| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Saw II | - | - | - | $4,526,635 | 2,949 | $87,039,965 | Oct 28 | Lionsgate | false |
| 2 | The Legend of Zorro | - | - | - | $1,223,475 | 3,520 | $46,464,023 | Oct 28 | Sony Pictures Releasing | false |
| 3 | Dreamer | - | - | - | $499,503 | 2,735 | $32,751,093 | Oct 21 | DreamWorks Distribution | false |
| 4 | Prime | - | - | - | $447,615 | 1,837 | $22,827,153 | Oct 28 | Universal Pictures | false |
| 5 | The Weather Man | - | - | - | $383,274 | 1,510 | $12,482,775 | Oct 28 | Paramount Pictures | false |
| 6 | Doom | - | - | - | $381,025 | 3,044 | $28,212,337 | Oct 21 | Universal Pictures | false |
| 7 | North Country | - | - | - | $348,128 | 2,555 | $18,337,722 | Oct 21 | Warner Bros. | false |
| 8 | Wallace & Gromit: The Curse of the Were-Rabbit | - | - | - | $334,875 | 3,656 | $56,110,897 | Oct 5 | DreamWorks Distribution | false |
| 9 | The Fog | - | - | - | $267,629 | 2,972 | $29,550,869 | Oct 14 | Revolution Studios | false |
| 10 | Flightplan | - | - | - | $237,423 | 3,424 | $89,707,299 | Sep 23 | Walt Disney Studios Motion Pictures | false |
| 11 | Elizabethtown | - | - | - | $181,311 | 2,517 | $26,850,426 | Oct 14 | Paramount Pictures | false |
| 12 | Good Night, and Good Luck. | - | - | - | $171,933 | 929 | $31,558,003 | Oct 7 | Warner Independent Pictures (WIP) | false |
| 13 | In Her Shoes | - | - | - | $151,892 | 2,840 | $32,880,591 | Oct 7 | Twentieth Century Fox | false |
| 14 | Corpse Bride | - | - | - | $112,168 | 3,204 | $53,359,111 | Sep 16 | Warner Bros. | false |
| 15 | Stay | - | - | - | $57,038 | 1,684 | $3,626,883 | Oct 21 | Twentieth Century Fox | false |
| 16 | Two for the Money | - | - | - | $56,610 | 2,397 | $22,991,379 | Oct 7 | Universal Pictures | false |
| 17 | Waiting... | - | - | - | $42,260 | 1,652 | $16,124,543 | Oct 7 | Lionsgate | false |
| 18 | The Greatest Game Ever Played | - | - | - | $42,030 | 1,810 | $15,337,393 | Sep 30 | Walt Disney Studios Motion Pictures | false |
| 19 | Shopgirl | - | - | - | $35,600 | 493 | $10,284,523 | Oct 21 | Walt Disney Studios Motion Pictures | false |
| 20 | Kiss Kiss Bang Bang | - | - | - | $32,943 | 226 | $4,243,756 | Oct 21 | Warner Bros. | false |
| 21 | Serenity | - | - | - | $32,340 | 2,189 | $25,514,517 | Sep 30 | Universal Pictures | false |
| 22 | The 40-Year-Old Virgin | - | - | - | $25,895 | 3,006 | $109,449,237 | Aug 19 | Universal Pictures | false |
| 23 | March of the Penguins | - | - | - | $22,011 | 2,506 | $77,437,223 | Jun 24 | Warner Independent Pictures (WIP) | false |
| 24 | Charlie and the Chocolate Factory | - | - | - | $15,498 | 3,790 | $206,459,076 | Jul 15 | Warner Bros. | false |
| 25 | Just Like Heaven | - | - | - | $15,445 | 3,543 | $48,318,130 | Sep 16 | DreamWorks Distribution | false |
| 26 | Separate Lies | - | - | - | $13,479 | 127 | $924,260 | Sep 16 | Fox Searchlight Pictures | false |
| 27 | El vacilón: The Movie | - | - | - | $12,278 | 36 | $1,291,951 | Oct 21 | Televisa Cine | false |
| 28 | Everything Is Illuminated | - | - | - | $10,058 | 110 | $1,712,337 | Sep 16 | Warner Independent Pictures (WIP) | false |
| 29 | Four Brothers | - | - | - | $8,451 | 2,649 | $74,494,381 | Aug 12 | Paramount Pictures | false |
| 30 | Roll Bounce | - | - | - | $7,646 | 1,661 | $17,380,866 | Sep 23 | Fox Searchlight Pictures | false |
| 31 | Three... Extremes 2005 Re-release | - | - | - | $6,934 | 19 | $77,532 | Oct 28 | Lionsgate | false |
| 32 | War of the Worlds | - | - | - | $5,593 | 3,910 | $234,280,354 | Jun 29 | Paramount Pictures | false |
| 33 | Paradise Now | - | - | - | $5,034 | 65 | $1,457,843 | Oct 28 | Warner Independent Pictures (WIP) | false |
| 34 | Lord of War | - | - | - | $4,743 | 2,814 | $24,149,632 | Sep 16 | Lionsgate | false |
| 35 | Grizzly Man | - | - | - | $4,283 | 105 | $3,178,403 | Aug 12 | Lionsgate | false |
| 36 | Transporter 2 | - | - | - | $4,218 | 3,320 | $43,095,856 | Sep 2 | Twentieth Century Fox | false |
| 37 | Fantastic Four | - | - | - | $3,895 | 3,619 | $154,696,080 | Jul 8 | Twentieth Century Fox | false |
| 38 | Mr. & Mrs. Smith | - | - | - | $3,388 | 3,451 | $186,336,279 | Jun 10 | Twentieth Century Fox | false |
| 39 | The Prize Winner of Defiance, Ohio | - | - | - | $2,331 | 41 | $627,844 | Sep 30 | DreamWorks Distribution | false |
| 40 | Little Manhattan | - | - | - | $1,407 | 35 | $385,373 | Sep 30 | Twentieth Century Fox | false |
| 41 | Mad Hot Ballroom | - | - | - | $733 | 202 | $8,117,961 | May 13 | Paramount Classics | false |
| 42 | Hustle & Flow | - | - | - | $225 | 1,016 | $22,202,809 | Jul 22 | Paramount Classics | false |
| 43 | Duma | - | - | - | $170 | 42 | $870,067 | Apr 22 | Warner Bros. | false |
| 44 | Cinderella Man | - | - | - | $66 | 2,820 | $61,649,911 | Jun 3 | Universal Pictures | false |
| 45 | Asylum | - | - | - | $40 | 55 | $375,403 | Aug 12 | Paramount Classics | false |
