| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Twilight Saga: Eclipse | - | - | - | $83,637,242 | 4,468 | $300,531,751 | Jun 30 | Summit Entertainment | false |
| 2 | The Last Airbender | - | - | - | $51,804,232 | 3,203 | $131,772,187 | Jul 1 | Paramount Pictures | false |
| 3 | Toy Story 3 | - | - | - | $43,057,129 | 4,028 | $415,004,880 | Jun 18 | Walt Disney Studios Motion Pictures | false |
| 4 | Grown Ups | - | - | - | $26,052,792 | 3,534 | $162,001,186 | Jun 25 | Sony Pictures Releasing | false |
| 5 | Knight and Day 2010 Re-release | - | - | - | $14,151,734 | 3,104 | $76,423,035 | Jun 23 | Twentieth Century Fox | false |
| 6 | The Karate Kid | - | - | - | $11,031,522 | 3,740 | $176,591,618 | Jun 11 | Sony Pictures Releasing | false |
| 7 | The A-Team | - | - | - | $4,403,057 | 3,544 | $77,222,099 | Jun 11 | Twentieth Century Fox | false |
| 8 | Get Him to the Greek | - | - | - | $1,723,840 | 2,702 | $60,974,475 | Jun 4 | Universal Pictures | false |
| 9 | Shrek Forever After | - | - | - | $1,275,957 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 10 | Cyrus | - | - | - | $1,094,111 | 454 | $7,468,936 | Jun 18 | Fox Searchlight Pictures | false |
| 11 | Letters to Juliet | - | - | - | $972,374 | 2,975 | $53,032,453 | May 14 | Summit Entertainment | false |
| 12 | Prince of Persia: The Sands of Time | - | - | - | $884,816 | 3,646 | $90,759,676 | May 28 | Walt Disney Studios Motion Pictures | false |
| 13 | Iron Man 2 | - | - | - | $875,834 | 4,390 | $312,433,331 | May 7 | Paramount Pictures | false |
| 14 | I Am Love | - | - | - | $722,544 | 166 | $5,005,465 | Jun 18 | Magnolia Pictures | false |
| 15 | Solitary Man | - | - | - | $657,233 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 16 | Killers | - | - | - | $628,261 | 2,859 | $47,059,963 | Jun 4 | Lionsgate | false |
| 17 | Winter's Bone | - | - | - | $599,597 | 141 | $6,531,503 | Jun 11 | Roadside Attractions | false |
| 18 | Sex and the City 2 | - | - | - | $528,330 | 3,445 | $95,347,692 | May 27 | Warner Bros. | false |
| 19 | Marmaduke | - | - | - | $483,697 | 3,213 | $33,644,788 | Jun 4 | Twentieth Century Fox | false |
| 20 | How to Train Your Dragon | - | - | - | $481,505 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 21 | Joan Rivers: A Piece of Work | - | - | - | $455,440 | 115 | $2,930,687 | Jun 11 | IFC Films | false |
| 22 | Robin Hood | - | - | - | $449,745 | 3,505 | $105,269,730 | May 14 | Universal Pictures | false |
| 23 | I Hate Luv Storys | - | - | - | $448,502 | 85 | $847,993 | Jun 30 | UTV Motion Pictures | false |
| 24 | Hubble | - | - | - | $345,523 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 25 | The Girl with the Dragon Tattoo | - | - | - | $269,706 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 26 | Date Night | - | - | - | $250,435 | 3,380 | $98,711,404 | Apr 9 | Twentieth Century Fox | false |
| 27 | The Secret in Their Eyes | - | - | - | $240,617 | 166 | $6,391,436 | Apr 16 | Sony Pictures Classics | false |
| 28 | Please Give | - | - | - | $233,476 | 272 | $4,033,574 | Apr 30 | Sony Pictures Classics | false |
| 29 | Splice 2010 Re-release | - | - | - | $200,491 | 2,450 | $17,010,170 | Jun 4 | Warner Bros. | false |
| 30 | Coco Chanel & Igor Stravinsky | - | - | - | $177,208 | 74 | $1,621,226 | Jun 11 | Sony Pictures Classics | false |
| 31 | Jonah Hex | - | - | - | $164,259 | 2,825 | $10,547,117 | Jun 18 | Warner Bros. | false |
| 32 | Clash of the Titans | - | - | - | $154,391 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 33 | City Island | - | - | - | $149,420 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 34 | Death at a Funeral | - | - | - | $144,894 | 2,459 | $42,739,347 | Apr 16 | Screen Gems | false |
| 35 | Furry Vengeance | - | - | - | $118,989 | 3,002 | $17,630,465 | Apr 30 | Summit Entertainment | false |
| 36 | Micmacs | - | - | - | $84,464 | 52 | $1,262,079 | May 28 | Sony Pictures Classics | false |
| 37 | Exit Through the Gift Shop | - | - | - | $82,393 | 46 | $3,291,250 | Apr 16 | Producers Distribution Agency (PDA) | false |
| 38 | Mother and Child | - | - | - | $82,270 | 119 | $1,110,509 | May 7 | Sony Pictures Classics | false |
| 39 | Restrepo | - | - | - | $82,088 | 52 | $1,330,894 | Jun 25 | National Geographic Entertainment | false |
| 40 | Harry Brown | - | - | - | $74,635 | 67 | $1,818,681 | Apr 30 | The Samuel Goldwyn Company | false |
| 41 | Just Wright | - | - | - | $72,963 | 1,831 | $21,540,363 | May 14 | Fox Searchlight Pictures | false |
| 42 | The Back-up Plan | - | - | - | $68,902 | 3,280 | $37,490,007 | Apr 23 | CBS Films | false |
| 43 | Ondine | - | - | - | $68,688 | 39 | $550,472 | Jun 4 | Magnolia Pictures | false |
| 44 | The Bounty Hunter | - | - | - | $67,129 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 45 | Under the Sea 3D | - | - | - | $63,302 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 46 | Love Ranch | - | - | - | $60,353 | 11 | $137,885 | Jun 30 | Entertainment One | false |
| 47 | The Killer Inside Me | - | - | - | $60,251 | 17 | $217,277 | Jun 18 | IFC Films | false |
| 48 | Oceans | - | - | - | $58,708 | 1,232 | $19,422,319 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 49 | Diary of a Wimpy Kid | - | - | - | $56,434 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 50 | A Nightmare on Elm Street | - | - | - | $53,403 | 3,332 | $63,075,011 | Apr 30 | Warner Bros. | false |
| 51 | Magnificent Desolation: Walking on the Moon | - | - | - | $52,078 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 52 | Babies | - | - | - | $50,193 | 543 | $7,320,323 | May 7 | Focus Features | false |
| 53 | South of the Border | - | - | - | $45,951 | 12 | $198,600 | Jun 25 | Cinema Libre Studio | false |
| 54 | The Last Song | - | - | - | $45,700 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 55 | Wild Grass | - | - | - | $39,736 | 23 | $403,952 | Jun 25 | Sony Pictures Classics | false |
| 56 | Avatar | - | - | - | $35,706 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 57 | The City of Your Final Destination | - | - | - | $22,628 | 26 | $493,296 | Apr 16 | Screen Media Films | false |
| 58 | Let it Rain | - | - | - | $16,796 | 6 | $111,844 | Jun 18 | IFC Films | false |
| 59 | Holy Rollers | - | - | - | $15,416 | 20 | $303,064 | May 21 | First Independent Pictures | false |
| 60 | Raavan | - | - | - | $15,262 | 120 | $708,726 | Jun 18 | Reliance Big Pictures | false |
| 61 | Deep Sea | - | - | - | $13,729 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 62 | The Secret of Kells | - | - | - | $13,248 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 63 | Raajneeti | - | - | - | $11,003 | 124 | $1,514,558 | Jun 4 | UTV Motion Pictures | false |
| 64 | Mid-August Lunch | - | - | - | $9,050 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 65 | Agora | - | - | - | $8,160 | 17 | $619,423 | May 28 | Newmarket Films | false |
| 66 | La Mission | - | - | - | $7,767 | 47 | $1,062,941 | Apr 9 | Screen Media Films | false |
| 67 | The Square 2010 Re-release | - | - | - | $7,379 | 24 | $406,116 | Apr 9 | Apparition | false |
| 68 | Princess Kaiulani | - | - | - | $7,379 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 69 | The Nature of Existence | - | - | - | $7,265 | 4 | $54,645 | Jun 18 | Walking Shadows | false |
| 70 | Alice in Wonderland | - | - | - | $6,640 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 71 | Stonewall Uprising | - | - | - | $6,075 | 10 | $128,203 | Jun 16 | First Run | false |
| 72 | Breathless 2010 Re-release | - | - | - | $5,875 | 12 | $363,031 | May 28 | Rialto Pictures | false |
| 73 | Only the Brave | - | - | - | $5,787 | 5 | $150,000 | May 28 | Indican Pictures | false |
| 74 | Sea Monsters: A Prehistoric Adventure | - | - | - | $4,350 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 75 | Best Worst Movie | - | - | - | $4,350 | 2 | $109,895 | Apr 23 | Abramorama | false |
| 76 | Everyone Else | - | - | - | $4,204 | 5 | $102,042 | Apr 9 | The Cinema Guild | false |
| 77 | The Lottery | - | - | - | $4,098 | 3 | $54,543 | Jun 11 | Variance Films | false |
| 78 | The Sun Behind the Clouds: Tibet's Struggle for Freedom | - | - | - | $3,907 | 4 | $67,095 | Mar 31 | Balcony Releasing | false |
| 79 | Rosencrantz and Guildenstern Are Undead | - | - | - | $3,608 | 4 | $71,007 | Jun 4 | Indican Pictures | false |
| 80 | The Joneses | - | - | - | $3,581 | 217 | $1,475,746 | Apr 16 | Roadside Attractions | false |
| 81 | OSS 117: Lost in Rio | - | - | - | $3,260 | 7 | $89,375 | May 7 | Music Box Films | false |
| 82 | Kings of the Evening | - | - | - | $3,242 | 5 | $99,270 | Jun 11 | Indican Pictures | false |
| 83 | Only When I Dance | - | - | - | $2,923 | 1 | $8,738 | Jul 2 | Film Movement | false |
| 84 | Sweetgrass | - | - | - | $2,658 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 85 | Racing Dreams | - | - | - | $2,494 | 33 | $65,082 | May 21 | Hannover House | false |
| 86 | Survival of the Dead | - | - | - | $2,444 | 20 | $101,740 | May 28 | Magnolia Pictures | false |
| 87 | Casino Jack and the United States of Money | - | - | - | $2,287 | 21 | $176,865 | May 7 | Magnolia Pictures | false |
| 88 | Cropsey | - | - | - | $1,619 | 4 | $52,476 | Jun 4 | Cinema Purgatorio | false |
| 89 | John Rabe | - | - | - | $1,376 | 6 | $67,519 | May 21 | Strand Releasing | false |
| 90 | Chloe | - | - | - | $1,245 | 350 | $3,075,255 | Mar 26 | Sony Pictures Classics | false |
| 91 | A Town Called Panic | - | - | - | $958 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 92 | Small Change | - | - | - | $568 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 93 | Behind the Burly Q | - | - | - | $541 | 2 | $23,889 | Apr 23 | First Run | false |
| 94 | Space Station 3D | - | - | - | $484 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 95 | U2 3D | - | - | - | $346 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 96 | Breath Made Visible: Anna Halprin | - | - | - | $155 | 3 | $52,387 | Apr 2 | Argot Pictures | false |
