |
| 26 | Firewall | - | - | - | $34,054 | 2,840 | $48,751,189 | Feb 10 | Warner Bros. | false |
| 27 | Big Momma's House 2 | - | - | - | $30,384 | 3,261 | $70,165,972 | Jan 27 | Twentieth Century Fox | false |
| 28 | 16 Blocks | - | - | - | $26,781 | 2,706 | $36,895,141 | Mar 3 | Warner Bros. | false |
| 29 | Curious George | - | - | - | $24,785 | 2,609 | $58,360,760 | Feb 10 | Universal Pictures | false |
| 30 | Date Movie | - | - | - | $24,525 | 2,898 | $48,548,426 | Feb 17 | Twentieth Century Fox | false |
| 31 | Hoodwinked! | - | - | - | $23,846 | 3,020 | $51,386,611 | Dec 16 | The Weinstein Company | false |
| 32 | Nanny McPhee | - | - | - | $21,340 | 2,148 | $47,144,110 | Jan 27 | Universal Pictures | false |
| 33 | Mrs. Henderson Presents | - | - | - | $14,418 | 522 | $11,036,366 | Dec 9 | The Weinstein Company | false |
| 34 | Hard Candy | - | - | - | $14,275 | 152 | $1,024,640 | Apr 14 | Lionsgate | false |
| 35 | Aquamarine | - | - | - | $13,189 | 2,538 | $18,597,342 | Mar 3 | Twentieth Century Fox | false |
| 36 | Neil Young: Heart of Gold | - | - | - | $12,987 | 65 | $1,904,606 | Feb 10 | Paramount Classics | false |
| 37 | Madea's Family Reunion | - | - | - | $9,882 | 2,194 | $63,257,940 | Feb 24 | Lionsgate | false |
| 38 | Transamerica | - | - | - | $9,760 | 656 | $9,015,303 | Dec 2 | The Weinstein Company | false |
| 39 | Cheaper by the Dozen 2 | - | - | - | $6,676 | 3,211 | $82,571,173 | Dec 21 | Twentieth Century Fox | false |
| 40 | Syriana | - | - | - | $5,758 | 1,775 | $50,824,620 | Nov 23 | Warner Bros. | false |
| 41 | Ask the Dust | - | - | - | $3,984 | 111 | $743,847 | Mar 10 | Paramount Classics | false |
| 42 | Walk the Line | - | - | - | $3,574 | 3,160 | $119,519,402 | Nov 18 | Twentieth Century Fox | false |
| 43 | The Libertine | - | - | - | $2,546 | 819 | $4,835,065 | Nov 25 | The Weinstein Company | false |
| 44 | Duck Season 2005 Re-release | - | - | - | $1,653 | 24 | $147,551 | Mar 10 | Warner Independent Pictures (WIP) | false |
| 45 | Night Watch 2005 Re-release | - | - | - | $1,349 | 158 | $1,502,188 | Feb 17 | Fox Searchlight Pictures | false |
