| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $9,484,970 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 2 | The Pursuit of Happyness | - | - | - | $4,952,800 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 3 | Dreamgirls | - | - | - | $3,528,651 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 4 | The Good Shepherd | - | - | - | $3,048,995 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 5 | Charlotte's Web | - | - | - | $2,803,709 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 6 | Rocky Balboa | - | - | - | $2,437,806 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 7 | We Are Marshall | - | - | - | $2,157,759 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 8 | Eragon | - | - | - | $2,013,004 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 9 | Happy Feet | - | - | - | $1,968,736 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 10 | The Holiday | - | - | - | $1,689,123 | 2,698 | $63,224,849 | Dec 8 | Sony Pictures Releasing | false |
| 11 | Casino Royale | - | - | - | $1,314,772 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 12 | Blood Diamond | - | - | - | $1,268,384 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 13 | Apocalypto | - | - | - | $691,656 | 2,465 | $50,866,635 | Dec 8 | Walt Disney Studios Motion Pictures | false |
| 14 | Black Christmas | - | - | - | $588,188 | 1,544 | $16,273,581 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 15 | The Nativity Story | - | - | - | $417,000 | 3,083 | $37,629,831 | Dec 1 | New Line Cinema | true |
| 16 | The Queen | - | - | - | $283,000 | 1,850 | $56,441,711 | Sep 30 | Miramax | true |
| 17 | Unaccompanied Minors | - | - | - | $241,267 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 18 | Deja Vu | - | - | - | $161,244 | 3,108 | $64,038,616 | Nov 22 | Walt Disney Studios Motion Pictures | false |
| 19 | Pan's Labyrinth | - | - | - | $134,994 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 20 | Children of Men | - | - | - | $125,477 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 21 | Borat | - | - | - | $122,721 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 22 | The Santa Clause 3: The Escape Clause | - | - | - | $120,702 | 3,458 | $84,500,122 | Nov 3 | Walt Disney Studios Motion Pictures | false |
| 23 | Babel | - | - | - | $118,018 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 24 | Notes on a Scandal | - | - | - | $116,374 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 25 | The Painted Veil | - | - | - | $109,850 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 26 | The History Boys | - | - | - | $103,473 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 27 | The Departed | - | - | - | $87,356 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 28 | Deck the Halls | - | - | - | $69,612 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 29 | The Polar Express 2006 IMAX Release | - | - | - | $36,008 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 30 | The Good German | - | - | - | $32,201 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 31 | Deep Sea | - | - | - | $26,630 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 32 | Letters from Iwo Jima | - | - | - | $25,225 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 33 | For Your Consideration | - | - | - | $11,914 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 34 | Little Miss Sunshine | - | - | - | $10,386 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 35 | Bobby | - | - | - | $9,326 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 36 | Flicka | - | - | - | $8,752 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 37 | Perfume: The Story of a Murderer | - | - | - | $8,310 | 280 | $2,223,293 | Dec 27 | DreamWorks | false |
| 38 | The Last King of Scotland | - | - | - | $5,814 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 39 | The Illusionist | - | - | - | $5,743 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 40 | The Wedding Weekend | - | - | - | $4,631 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 41 | The Marine | - | - | - | $3,672 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 42 | The Fountain | - | - | - | $3,085 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 43 | Miss Potter | - | - | - | $3,079 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 44 | A Good Year | - | - | - | $3,016 | 2,067 | $7,459,300 | Nov 10 | Twentieth Century Fox | false |
| 45 | Turistas | - | - | - | $2,739 | 1,572 | $7,027,762 | Dec 1 | Fox Atomic | false |
| 46 | Copying Beethoven | - | - | - | $2,544 | 29 | $384,029 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 47 | Fast Food Nation | - | - | - | $1,033 | 321 | $1,005,539 | Nov 17 | Fox Searchlight Pictures | false |
| 48 | Van Wilder: The Rise of Taj | - | - | - | $601 | 1,979 | $4,300,645 | Dec 1 | Metro-Goldwyn-Mayer (MGM) | false |
