| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Blades of Glory | - | - | - | $4,889,495 | 3,467 | $118,594,548 | Mar 30 | DreamWorks | false |
| 2 | Are We Done Yet? | - | - | - | $3,509,409 | 2,944 | $49,662,533 | Apr 4 | Revolution Studios | false |
| 3 | Meet the Robinsons | - | - | - | $3,475,245 | 3,435 | $97,822,171 | Mar 30 | Walt Disney Studios Motion Pictures | false |
| 4 | Grindhouse | - | - | - | $2,516,920 | 2,629 | $25,037,897 | Apr 6 | Dimension Films | false |
| 5 | The Reaping | - | - | - | $2,498,746 | 2,603 | $25,126,214 | Apr 5 | Warner Bros. | false |
| 6 | 300 | - | - | - | $2,101,498 | 3,280 | $210,614,939 | Mar 9 | Warner Bros. | false |
| 7 | Shooter | - | - | - | $1,562,990 | 2,806 | $47,003,582 | Mar 23 | Paramount Pictures | false |
| 8 | Wild Hogs | - | - | - | $1,483,997 | 3,401 | $168,273,550 | Mar 2 | Walt Disney Studios Motion Pictures | false |
| 9 | TMNT | - | - | - | $1,059,365 | 3,120 | $54,149,098 | Mar 23 | Warner Bros. | false |
| 10 | Firehouse Dog | - | - | - | $803,085 | 2,881 | $13,932,383 | Apr 4 | Twentieth Century Fox | false |
| 11 | Premonition | - | - | - | $708,862 | 2,831 | $47,852,604 | Mar 16 | Sony Pictures Releasing | false |
| 12 | Reign Over Me | - | - | - | $597,745 | 1,747 | $19,661,987 | Mar 23 | Sony Pictures Releasing | false |
| 13 | The Hills Have Eyes 2 | - | - | - | $444,166 | 2,465 | $20,804,166 | Mar 23 | Fox Atomic | false |
| 14 | The Namesake | - | - | - | $433,868 | 335 | $13,569,248 | Mar 9 | Fox Searchlight Pictures | false |
| 15 | The Last Mimzy | - | - | - | $399,000 | 3,017 | $21,471,047 | Mar 23 | New Line Cinema | true |
| 16 | The Hoax | - | - | - | $359,000 | 1,069 | $7,164,995 | Apr 6 | Miramax | true |
| 17 | The Lookout | - | - | - | $269,000 | 955 | $4,600,585 | Mar 30 | Miramax | true |
| 18 | The Lives of Others | - | - | - | $159,000 | 259 | $11,286,112 | Feb 9 | Sony Pictures Classics | true |
| 19 | Amazing Grace | - | - | - | $147,000 | 1,162 | $21,250,683 | Feb 23 | IDP Distribution | true |
| 20 | Dead Silence | - | - | - | $117,025 | 1,806 | $16,809,076 | Mar 16 | Universal Pictures | false |
| 21 | Pride | - | - | - | $110,383 | 1,518 | $7,057,600 | Mar 23 | Lionsgate | false |
| 22 | Night at the Museum | - | - | - | $107,010 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 23 | Ghost Rider | - | - | - | $102,487 | 3,620 | $115,802,596 | Feb 16 | Sony Pictures Releasing | false |
| 24 | I Think I Love My Wife | - | - | - | $66,865 | 1,794 | $12,550,605 | Mar 16 | Fox Searchlight Pictures | false |
| 25 | Deep Sea | - | - | - | $47,906 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 26 | The Host | - | - | - | $44,000 | 116 | $2,201,923 | Mar 9 | Magnolia Pictures | true |
| 27 | Zodiac | - | - | - | $43,829 | 2,379 | $33,080,084 | Mar 2 | Paramount Pictures | false |
| 28 | Pan's Labyrinth | - | - | - | $34,625 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 29 | Miss Potter | - | - | - | $31,894 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 30 | Journey from the Fall | - | - | - | $29,733 | 14 | $641,039 | Mar 23 | ImaginAsian Pictures | false |
| 31 | Dreamgirls | - | - | - | $28,256 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 32 | Norbit | - | - | - | $24,891 | 3,145 | $95,673,607 | Feb 9 | DreamWorks | false |
| 33 | Happy Feet | - | - | - | $21,182 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 34 | The Astronaut Farmer | - | - | - | $21,096 | 2,155 | $11,003,643 | Feb 23 | Warner Bros. | false |
| 35 | Breach | - | - | - | $20,350 | 1,505 | $33,231,264 | Feb 16 | Universal Pictures | false |
| 36 | Music and Lyrics | - | - | - | $20,091 | 2,955 | $50,572,589 | Feb 14 | Warner Bros. | false |
| 37 | The Last King of Scotland | - | - | - | $16,037 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 38 | First Snow | - | - | - | $15,695 | 33 | $214,864 | Mar 23 | Yari Film Group Releasing | false |
| 39 | Letters from Iwo Jima | - | - | - | $8,325 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 40 | Arthur and the Invisibles | - | - | - | $6,879 | 2,248 | $15,132,763 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 41 | The Painted Veil | - | - | - | $6,428 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 42 | Notes on a Scandal | - | - | - | $5,973 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 43 | Blood Diamond | - | - | - | $4,983 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 44 | Epic Movie | - | - | - | $4,130 | 2,840 | $39,739,367 | Jan 26 | Twentieth Century Fox | false |
| 45 | Reno 911!: Miami | - | - | - | $3,219 | 2,702 | $20,342,161 | Feb 23 | Twentieth Century Fox | false |
| 46 | Black Snake Moan | - | - | - | $2,904 | 1,253 | $9,396,870 | Mar 2 | Paramount Vantage | false |
| 47 | The Good German | - | - | - | $1,689 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 48 | Days of Glory | - | - | - | $1,613 | 29 | $320,700 | Dec 6 | The Weinstein Company | false |
| 49 | Breaking and Entering | - | - | - | $995 | 95 | $930,469 | Dec 15 | The Weinstein Company | false |
| 50 | Hannibal Rising | - | - | - | $878 | 3,003 | $27,670,986 | Feb 9 | Metro-Goldwyn-Mayer (MGM) | false |
| 51 | Nomad: The Warrior | - | - | - | $700 | 60 | $79,123 | Mar 16 | The Weinstein Company | false |
| 52 | Eragon | - | - | - | $315 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
