| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Clash of the Titans | - | - | - | $13,812,670 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 2 | How to Train Your Dragon | - | - | - | $6,897,178 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 3 | Why Did I Get Married Too? | - | - | - | $6,609,732 | 2,155 | $60,095,852 | Apr 2 | Lionsgate | false |
| 4 | The Last Song | - | - | - | $2,897,687 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 5 | Hot Tub Time Machine | - | - | - | $2,124,205 | 2,771 | $50,287,556 | Mar 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 6 | Alice in Wonderland | - | - | - | $2,055,114 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 7 | The Bounty Hunter | - | - | - | $1,397,343 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 8 | Diary of a Wimpy Kid | - | - | - | $1,042,488 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 9 | She's Out of My League | - | - | - | $390,840 | 2,958 | $32,010,860 | Mar 12 | Paramount Pictures | false |
| 10 | Shutter Island | - | - | - | $371,027 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 11 | Green Zone | - | - | - | $335,340 | 3,004 | $35,053,660 | Mar 12 | Universal Pictures | false |
| 12 | The Ghost Writer | - | - | - | $286,583 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 13 | Avatar | - | - | - | $256,213 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 14 | Our Family Wedding | - | - | - | $225,423 | 1,609 | $20,255,281 | Mar 12 | Fox Searchlight Pictures | false |
| 15 | Greenberg | - | - | - | $184,780 | 186 | $4,234,170 | Mar 19 | Focus Features | false |
| 16 | Repo Men | - | - | - | $165,870 | 2,521 | $13,794,835 | Mar 19 | Universal Pictures | false |
| 17 | Hubble | - | - | - | $113,995 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 18 | Remember Me | - | - | - | $108,922 | 2,215 | $19,068,240 | Mar 12 | Summit Entertainment | false |
| 19 | Crazy Heart | - | - | - | $79,094 | 1,361 | $39,464,306 | Dec 16 | Fox Searchlight Pictures | false |
| 20 | The Crazies | - | - | - | $63,184 | 2,479 | $39,123,589 | Feb 26 | Overture Films | false |
| 21 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $61,629 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 22 | The Blind Side | - | - | - | $52,245 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 23 | Brooklyn's Finest | - | - | - | $52,231 | 1,939 | $27,163,593 | Mar 5 | Overture Films | false |
| 24 | Cop Out | - | - | - | $49,737 | 3,150 | $44,875,481 | Feb 26 | Warner Bros. | false |
| 25 | The Book of Eli | - | - | - | $46,114 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 26 | The Runaways | - | - | - | $44,856 | 244 | $3,573,673 | Mar 19 | Apparition | false |
| 27 | City Island | - | - | - | $37,690 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 28 | Sherlock Holmes | - | - | - | $36,240 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 29 | Tooth Fairy | - | - | - | $34,729 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 30 | Dear John | - | - | - | $33,624 | 3,062 | $80,014,842 | Feb 5 | Screen Gems | false |
| 31 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $25,499 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 32 | Valentine's Day | - | - | - | $17,378 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 33 | The Secret of Kells | - | - | - | $17,036 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 34 | Under the Sea 3D | - | - | - | $13,523 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 35 | Edge of Darkness | - | - | - | $9,897 | 3,066 | $43,313,890 | Jan 29 | Warner Bros. | false |
| 36 | A Single Man | - | - | - | $7,937 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 37 | The Young Victoria | - | - | - | $7,262 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 38 | Waking Sleeping Beauty | - | - | - | $4,465 | 5 | $80,741 | Mar 26 | Walt Disney Studios Motion Pictures | false |
| 39 | Up in the Air | - | - | - | $4,364 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 40 | Breath Made Visible: Anna Halprin | - | - | - | $3,620 | 3 | $52,387 | Apr 2 | Argot Pictures | false |
| 41 | My Name Is Khan | - | - | - | $2,588 | 125 | $4,018,771 | Feb 12 | Fox Searchlight Pictures | false |
| 42 | Don McKay | - | - | - | $2,025 | 7 | $13,722 | Apr 2 | Image Entertainment | false |
| 43 | That Evening Sun | - | - | - | $1,202 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 44 | Ca$h | - | - | - | $106 | 43 | $46,488 | Mar 26 | Roadside Attractions | false |
